Results 51 to 60 of about 1,685,955 (199)
SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin +17 morewiley +1 more sourceEvaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) [PDF]
, 2009 BACKGROUND: In this study we aimed to evaluate the role of a SNP in intron I of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and ...Rodriguez, GC, S V Blank, Gomez Garcia, E. B., O Barnett-Griness, Caligo, M A, de la Hoya, M.,, Schaefer, D.,, SWE-BRCA, Fricker, J. P., Imyanitov, E.N., Engel, C., H T Lynch, Spiess, A.C., Olivier-Faivre, L, Douglas, F., D Frost, E N Imyanitov, Rennert, G. (Gad), Meindl, A., Gschwantler-Kaulich, D. (Daphne), K Offit, De La Hoya, M., Couch, F.J. (Fergus), Milne, R.L. (Roger), Peyrat, JP, Schaefer, D., Johannsson, O.T., Ozcelik, H.,, Askmalm, M. S., Viel, A., Hogervorst, F. B.L., Bergman, Annika,, Arnold, N, Mai, P.L. (Phuong), C F Singer, Hopper, JL, Morrison, Patrick, Sinilnikova, O. M., Blank, S.V. (Stephanie), Weerasooriya, N.,, Group, EMBRACE, Douglas, F. (Fiona), M B Terry, A van den Ouweland, Dagan, E., Manoukian, S.,, Niederacher, D, Allavena, A., Froster, U.G. (U.), O M Sinilnikova, Versmold, B., Hansen, Thomas V.O., Revillion, F.,, Nevanlinna, H.,, Milne, R L, Radice, P.,, Boggess, J.F., Neuhausen, S.L. (Susan), Ding, Y C,, Easton, D F, Osorio, A, S Giraud, Dagan, E, Askmalm, M S, Evans, D.G. (Gareth), Benítez, J. (Javier), Muller, D, Rennert, G, Gómez García, EB, Claes, K.,, Moncoutier, V. (Virginie), Allavena, A, E M John, Moncoutier, V.,, L Barjhoux, F Révillion, Boggess, J F, Pita, G., Peyrat, J. -P, Antoniou, A C, Greene, M. H., S L Neuhausen, Wijnen, JT, Schwartz, P.E. (Peter), Hansen, T.v.O, Schaefer, D. (D.), A B Spurdle, Basil, J., Claes, K., Hopper, J. L., Fricker, J-P, Hansen, T.V., Milne, R.L., Eeles, R., Hopper, J.L., Cajal, T.R.Y., Godwin, AK, Buys, S., Varon-Mateeva, R, P Radice, Jernström, H. (H.), N. Imyanitov, E., Giraud, S. (Sophie), Fiebig, B.,, Montagna, M., Casella, C. (Cinzia), J Brunet, Group, GEMO, Barnett-Griness, O., A Meindl, Allavena, A. (Anna), S Peock, Simard, J. (Jacques), Jernström, Helena, van den Ouweland, A.,, Manoukian, S. (Siranoush), A E Toland, C Engel, Cassini, C., Peyrat, J-P,, Wang, X.,, Cruger, D G, Kaufman, B.,, Verhoef, S, Kirchhoff, T., Barnett-Griness, O.,, Blank, S V, Luccarini, C, A Osorio, Oliver, C T, Goldgar, D.,, Meindl, A, R Gershoni-Baruch, Pfeiler, G. (Georg), J Cook, Szabo, C.I., Kircchoff, T. (Tomas), E. Schwartz, P., Hamann, U. (Ute), Giraud, S, U G Froster, Boggess, JF, Arver, B. (Brita Wasteson), T. Johannsson, O.,, Kaufman, B. (Bella), Muller, D.W. (Danièle), Chen, X.C. (X. C.), G Pita, Tizzoni, L., Froster, U.G., Olivier-Faivre, L.,, Kosarin, K.,, Peterlongo, P, Oliver, C.T., Faivre, L. (Laurence), Milne, RL, Kosarin, K., Andrulis, I. L., Ozcelik, H, Manoukian, S., Antoniou, A.C. (Antonis), Peock, S. (Susan), Nathanson, K