Results 111 to 120 of about 1,685,955 (199)

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source

The Molecular Detection of Germline Mutations in the BRCA1 and BRCA2 Genes Associated with Breast and Ovarian Cancer in a Romanian Cohort of 616 Patients

Current Issues in Molecular Biology
The objective of this study was to identify and classify the spectrum of mutations found in the BRCA1 and BRCA2 genes associated with breast and ovarian cancer in female patients in Romania.
Liliana-Georgiana Grigore, Viorica-Elena Radoi, Alexandra Serban, Adina Daniela Mihai, Ileana Stoica   +4 more
doaj   +1 more source

Deciphering the Inflammatory Network in Pediatric Recurrent Tonsillitis: The Role of TRAF6, IRAK1, and miR‐146a‐5p

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To investigate the role of TNF receptor‐associated factor 6 (TRAF6), interleukin 1 receptor‐associated kinase 1 (IRAK1), and miR‐146a‐5p expression levels in the pathogenesis of recurrent tonsillitis. Study Design Case‐control study. Setting The study was conducted at the Department of Otorhinolaryngology, Muğla Training and Research
Ömer Faruk Güzel, Çilem Özdemir, Tuba Edgünlü, Ozan Gökdoğan   +3 more
wiley   +1 more source

GenProb‐PCSM: A Simplified Weighted Germline Score for Prostate Cancer‐Specific Mortality

The Prostate, EarlyView.
ABSTRACT Background We previously developed a tier‐based germline classification using the National Comprehensive Cancer Network (NCCN)‐recommended DNA damage repair (DDR) genes and KLK3 I179T to predict prostate cancer (PCa)‐specific mortality (PCSM).
Jun Wei, Zhuqing Shi, Lucy Lu, John Wang, Julian Xu, Ashley J. Mulford, Huy Tran, Annabelle Ashworth, S. Lilly Zheng, Alan R. Sanders, William B. Issacs, Jun Luo, Brian Helfand, Jim Lu, Jianfeng Xu   +14 more
wiley   +1 more source

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, EarlyView.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

Impact of sleep insufficiency and recovery on cancer development

Sleep Research, EarlyView.
Abstract Sleep plays a critical role in overall health, and modern lifestyles, such as shift work and late‐night activities, can significantly impact sleep condition. Insufficient sleep has been associated with various adverse health outcomes, including an increased risk of tumor development.
Xiaxi Li, Chuanyuan Li, Yi Zhang
wiley   +1 more source

Locating the Protein Binding Region of p53 and the Intrinsically Disordered Region of BRCA1

, 2022
BRCA1 and p53 have been shown to interact in tumor supressor pathways that protect against hereditary breast and ovarian cancer. Finding the physical binding location associated with this interplay is important in assessing cancer risk and determining ...
Norman, Anna
core  

Differentiating high‐ and low‐grade serous ovarian carcinoma using radiomics: a pilot study

Ultrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objective To identify ultrasound‐based radiomics features capable of distinguishing between high‐grade serous ovarian carcinomas (HGSC) and invasive low‐grade serous ovarian carcinomas (LGSC), and to develop machine‐learning models that include radiomics features to discriminate between the two.
F. Ciccarone, G. Zinicola, E. H. Tran, G. Baldassari, E. Boccia, C. Nero, F. Moro, T. Pasciuto, G. Scambia, G. Ferrandina, A. Fagotti, A. C. Testa, D. Lorusso, Collaborators, F. Borella, F. Buonomo, R. Fruscio, F. Pozzati   +17 more
wiley   +1 more source

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source

Investigating the Molecular Details of the Interaction between Two Tumor Suppressing Proteins, BRCA1 and P53 [PDF]

, 2019
Breast cancer type 1 protein (BRCA1) is a major risk factor for developing breast cancer. The BRCA1 protein is involved in many essential cellular pathways, including DNA double-strand break repair, cell cycle checkpoint control and induction of ...
Dao, Khoa Minh
core