Results 91 to 100 of about 72,402 (211)
Proportion of pathogenic mutations detected in BRCA1/2 and non-BRCA1/2 genes.
, 2019 Proportion of pathogenic mutations detected in BRCA1/2 and non-BRCA1/2 genes.
Pei Yi Ong (6470513) +2 more
core +1 more source
Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1). [PDF]
Sci Rep, 2022 Berling-Ernst A +14 more
europepmc +1 more source
Clinical characteristics of patients with Breast and / or Ovarian Cancer with mutations in the BRCA1 and BRCA2 genes in Córdoba, Argentina [PDF]
Rev Fac Cien Med Univ Nac Cordoba, 2022 Martin CA +9 more
europepmc +1 more source
Population testing for cancer predisposing BRCA1/BRCA2 mutations
, 2014 Background: Technological advances raise the possibility of systematic population-based genetic testing for cancer-predisposing mutations, but it is uncertain whether benefits outweigh disadvantages.
Wardle, J
core
PLoS ONE, 2016 DNA methylation can mimic the effects of both germline and somatic mutations for cancer predisposition genes such as BRCA1 and p16INK4a. Constitutional DNA methylation of the BRCA1 promoter has been well described and is associated with an increased risk
Cameron M Scott +8 more
doaj +1 more source
The Relationship BRCA1/2 Genes and Family History in Ovarian Cancers
, 2020 BRCA1/2 genes are responsible for the hereditary breast and ovarian cancer syndrome. In this study, Turkish women with ovarian cancer were investigated in terms of demographic, clinicopathologic and family cancer stories according to their condition of ...
Duzkale, Neslihan +3 more
core +1 more source
BRCA1/2 expression patterns in different grades of oral squamous cell carcinoma
, 2020 Background: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide and has a poor prognosis. The breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) genes are the key tumor suppressor genes responding in the cases of DNA damage ...
Rafizadeh, M, Irani, S
core +1 more source
BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors
Tumor Biology, 2017 A broad spectrum of tumors develop resistance to classic chemotherapy, necessitating the discovery of new therapies. One successful strategy exploits the synthetic lethality between poly(ADP-ribose) polymerase 1/2 proteins and DNA damage response genes ...
Hana Paculová +9 more
doaj +1 more source
A theory for the tissue specificity of BRCA1/2 related and other hereditary cancers
, 2010 Women who inherit a defective BRCA1 or BRCA2 gene have risks for breast and ovarian cancer that are so high and seem so selective that many mutation carriers choose to have prophylactic surgery. There has been much conjecture to explain such apparently
Bernard Friedenson
core
, 2019 Purpose: The main risk factor for familial breast cancer is the presence of mutations in BRCA1 and BRCA2 genes. The prevalence of mutations in these genes is heterogeneous and varies according to geographical origin of studied families.
Barreto, Guillermo +7 more
core +1 more source