L,, Thomassen, M. (Mads), Domchek, SM, Pita, G. (Guillermo), Pfeiler, G.,, Tizzoni, L. (Laura), Schwartz, PE, Moncoutier, V., E Friedman, Mai, P., J Simard, Andrulis, I.L. (Irene), Caligo, MA, Heikinen, T. (Tuomas), Hogervorst, F.B., Schmutzler, RK, Gomez Garcia, E.B., F J Couch, Simard, J.,, Luccarini, C.,, Laitman, Y., Gerdes, A-M. (Anne-Marie), E. Toland, A.,, Spiess, A.-C., Ozcelik, H. (Hilmi), Garcia, E.B.G., Oliver, C.T. (Clare), Morrison, P J,, Eeles, R.,, Evans, D G,, S Cohen, Couch, F J, Domchek, S.M., Gomez Garcia, E B, Ditsch, N.,, B Arver, Caldes, T.,, Deissler, H., McGuffog, L. (Lesley), Weerasooriya, N, Hogervorst, F B L, Kirchhoff, T, Hansen, TV, Terry, MB, Frost, D., Spiess, A. C., Hansen, TVO, Hamann, U, Antoniou, AC, N Arnold, Spiess, AC, Luccarini, C. (Craig), Offit, K, Frost, D, Lynch, H T, Barjhoux, L. (Laure), Cook, J., Greene, M H, J-P Peyrat, F Douglas, Andrulis, I L,, EB Gómez García, Schmutzler, R. K., John, EM, KConFab, S Healey, D G Evans, Beesley, J.,, Caldes, T. (Trinidad), Claes, Kathleen, Beesley, J. (Jonathan), Nathanson, K.L. (Katherine), F Lejbkowicz, Offit, K.,, Kaufman, B, Wang, X, Muller, D., Heikkinen, T., Lalloo, F., Jernström, H, Evans, D G, Kontorovich, T. (Tair), G Pichert, Lalloo, F.,, Cook, M., Pichert, G., C. Rodriguez, G., Askmalm, M.S., B Malmer, Singer, C F, A-M Gerdes, Domchek, S M, C Cassini, Ding, Y. C., Yassin, Y. (Yosuf), Godwin, A.K. (Andrew), McGuffog, L., Buys, S, Weerasooriya, N. (Nayana), Spurdle, A B,, Miron, A., M Piedmonte, Miron, A. (Alexander), Gershoni-Baruch, R.,, Fricker, J.P., Laitman, Y.,, Caldes, T., Hamann, U.,, M Montagna, Sinilnikova, OM, Friedman, E.,, Pfeiler, G., Cruger, D.G., Ozcelik, H., G. Froster, U., Ditsch, N. (Nina), Froster, UG, Stoppa-Lyonnet, D., Peterlongo, P. (Paolo), Terry, M B,, Y C Ding, Toland, A E, Zikan, M., Daly, M.B. (Mary), L McGuffog, Pita, G.,, Versmold, B, Engel, C.,, Morrison, PJ, Oliver, C T,, J F Boggess, B Kaufman, Caldes, T, Hoya, M. (Miguel) de La, D Niederacher, A Allavena, Hogervorst, FB, Easton, D. F., Stoppa-Lyonnet, D, Peterlongo, P., Stoppa-Lyonnet, D. (Dominique), Caligo, M A,, Montagna, M, Viel, A. (Alessandra), Couch, F. J., Cook, M.,, G. Froster, U.,, GEMO, Zikan, M, Y Yassin, Wijnen, J.T., Family Registry, Breast Cancer, Rodriguez, G. C., Neuhausen, S.L., J Benítez, T Ramón y Cajal, Cruger, DG, Barjhoux, L.,, A C Antoniou, Pichert, G, J Beesley, Nathanson, K. L., S M Domchek, Benitez, J.,, Healey, S, Douglas, F.,, Ramon Y Cajal, T., P Peterlongo, EMBRACE, Group, HEBON, Toland, A.E., Group, KConFab, Greene, M.H., Nevanlinna, H., Hoya, M. de la, Boggess, J.F. (John), Ding, Y C, Gschwantler-Kaulich, D.,, Nathanson, K