Results 21 to 30 of about 111,950 (304)

Evidence for Diverse Prognosis in High-Grade Serous Ovarian Carcinoma: Solid, Pseudoendometrioid, and Transitional-Like; So-Called "SET Morphology" and Progesterone Receptor Status

open access: yesTürk Patoloji Dergisi, 2022
Objective: High-grade serous ovarian carcinoma (HGSC) is one of the major tumors of the gynecological system with a poor survival rate and variable microscopic appearance.
Halit UNER   +5 more
doaj   +1 more source

A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes. [PDF]

open access: yes, 2002
In computing the probability that a woman is a BRCA1 or BRCA2 carrier for genetic counselling purposes, it is important to allow for the fact that other breast cancer susceptibility genes may exist.
P D P Pharoah   +15 more
core   +1 more source

BRCA1-BARD1: the importance of being in shape

open access: yesMolecular & Cellular Oncology, 2019
The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation.
Manuel Daza-Martin   +2 more
doaj   +1 more source

BRCA1 and BRCA2 mutations in a population-based study of male breast cancer [PDF]

open access: yes, 2001
Background: The contribution of BRCA1 and BRCA2 to the incidence of male breast cancer (MBC) in the United Kingdom is not known, and the importance of these genes in the increased risk of female breast cancer associated with a family history of breast ...
Bruce AJ Ponder   +13 more
core   +2 more sources

Spectrum of germline BRCA mutations in hereditary breast and ovarian cancer syndrome in Indian population: A central reference laboratory experience

open access: yesCancer Research, Statistics, and Treatment, 2020
Introduction: There is a growing need for BRCA1/BRCA2 mutation frequencies among hereditary breast and ovarian carcinoma (HBOC) cases, specifically determined on the grounds of personal and family history profiles in the Indian population.
Pratiksha Chheda   +7 more
doaj   +1 more source

A Multicenter Study of Genotype Variation/Demographic Patterns in 2475 Individuals Including 1444 Cases With Breast Cancer in Turkey

open access: yesEuropean Journal of Breast Health, 2023
Objective:Breast cancer (BC) is the most common cancer type in women and may be inherited, mostly in an autosomal dominant pattern. The clinical diagnosis of BC relies on the published diagnostic criteria, and analysis of two genes, BRCA1 and BRCA2 ...
Ibrahim Boga   +36 more
doaj   +1 more source

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. [PDF]

open access: yes, 2014
Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of ...
Backes, F.J. (Floor)   +999 more
core   +4 more sources

The Impact of Capecitabine and Combined Training on BRCA1 Gene Expression in Breast Cancer Induction [PDF]

open access: yesJournal of Basic Research in Medical Sciences, 2023
Introduction: This study explores the combined effects of concurrent training and capecitabine consumption on breast cancer prevention and therapy, focusing on the modulation of BRCA1 gene expression.
Masoud Shokuhi Niya   +3 more
doaj  

The PARP-1 inhibitor Olaparib causes retention of γ-H2AX foci in BRCA1 heterozygote cells following exposure to gamma radiation [PDF]

open access: yes, 2013
This article is made available through the Brunel Open Access Publishing Fund. Copyright © 2013 Emma C. Bourton et al. This is an open access article distributed under the Creative Commons Attribution Li-cense, which permits unrestricted use ...
Bourton, EC   +4 more
core   +1 more source

CLINICAL AND MORPHOLOGICAL FEATURES OF HEREDITARY OVARIAN CANCER

open access: yesСибирский онкологический журнал, 2017
Germ-line mutations in BRCA1 and BRCA2 genes are the most established risk factors for hereditary breast and ovarian cancers. The purpose of the study was to analyze BRCA1/2 testing in ovarian cancer patients. Materials and methods.
K. B. Kotiv   +16 more
doaj   +1 more source

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