Results 81 to 90 of about 72,402 (211)
Journal of Experimental & Clinical Cancer Research, 2010 Background Breast cancer is one of the most common diseases affecting women. Inherited susceptibility genes, BRCA1 and BRCA2, are considered in breast, ovarian and other common cancers etiology.
Hashishe Mervat M +2 more
doaj +1 more source
The impact of known breast cancer polygenes on critical illness insurance
, 2015 Genetic studies indicate that the inherited risk of breast cancer is mediated by the well-studied major genes BRCA1 and BRCA2, and a polygenic component, probably with many genes each making a small contribution. Recently, seven polygenes have been found
Macdonald, Angus Smith; id_orcid +2 more
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Low Frequency of 185delAG Founder Mutation of BRCA1 Gene in Iranian Breast Cancer Patients [PDF]
AIM: The mutations in two breast cancer susceptibility genes, BRCA1 and BRCA2, are frequently associated with familial breast cancer. In this study, we aimed to investigate the probable founder mutations of BRCA1 and BRCA2 genes in Iranian breast ...
حسینی اصل, سید سعید +5 more
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Testing for the breast cancer predisposition gene, BRCA1 [PDF]
BMJ, 1996 Each year there are 27 768 cases of breast cancer and 5100 cases of ovarian cancer in Britain.1 Most of these cases will be sporadic, in which genetic changes occur only within cancer cells. However, in rare instances a genetic change will have been inherited.
openaire +2 more sources
Preventing hereditary cancers caused by opportunistic carcinogens
, 2011 Objectives Previous studies reported inherited BRCA1/2 deficits appear to cause cancer by impairing normal protective responses to some carcinogens.
Bernard Friedenson
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Breast Cancer Susceptibility Genes: BRCA1 and BRCA2
Medicine, 1998 Mutations in the BRCA1 and BRCA2 genes lead to an increased susceptibility to breast, ovarian, and other cancers. It is estimated that 3%-8% of all women with breast cancer will be found to carry a mutation in 1 of these genes. Families with multiple affected first-degree relatives and patients with early-onset disease have been found to harbor ...
L C, Brody, B B, Biesecker
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The influence of genetic variation in thirty selected genes on the clinical characteristics of early onset breast cancer [PDF]
, 2008 Introduction: common variants that alter breast cancer risk are being discovered. Here, we determine how these variants influence breast cancer prognosis, risk and tumour characteristics.Methods: we selected 1,001 women with early onset nonfamilial ...
Victoria Hammond +15 more
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Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in Cypriot population.
, 2010 Inability to correctly repair DNA damage is known to play a role in the development of breast cancer. Single nucleotide polymorphisms (SNPs) of DNA repair genes have been identified, which modify the DNA repair capacity, which in turn may affect the risk
Daniel, M +9 more
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Relationship between DNA damage response and telomere maintenance [PDF]
, 2012 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Telomeres are regions of repetitive DNA bound with a set of specialized proteins required to protect chromosomes from fusing with each other and from ...
Ojani, Maryam
core
Breast cancer genes: beyond BRCA1 and BRCA2
Frontiers in Bioscience, 2013 Breast cancer (BC) is a heterogeneous disease. The majority of breast cancer cases (about 70 percent) are considered sporadic. Familial breast cancer (about 30 percent of patients), often seen in families with a high incidence of BC, has been associated with a number of high-, moderate-, and low-penetrance susceptibility genes.
Sandra E, Filippini, Ana, Vega
openaire +3 more sources