Results 21 to 30 of about 143,588 (347)

Expression of DNAJB9 and some other genes is more sensitive to SWCNTs in normal human astrocytes than glioblastoma cells

Endocrine Regulations, 2023
Objective. Single-walled carbon nanotubes (SWCNTs) are considered to be one of the nanomaterials attractive for biomedical applications, particularly in the health sciences as imaging probes and drug carriers, especially in the field of cancer therapy ...
Minchenko Dmytro O., Rudnytska Olha V., Khita Olena O., Kulish Yuliia V., Viletska Yuliia M., Halkin Oleh V., Danilovskyi Serhiy V., Ratushna Oksana O., Minchenko Oleksandr H.   +8 more
doaj   +1 more source

Diagnosis and treatment of ovarian cancer in the light of modern molecular genetic achievements

Сибирский онкологический журнал, 2023
The purpose of the study was to systematize and summarize the literature data on the study of clinical and genetic aspects, molecular pathogenesis, as well as new trends in the diagnosis and treatment of ovarian cancer.Material and Methods.
E. M. Kagirova, R. I. Khusainova, I. R. Minniakhmetov   +2 more
doaj   +1 more source

BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies

Frontiers in Cell and Developmental Biology, 2022
Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other important physiological processes. Mutations or defects in the
Xiaoyu Fu, Wei Tan, Q. Song, Huadong Pei, Juanjuan Li   +4 more
semanticscholar   +1 more source

BRCA1 ve BRCA2 Mutasyonlarının Tespitine Yönelik Yeni Nesil Dizileme Temelli Kit Geliştirilmesi ve Rutinde Kullanılan Yöntemler ile Valide Edilmesi

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, 2021
Amaç: Meme kanseri, kadınlarda en yaygın görülen kanser türü olup, Göğüs Kanseri Duyarlılık gen (BRCA1 ve BRCA2) mutasyonlarının meme ve yumurtalık kanserlerinin önemli bir kısmından sorumlu olduğu bilinmektedir.
İlter Güney, Gözde Girgin Özgümüş
doaj   +1 more source

Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development

Molecular & Cellular Oncology, 2020
We recently developed a Brca1 coiled-coil mutant mouse model (Brca1CC). Brca1CC/CC results in embryonic lethality, with a fraction of mice reaching birth but with defects that parallel Fanconi anemia.
J. J. Krais, N. Johnson
doaj   +1 more source

The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells

Genes & Development, 2021
In this study, Simoneau et al. investigated why PARPi is more effective than other DNA-damaging drugs when used to treat BRCA1/2-deficient tumors. They show that PARPi induces DSBs progressively through trans-cell-cycle ssDNA gaps, and BRCA1/2-deficient ...
A. Simoneau, Rosalinda Xiong, L. Zou
semanticscholar   +1 more source

RPA, RFWD3 and BRCA2 at stalled forks: a balancing act

Molecular & Cellular Oncology, 2020
We recently identified E3 ligase RFWD3 as a modulator of stalled fork stability in BRCA2-deficient cells. We also show that BRCA1 might function upstream of BRCA2 during fork repair and that blocking fork degradation by depleting MRE11 does not guarantee
Haohui Duan, Shailja Pathania
doaj   +1 more source

Limited Independent Follow-Up with Germline Testing of Variants Detected in BRCA1 and BRCA2 by Tumor-Only Sequencing [PDF]

Journal of Immunotherapy and Precision Oncology
Introduction Genomic profiling is performed in patients with advanced or metastatic cancer, in order to direct cancer treatment, often sequencing tumor-only, without a matched germline comparator.
Carol J. Nowlen, Molly Daniels, Burak Uzunparmak, Ecaterina E. Ileana Dumbrava, Ying Yuan, Keyur P. Patel, Nadine Rayes, Jacqueline Harkenrider, Chetna Wathoo, Jennifer Veazie, Krystle A. Luna, Wanlin Wang, Chacha Horombe, Milind Javle, Jordi Rodon Ahnert, Timothy A. Yap, Banu Arun, Karen H. Lu, Funda Meric-Bernstam   +18 more
doaj   +1 more source

BRCA1 is a histone-H2A-specific ubiquitin ligase [PDF]

, 2014
The RING domain proteins BRCA1 and BARD1 comprise a heterodimeric ubiquitin (E3) ligase that is required for the accumulation of ubiquitin conjugates at sites of DNA damage and for silencing at DNA satellite repeat regions. Despite its links to chromatin,
Donna L. Mallery, Mallery, D., Conor Larkin, Huang, Jeffrey T.J., Kalb, R., Kevin Hiom, Kalb, Reinhard, Reinhard Kalb, Huang, Jeffrey T. J.; id_orcid, Hiom, Kevin, Hiom, K., Jeffrey T.J. Huang, Larkin, C., Mallery, Donna L., Larkin, Conor, Huang, J.   +15 more
core   +1 more source

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage

Nature Communications, 2021
R-loop structures act as modulators of physiological processes such as transcription termination, gene regulation, and DNA repair. However, they can cause transcription-replication conflicts and give rise to genomic instability, particularly at telomeres,
Jekaterina Vohhodina, Liana J Goehring, Ben Liu, Qing Kong, Vladimir V. Botchkarev, Mai Huynh, Zhiqi Liu, Fieda Abderazzaq, Allison P. Clark, S. Ficarro, Jarred Marto, E. Hatchi, D. Livingston   +12 more
semanticscholar   +1 more source