Results 61 to 70 of about 72,402 (211)

Identifying and testing for hereditary susceptibility to breast/ovarian cancer in Serbia: Where are we now? [PDF]

Archive of Oncology, 2006
About 90% of all breast cancers can be considered as sporadic, without inherited gene alteration. The rest of breast cancers (about 5 to 10%) are considered hereditary, most commonly caused by alterations of BRCA1/2 tumor suppressor genes. Lifetime risks
Branković-Magić Mirjana, Dobričić Jelena, Janković Radmila, Konstantopoulou Irene, Yannoukakos Drakoulis, Radulović Siniša   +5 more
doaj   +1 more source

Expression of BRCA1 and BRCA2 Genes in Patients Undergoing Transrectal Prostate Biopsy

Revista Brasileira de Cancerologia
Introduction: Prostate cancer (PCa) is the second most common type of cancer among the male population. Men carrying mutations in the BRCA1 and BRCA2 genes are known to have a greater risk of developing PCa.
Eduardo Maciel Narvaes, Alyna Araújo e Marcondes, Roberto de Andrade Garcia Filho, Paulo Gabriel da Silva Mota, Patricia de Lima Lemos, Claudinéia de Araújo   +5 more
doaj   +1 more source

Identification of genes induced by BRCA1 in breast cancer cells [PDF]

, 2002
Cataloged from PDF version of article.Inherited mutations of the BRCA1 gene predispose to cancer of the breast, ovaries and other organs. The BRCA1 protein product is implicated in the maintenance of chromosomal integrity as BRCA1-deficient cells ...
Atalay, Arzu
core   +2 more sources

Prevalence of specific and recurrent/founder pathogenic variants in BRCA genes in breast and ovarian cancer in North Africa

BMC Cancer, 2022
Background Elucidation of specific and recurrent/founder pathogenic variants (PVs) in BRCA (BRCA1 and BRCA2) genes can make the genetic testing, for breast cancer (BC) and/or ovarian cancer (OC), affordable for developing nations.
Oubaida ElBiad, Abdelilah Laraqui, Fatima El Boukhrissi, Chaimaa Mounjid, Maryame Lamsisi, Tahar Bajjou, Hicham Elannaz, Amine Idriss Lahlou, Jaouad Kouach, Khadija Benchekroune, Mohammed Oukabli, Hafsa Chahdi, Moulay Mustapha Ennaji, Rachid Tanz, Yassir Sbitti, Mohammed Ichou, Khalid Ennibi, Bouabid Badaoui, Yassine Sekhsokh   +18 more
doaj   +1 more source

Brca1 in immunoglobulin gene conversion and somatic hypermutation [PDF]

DNA Repair, 2008
Defects in Brca1 confer susceptibility to breast cancer and genomic instability indicative of aberrant repair of DNA breaks. Brca1 was previously implicated in the homologous recombination pathway via effects on the assembly of recombinase Rad51. Activation-induced cytidine deaminase (AID) deaminates C to U in B lymphocyte immunoglobulin (Ig) DNA to ...
Simonne, Longerich, Brian J, Orelli, Richard W, Martin, Douglas K, Bishop, Ursula, Storb   +4 more
openaire   +2 more sources

Use of Gene Expression Profiles of Peripheral Blood Lymphocytes to Distinguish BRCA1 Mutation Carriers in High Risk Breast Cancer Families

Cancer Informatics, 2009
Mutations in two major genes, BRCA1 and BRCA2, account for up to 30% of families with hereditary breast cancer. Unfortunately, in most families there is little to indicate which gene should be targeted first for mutation screening, which is labor ...
Marie-Laure Vuillaume, Nancy Uhrhammer, Véronique Vidal, Valérie Sylvain Vidal, Valérie Chabaud, Beline Jesson, Fabrice Kwiatkowski, Yves-Jean Bignon   +7 more
doaj  

Kaiso mediates transcription and RNA splicing in colorectal carcinoma: role of BRCA1 in the Kaiso enhanceosome

Open Biology
Kaiso (ZBTB33) is a transcription factor involved in mitotic clonal expansion and tumorigenesis in association with Adenomatous Polyposis Coli (APC) loss of heterozygosity. ENCODE data show strong overlap of the Kaiso promoter-binding site—encode-derived
Weifeng Luo, Manish K. Tripathi, Qi Liu, Lei Chen, Robert W. Cowan, Juliet M. Daniel, Chi Yan, Ann Richmond, Albert B. Reynolds   +8 more
doaj   +1 more source

Genetic epidemiology of breast cancer in CYPRUS: A case -control study of DNA repair genes [PDF]

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The occurrence of early-onset breast cancer (EOBC) has been associated with germline mutations in the BRCA1 and BRCA2 genes.
Loizidou, Maria, Liozidou, Maria
core  

Carcinogenic potential of ovulation stimulation in BRCA1/2 gene mutation carriers in assisted reproductive technology programs

Russian Open Medical Journal, 2022
Mutations of the BRCA1/2 genes constitute a fundamental and independent risk factor in the genesis of both breast cancer and ovarian cancer. The specifics of the infertility treatment effect on the risk of developing cancer in carriers of mutations in ...
Lidia A. Klyukina, Elena A. Sosnova, Anton A. Ishchenko   +2 more
doaj   +1 more source

Identification of a Preneoplastic Gene Expression Profile in Tubal Epithelium of BRCA1 Mutation Carriers

Neoplasia: An International Journal for Oncology Research, 2010
Microinvasive carcinomas and high-grade intraepithelial neoplasms are commonly discovered within the fallopian tube of BRCA1 mutation carriers at the time of risk-reducing salpingo-oophorectomy, suggesting that many BRCA1-mutated ovarian carcinomas ...
Joshua Z. Press, Kaitlyn Wurz, Barbara M. Norquist, Ming K. Lee, Christopher Pennil, Rochelle Garcia, Piri Welcsh, Barbara A. Goff, Elizabeth M. Swisher   +8 more
doaj   +1 more source