Results 81 to 90 of about 68,702 (192)
β-Glucan Regulates Lipopolysaccharide Induced Genotoxic Damage to The Liver through The Induction of BRCA1 Protein Expression. [PDF]
Cell J, 2023 Kılıç GA, Alsafi M.
europepmc +1 more source
BRCA1 interacts with poly(A)-binding protein: implication of BRCA1 in translation regulation.
The Journal of biological chemistry, 2006 BRCA1 has been implicated in a number of cellular processes, including transcription regulation, DNA damage repair, cell cycle control, and apoptosis. We identified poly(A)-binding protein 1 (PABP) as a novel BRCA1-interacting protein in a yeast two-hybrid screen and confirmed the interaction by in vitro assays and coimmunoprecipitation in mammalian ...
Eva, Dizin +6 more
openaire +1 more source
PLoS ONE, 2014 The identification of variants of unknown clinical significance (VUS) in the BRCA1 gene complicates genetic counselling and causes additional anxiety to carriers. In silico approaches currently used for VUS pathogenicity assessment are predictive and often produce conflicting data.
Christou, Charita M. +7 more
openaire +4 more sources
iNew Medicine, EarlyView.ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid +4 more
wiley +1 more source
BRCA1-BARD1: the importance of being in shape
Molecular & Cellular Oncology, 2019 The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation.
Manuel Daza-Martin +2 more
doaj +1 more source
BRCA1 Accelerates CtIP-Mediated DNA-End Resection
Cell Reports, 2014 DNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In higher eukaryotes, CtIP regulates resection by integrating cellular signals via its posttranslational modifications and protein-protein ...
Andrés Cruz-García +2 more
doaj +1 more source
Breast Cancer Susceptibility Gene1 (BRCA1) [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2002 Breast Cancer Susceptibility Gene1 (BRCA1) is a tumor suppressor gene for breast and ovarian cancers. The gene locates at chromosome 17q21 and encodes for 1863 amino acids protein.
Wasiksiri, S., Ratanaphan, A.
doaj
Neoplasia: An International Journal for Oncology Research, 2018 Germline BRCA1 or BRCA2 mutations (mtBRCA1 and mtBRCA2) increase risk for high-grade serous ovarian cancer (HGSOC), the most commonly diagnosed epithelial ovarian cancer histotype. Other identified risk factors for this cancer, which originates primarily
Julia Hollingsworth +12 more
doaj +1 more source
Cell ReportsSummary: Predicting the risk of cancer mutations is critical for early detection and prevention, but differences in allelic severity of human carriers confound risk predictions.
Brant Gracia +4 more
doaj +1 more source
From mechanism to phenotype: What fits in a basket trial
Epilepsia, EarlyView.
Kette D. Valente
wiley +1 more source