L, G Chenevix-Trench, Hodgson, S.,, Garcíla, E. B. G., Antoniou, A.C., N. Imyanitov, E.,, Blank, SV, Singer, CF, Yassin, Y.,, Friedman, E, Gerdes, A. M., Andrulis, IL, Mai, P.,, Fricker, J.P. (Jean Pierre), Breast Cancer Family Registry, Stenmark Askmalm, Marie, Lynch, H.T., Deissler, H.,, Wakeley, K., Goldgar, D., Claes, K, H Ozcelik, M Barile, Szabo, C. I., Barjhoux, L., Nevanlinna, H, Caligo, M.A. (Maria), Schmutzler, R K, Goldgar, D, Laitman, Y. (Yael), Nevanlinna, H. (Heli), Van Den Ouweland, A., Morrison, P. J., Pichert, G.,, Chen, X., Yannoukakos, D.,, Hansen, Thomas V O, Simard, J., Easton, D.F., Arver, B.,, Godwin, A K,, V. Blank, S., Johannson, O.T. (Oskar), Radice, P, Frost, D.,, Chenevix-Trench, G., Basil, J.,, Sinilnikova, O.M., Brunet, J.,, Ding, Y.C., U Hamann, K. Schmutzler, R.,, Cassini, C, Imyanitov, EN, Hansen, T.V.O. (Thomas), Hansen, T. V. O., Gerdes, A-M,, K. Schmutzler, R., H Deißler, Garcia, E.B. Gomez, Healey, S. (Sue), J-P Fricker, Sinilnikova, O M, C I Szabo, Foretova, L., Garcia, EBG, Gershoni-Baruch, R, Versmold, B.,, Fiebig, B. (Britta), M S Askmalm, Niederacher, D., F Lalloo, Fricker, JP, Zikan, M.,, Douglas, F, Barnett-Griness, O, Miron, A.,, Gomez Garcia, E B,, S Manoukian, Greene, MH, R L Milne, N Ditsch, Piedmonte, M, Kontorovich, T., J Basil, Rodriguez, G C, Chenevix-Trench, G.,, Greene, M.H. (Mark), Osorio, A.,, Friedman, E., Milne, R L,, Hopper, J L, Froster, U. G., R Eeles, Basil, J, Cassini, C. (C.), Blank, S.V., Lynch, H. (Henry), Morrison, P J, A-C Spiess, Spurdle, Amanda B., Spurdle, AB, Lynch, HT, Domchek, S.M. (Susan), v. O. Hansen, Thomas,, Godwin, A K, Ramón Y Cajal, T, Moncoutier, V, T Caldes, Sinilnikova, O M,, Wakeley, K.,, Evans, DG, John, E.M. (Esther), Hogervorst, F.B.L. (Frans), Giraud, S., v. O. Hansen, Thomas, D Yannoukakos, Peyrat, J. P., A Miron, Johannsson, O T, Terry, M. B., Miron, A, L Foretova, Chen, X.,, Piedmonte, M.,, M A Caligo, Fiebig, B, Schaefer, D, S Hodgson, Szabo, C I,, Spiess, A. -C, Kirchhoff, T.,, Andrulis, I L, Daly, M.,, Hogervorst, FBL, Cajal, T. Ramon y,, Oliver, CT, Casella, C., Ditsch, N, R Varon-Mateeva, John, E M, Spiess, A-C,, Group, SWE-BRCA, Gerdes, A.-M., Y Laitman, Pfeiler, G, Fricker, J. -P, Pita, G, Mai, P, Giraud, S.,, Kosarin, K. (Kristi), C Casella, Lejbkowicz, F. (Flavio), Yannoukakos, D. (Drakoulis), X Wang, Claes, K. (Kathleen), Buys, S. M., Révillion, F, Imyanitov, E.N. (Evgeny), Cruger, D. G., Schmutzler, R.K. (Rita), Ramon, Y.Cajal, K Wakeley, P Mai, Nathanson, K.L., Ditsch, N., Lindor, N.,, Arnold, N.,, Group, OCGN, G Rennert, Morrison, P.J., Chenevix-Trench, G, G Pfeiler, Arver, B., B Fiebig, Couch, FJ, Offit, K., Evans, D.G., Schwartz, P.E., Hogervorst, F. B. L., Ouweland, A.M.W. (Ans) van den, Malmer, Beatrice,, Eeles, R, Szabo, C