Results 101 to 110 of about 72,402 (211)

Using a brain-like endothelial cell differentiation to characterize the CS79iBRCA-n2 BRCA1 mutated patient derived stem cell line

Frontiers in Cell and Developmental Biology
BRCA1/2 genes are considered tumor suppressor genes and help repair damaged DNA. Pathogenic germline mutations of BRCA1/2 genes are the most common hereditary cause of breast cancer and ovarian cancer.
Natalie G. Alexander, Kylie A. Buchanan, Alexandra E. Meyer, Lauren M. Mitterway, Caroline O. Vanderburgh, Shreyas S. Rao, Shreyas S. Rao, Shreyas S. Rao, Brandon J. Kim, Brandon J. Kim, Brandon J. Kim, Brandon J. Kim, Brandon J. Kim   +12 more
doaj   +1 more source

Rapid screening by Surveyor Nuclease-based mutation detection for BRCA1 and BRCA2 genes

, 2009
Twenty-three percent of first diagnosed breast cancer patients resulted to be candidate for BRCA genetic test and, among these, BRCA1 and BRCA2 mutations occur in almost 20% patients. BRCA testing is complicated by the large gene region and the extent of
B. Pilato, M. Martinucci, SALVATORE, FRANCESCO, P. Zaccagna, M. Iorio, S. Papadimitriou, A. Paradiso, S. Tommasi, FRISSO, GIULIA   +8 more
core  

Genomic alterations in histopathologically normal breast tissue from BRCA1 mutation carriers may be caused by BRCA1 haploinsufficiency

, 2010
Multiple biopsies of normal breast tissue from 10 BRCA1 mutation carriers have been analyzed using array-based comparative genomic hybridization. Normal breast tissue from five age-matched control subjects without a family history of breast cancer was ...
Rennstam, Karin,, Ringberg, Anita,, Cunliffe, Heather E, Olsson, Håkan,, Hedenfalk, Ingrid,, Landberg, Göran,, Lund University.   +6 more
core   +1 more source

The Molecular Detection of Germline Mutations in the BRCA1 and BRCA2 Genes Associated with Breast and Ovarian Cancer in a Romanian Cohort of 616 Patients

Current Issues in Molecular Biology
The objective of this study was to identify and classify the spectrum of mutations found in the BRCA1 and BRCA2 genes associated with breast and ovarian cancer in female patients in Romania.
Liliana-Georgiana Grigore, Viorica-Elena Radoi, Alexandra Serban, Adina Daniela Mihai, Ileana Stoica   +4 more
doaj   +1 more source

BRCA1 Gene [PDF]

, 2020
openaire   +1 more source

SYK expression level distinguishes control from BRCA1-mutated lymphocytes

, 2018
Tamar Zahavi,1,2,* Amir Sonnenblick,1,3,* Yael Shimshon,2 Luna Kadouri,1 Tamar Peretz,1 Asher Y Salmon,1,* Mali Salmon-Divon,2,* 1Sharett Institute of Oncology, Hadassah Hebrew University Medical Center, Jerusalem, Israel; 2Genomic Bioinformatics ...
Peretz T, Salmon-Divon M, Sonnenblick A, Kadouri L, Zahavi T, Salmon AY, Shimshon Y   +6 more
core  

Genome-wide linkage scan for breast cancer susceptibility loci in Swedish hereditary non-BRCA1/2 families: suggestive linkage to 10q23.32-q25.3.

, 2006
The two breast cancer genes BRCA1 and BRCA2 were identified more than 10 years ago and, depending on population, mutations in these genes are responsible for a varying percentage of familial breast cancer.
Karin Björck, Jan Wahlström, Nilsson, Staffan,, Nordling, Margareta, Tommy Martinsson, Wallgren, Arne, Arne Wallgren, Bergman, Annika,, Margareta Nordling, Martinsson, Tommy,, Björck, Karin,, Karlsson, Per, Per Karlsson, Berggren, Jonna,, Martinsson, Tommy, Jonna Berggren, Nilsson, Staffan, Wahlström, Jan, Wahlström, Jan,, Nordling, Margareta,, Berggren, Jonna, Annika Bergman, Wallgren, Arne,, Bj\uf6rck, Karin, Karlsson, Per,, Bergman, Annika, Staffan Nilsson, Wahlstr\uf6m, Jan, Björck, Karin   +28 more
core   +1 more source

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage

, 2019
BRCA1 is a breast and ovarian tumor suppressor. Given its numerous incompletely understood functions and the possibility that more exist, we performed complementary systematic screens in search of new BRCA1 protein-interacting partners.
Zack, Travis I., Sahni, Nidhi, Xia, Xianfang, McKinney, Kristine M., Joung, J. Keith, Reyon, Deepak, Adelmant, Guillaume, Hill, Sarah J., Marto, Jarrod A., Vidal, Marc, Beroukhim, Rameen, Rolland, Thomas, Livingston, David M., Dricot, Amélie, Jacob, Yves, Tsai, Shengdar Q., Owen, Matthew S., Gaudet, Suzanne, Hao, Tong, Hill, David E., Clark, Allison P.   +20 more
core   +1 more source

How do mutations affecting the breast cancer genes BRCA1 and BRCA2 cause cancer susceptibility? [PDF]

DNA Repair (Amst), 2019
Venkitaraman AR.
europepmc   +1 more source

BRCA1 Gene Mutation [PDF]

, 2020
openaire   +1 more source