Results 111 to 120 of about 72,402 (211)

BRCA1 regulation of breast cancer cell motility

Breast cancer remains a leading cause of cancer-related mortality globally, generating a need for a deeper understanding of the molecular mechanisms driving its progression. The protein product of BRCA1, a crucial tumour suppressor gene, has emerged as a
Hernandez Nuñez, Zayra
core   +1 more source

Clinical follow up of Mexican women with early onset of breast cancer and mutations in the BRCA1 and BRCA2 genes Estudio de seguimiento clínico de mujeres mexicanas con cáncer de mama de inicio temprano y mutaciones en los genes BRCA1 y BRCA2

Salud Pública de México, 2005
OBJECTIVE: This study describes the presence of mutations in BRCA1 and BRCA2 genes in a group of Mexican women and the clinical evolution of early onset breast cancer (EOBC).
Ana Laura Calderón-Garcidueñas, Pablo Ruiz-Flores, Ricardo M Cerda-Flores, Hugo A Barrera-Saldaña   +3 more
doaj  

Implication of BRCA1 gene in breast cancer.

Indian journal of experimental biology, 2001
Breast cancer susceptibility gene (BRCA1) is known to be responsible for hereditary breast and ovarian cancer. This gene is highly penetrant conferring a risk for 0.92 by the age of 70. Germline mutation in this gene leads to susceptibility to breast and ovarian cancer, with a genotype phenotype correlation.
S K, Kachhap, S N, Ghosh
openaire   +1 more source

Association between single nucleotide polymorphisms of DNA repair genes (BRCA1, BRCA2, and PALB2) and breast cancer incidence in a subset of Iranian population. [PDF]

Hered Cancer Clin Pract
Jahangiri S, Abdan Z, Houshmand M, Souroush A, Aznab M.   +4 more
europepmc   +1 more source

Evaluation of healthcare management issues in the provision of clinical services for familial breast/ovarian cancer

, 2009
Electronic version does not contain associated previously published materialDespite there being pragmatic national guidelines for assigning risk to women with a family history of breast cancer, the evidence base is still sparse.
de Azevedo Moreira Reis, Marta
core  

Somatic BRCA1 Gene Mutation [PDF]

, 2020
openaire   +1 more source

Exploring Citrus sinensis Phytochemicals as Potential Inhibitors for Breast Cancer Genes BRCA1 and BRCA2 Using Pharmacophore Modeling, Molecular Docking, MD Simulations, and DFT Analysis. [PDF]

ACS Omega
Zia M, Parveen S, Shafiq N, Rashid M, Farooq A, Dauelbait M, Shahab M, Salamatullah AM, Brogi S, Bourhia M.   +9 more
europepmc   +1 more source

Clinicopathological characteristics and BRCA1/BRCA2 pathogenic variants of patients with breast cancer

Although BRCA genes are well-known breast cancer genes, the clinicopathological features of breast cancer patients carrying BRCA1/2 pathogenic variants have not been adequately defined.
Nazan Eras, Zuhal Altıntas, Ferah Tuncel, Sema Erden   +3 more
core   +1 more source

Germline BRCA1 Gene Mutation [PDF]

, 2020
openaire   +1 more source

Molecular architecture of the tumor microenvironment caused by <i>BRCA1</i> and <i>BRCA2</i> somatic mutations in human lung adenocarcinoma. [PDF]

Elife
Liao G, Yang X, Liu Q, Nan S, Liu Y, Li J, Huang S, Ning W, Qin X, Xu G.   +9 more
europepmc   +1 more source