I, Tizzoni, L, Healey, S., Hodgson, S., E. Toland, A., S Verhoef, Benítez, J, Singer, C F,, Montagna, M.,, Foretova, L.,, T Heikkinen, Engel, C, John, E. M., Dagan, E. (Efrat), V Moncoutier, Yannoukakos, D., M H Greene, Toland, A.E. (Amanda), Froster, U G, Domchek, S M,, Neuhausen, S. L., Cajal, T. Ramon y, Rennert, G.,, Kontorovich, T.,, Beesley, J, Meindl, A.,, McGuffog, L.,, Jernstrom, H., Heikkinen, T.,, OCGN, Malmer, B, J T Wijnen, K Kosarin, Johannsson, OT, Schwartz, P E, F. Boggess, J., Garcíla, EBG, Laitman, Y, Yannoukakos, D, Allavena, A.,, Couch, F.J., Hodgson, S.V. (Shirley), C T Oliver, Kontorovich, T, Szabo, CI, Niederacher, D.,, Daly, M., Chen, X, D Muller, Foretova, L, Yassin, Y., Hamann, U., Spurdle, A B, Toland, AE, T Kirchhoff, Wang, X., Peyrat, J.P., John, E M,, Barile, M, M Thomassen, Cruger, D. (Dorthe), Hansen, Thomas v. O., E Dagan, E. Schwartz, P.,, Caligo, M. A., Wakeley, K. (Katie), Buys, S.S. (Saundra), S Buys, Manoukian, S, Brunet, J., Spurdle, A.B., Benitez, J., A K Godwin, M Cook, Neuhausen, SL, Viel, A, Simard, J, Milne, R. L., Casella, C.,, Cohen, S.,, Lindor, N., Cook, J. (Jackie), Healey, S.,, Muller, D.,, M de la Hoya, Stoppa-Lyonnet, D.,, Ding, YC, Couch, F J,, Thomas v O Hansen, Lynch, H T,, CMBA, Thomassen, M.,, Verhoef, S.,, H Jernström, D Gschwantler-Kaulich, Peterlongo, P.,, Imyanitov, E. N., Brunet, J, Toland, A. E., Offit, K. (Kenneth), N Lindor, Rodriguez, G.C. (Gustavo), Arnold, N., Gerdes, A-M, D Schaefer, Garcíla, E.B.G. (E.B. Gómez), Thomassen, M, O T Johannsson, Rennert, G., Yassin, Y, Gershoni-Baruch, R., Cook, J.,, Gschwantler-Kaulich, D., Neuhausen, S L,, K Claes, C. Rodriguez, G.,, Tizzoni, L.,, Barjhoux, L, Revillion, F., Dagan, E.,, John, E.M., Malmer, B. (Beatrice), Brunet, J. (Joan), P E Schwartz, Easton, DF, Fiebig, B., Boggess, J. F., Terry, M.B., Piedmonte, M., Jernstrom, H.,, Hogervorst, F.B.L., Meindl, A. (Alfons), García, Eb Gómez, Blank, S. V., P J Morrison, C Luccarini, Hopper, J.L. (John), Singer, C.F., Casella, C, Singer, C.F. (Christian), Cassini, C.,, Askmalm, M.S. (Marie), Wijnen, J. T., Stenmark Askmalm, Marie,, Hogervorst, F B L,, D Stoppa-Lyonnet, Viel, A.,, Wang, X. (Xing), Spiess, E. (Eberhard), Nathanson, KL, Niederacher, D. (Dieter), Godwin, A.K., Heikkinen, T, Deiler, H. (H.), Verhoef, S., Varon-Mateeva, R., X Chen, H Nevanlinna, Andrulis, I.L., Caligo, M.A., Spiess, A-C, Johannsson, O. T., Lejbkowicz, F., Barile, M., Cohen, S, Sinilnikova, O. (Olga), Fricker, J-P,, Schmutzler, R.K., Olivier-Faivre, L., Goldgar, D. (David), Piedmonte, M. (Marion), Lalloo, F, Basil, J. (Jack), Terry, M B, Arnold, N. (Norbert), F B L Hogervorst, F. Boggess, J.,, Daly, M, Antoniou, A. C., Malmer, B., C. Antoniou, A., Cook, M, Beesley, J., Peock, S.,, Osorio, A. (Ana), B Versmold, Kaufman, B., Wakeley, K, Lynch, H. T., Cook, J, Szabo, C. (Csilla), Varon-Mateeva, R.,, Malmer, B.,, Pichert, G. (Gabriella), Cruger, D G,, Chenevix-Trench, G. (Georgia), R K Schmutzler, Peyrat, J-P, Easton, D F,, Kosarin, K, Oliver, C. T., Friedman, E. (Eitan), J L Hopper, Eeles, R. (Rosalind), Askmalm, MS, Lindor, N.M. (Noralane), Imyanitov, E N, de la Hoya, M, Hopper, J L,, Thomassen, M., Versmold, B. (Beatrix), Ouweland, A.M.W. van den, D G Cruger, Lalloo, F. (Fiona), Peyrat, J.-P., Gerdes, A. -M, Cajal, TRY, Zikan, M. (Michal), Montagna, M. (Marco), Easton, D.F. (Douglas), Lejbkowicz, F.,, Peock, S., Garcíla, E. B.Gómez, Weerasooriya, N., Cohen, S. (Shimrit), Morrison, P.J. (Patrick), Lejbkowicz, F, I L Andrulis, van den Ouweland, A, Ouweland, A. van den, Spurdle, A. B., Peock, S, Wijnen, J T, Hodgson, S, Révillion, F. (Françoise), L Olivier-Faivre, D F Easton, Gerdes, A.M., Luccarini, C., Radice, P. (Paolo), Wijnen, J.T. (Juul), Arver, B, Deissler, H, Domchek, S. M., HEBON, M Daly, M Zikan, V. Blank, S.,, Evans, D. G., Foretova, L. (Lenka), Osorio, A., Terry, M.-B. (Mary-Beth), Rodriguez, G.C., Radice, P., Buys, S.,, Gerdes, AM, Cook, M. (Margaret), Deiler, H., Wijnen, J T,, Cohen, S., Barile, M. (Monica), Frost, D. (Debra), Barnett-Griness, O. (Ofra), Godwin, A. K., T Kontorovich, D Goldgar, N Weerasooriya, Greene, M H,, McGuffog, L, K L Nathanson, G C Rodriguez, T. Johannsson, O., Nordling, Margareta,, Varon-Mateeva, R. (Raymonda), Lindor, N, Neuhausen, S L, Ding, Y.C. (Yuan), Singer, C. F., Spurdle, A.B. (Amanda), Schwartz, P. E., A Viel, C. Antoniou, A.,, Engel, C. (Christoph), Fricker, J.-P., Gschwantler-Kaulich, D, Barile, M.,, L Tizzoni, Osorio, A;Milne, RL;Pita, G;Peterlongo, P;Heikkinen, T;Simard, J;Chenevix-Trench, G;Spurdle, AB;Beesley, J;Chen, X;Healey, S;Neuhausen, SL;Ding, YC;Couch, FJ;Wang, X;Lindor, N;Manoukian, S;Barile, M;Viel, A;Tizzoni, L;Szabo, CI;Foretova, L;Zikan, M;Claes, K;Greene, MH;Mai, P;Rennert, G;Lejbkowicz, F;Barnett-Griness, O;Andrulis, IL;Ozcelik, H;Weerasooriya, N;Gerdes, AM;Thomassen, M;Cruger, DG;Caligo, MA;Friedman, E;Kaufman, B;Laitman, Y;Cohen, S;Kontorovich, T;Gershoni-Baruch, R;Dagan, E;Jernstrom, H;Askmalm, MS;Arver, B;Malmer, B;Domchek, SM;Nathanson, KL;Brunet, J;Ramón y Cajal, T;Yannoukakos, D;Hamann, U;Hogervorst, FB;Verhoef, S;Gómez García, EB;Wijnen, JT;van den Ouweland, A;Easton, DF;Peock, S;Cook, M;Oliver, CT;Frost, D;Luccarini, C;Evans, DG;Lalloo, F;Eeles, R;Pichert, G;Cook, J;Hodgson, S;Morrison, PJ;Douglas, F;Godwin, AK;Sinilnikova, OM;Barjhoux, L;Stoppa-Lyonnet, D;Moncoutier, V;Giraud, S;Cassini, C;Olivier-Faivre, L;Revillion, F;Peyrat, JP;Müller, D;Fricker, JP;Lynch, HT;John, EM;Buys, S;Daly, M;H, OCGN Investigators, Jernström, Helena,, Lucassen, Anneke, Lund University., et al., +815 morecore +1 more sourceTreatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran +6 morewiley +1 more sourceUse of Gene Expression Profiles of Peripheral Blood Lymphocytes to Distinguish BRCA1 Mutation Carriers in High Risk Breast Cancer Families
Cancer Informatics, 2009 Mutations in two major genes, BRCA1 and BRCA2, account for up to 30% of families with hereditary breast cancer. Unfortunately, in most families there is little to indicate which gene should be targeted first for mutation screening, which is labor ...Marie-Laure Vuillaume, Nancy Uhrhammer, Véronique Vidal, Valérie Sylvain Vidal, Valérie Chabaud, Beline Jesson, Fabrice Kwiatkowski, Yves-Jean Bignon +7 moredoaj Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...Anu Singh, Aroonima Misra, Sufian Zaheerwiley +1 more sourceThe androgen receptor CAG repeat polymorphism and modification of breast cancer risk in BRCA1 and BRCA2 mutation carriers [PDF]
, 2004 <p>Introduction: The androgen receptor (AR) gene exon 1 CAG repeat polymorphism encodes a string of 9–32 glutamines. Women with germline BRCA1 mutations who carry at least one AR allele with 28 or more repeats have been reported to have an earlier ...Antoniou, A.C., Spurdle, A.B., Cook, M.R., Purdie, David M., Susan Peock, Hopper, John L., Easton, Douglas, Newman, B, kConFaB, Antoniou, AC, Kelemen, Livia, Tobias, E.S., Smith, Paula, Pandeya, N, Giles, GG, Beth Newman, Giles, Graham, Chenevix-Trench, Georgia, Cook, Margaret, Apicella, Carmel, Nirmala Pandeya, Easton, Douglas F., Melissa C Southey, Southey, M.C., Antoniou, Antonis, Purdie, David, Chenevix-Trench, G, Cook, MR, Peock, Susan, Apicella, C., Giles, G.G., Apicella, C, Purdie, D.M., Xiaoqing Chen, Antoniou, Antonis C., David L Duffy, Margaret R Cook, Duffy, David, Newman, Beth, ABCFS, Duffy, D.L., Pandeya, N., Amanda B Spurdle, Dite, Gillian S., Giles, Graham G., Georgia Chenevix-Trench, Smith, Paula L., Newman, B., Gillian S Dite, Hopper, J.L., John L Hopper, Southey, MC, Chen, Xiaoqing, Chen, X., Cook, Margaret R., Chen, X, Duffy, David L., EMBRACE Study Collaborators, Purdie, DM, Hopper, JL, Easton, D.F., Dite, Gillian, Douglas F Easton, David M Purdie, Southey, Melissa, Smith, P.L., AJBCS, Chenevix-Trench, G., Dite, GS, Spurdle, Amanda, Peock, S., Antonis C Antoniou, Chevenix-Trench, Georgia, Dite, G.S., Spurdle, Amanda B., Carmel Apicella, Spurdle, AB, Kelemen, L., Pandeya, Nirmala, Smith, PL, Kelemen, L, Easton, DF, Southey, Melissa C., Paula L Smith, Hopper, John, Livia Kelemen, Duffy, DL, Peock, S, Graham G Giles +88 morecore +3 more sourcesModulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties
Advanced Science, EarlyView.Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen +16 morewiley +1 more source
