Results 101 to 110 of about 74,972 (273)

Population testing for cancer predisposing BRCA1/BRCA2 mutations

, 2014
Background: Technological advances raise the possibility of systematic population-based genetic testing for cancer-predisposing mutations, but it is uncertain whether benefits outweigh disadvantages.
Wardle, J
core  

Graph centrality of BRCA1 in Protein-Protein Interaction network: An Overview

, 2021
Cancer is a leading cause of death and around 10 million people died in 2020. In terms of new cases reported in 2020, leading was breast cancer with 2.26 billion cases.  In most cases, reason for the disease is stated as a germline mutation on tumor
et.al, Sminu Izudheen,
core   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

BAP1 (BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)) [PDF]

, 2010
Review on BAP1 (BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)), with data on DNA, on the protein encoded, and where the gene is ...
Durocher, F, F Guénard, F Durocher, Guénard, F   +3 more
core   +1 more source

BRCA1 frameshift variants leading to extended incorrect protein C termini

, 2023
Summary: Carriers of BRCA1 germline pathogenic variants are at substantially higher risk of developing breast and ovarian cancer than the general population.
Anna von Wachenfeldt, Gutierrez, Diana, Richardson, Marcy E., Marcelo A. Carvalho, Edwin Iversen, Borg, Åke, Nepomuceno, Thales C., Armel, Susan, Carvalho, Marcelo A., Monteiro, Alvaro N.A., Xia, Bing, Daniel Eriksson, Tzeh Keong Foo, Raymond Kim, Fergus J. Couch, Varga, Matthew J., Bing Xia, von Wachenfeldt, Anna, Iversen, Edwin, Thales C. Nepomuceno, Diana Gutierrez, Marcy E. Richardson, Amaya Alarcon, Alarcon, Amaya, Weyandt, Jamie, Ranola, John Michael O., Foo, Tzeh Keong, Alvaro N.A. Monteiro, Couch, Fergus J., Matthew J. Varga, Monteiro, Alvaro N. A., Kim, Raymond, Jamie Weyandt, Susan Armel, Eriksson, Daniel, John Michael O. Ranola, Åke Borg, Keong Foo, Tzeh   +37 more
core   +1 more source

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Posttranscriptional Regulation of the Breast Cancer Susceptibility Gene BRCA1 by the RNA Binding Protein HuR

, 2008
BRCA1 is a breast cancer susceptibility gene that is down-regulated in a significant proportion of sporadic breast cancers. BRCA1 is posttranscriptionally regulated by RNA-binding proteins, the identities of which are unknown.
Stein, SR, Leedman, PJ, Saunus, JM, French, JD, Simpson, KJ, Hatchell, EC, Davidson, A, Wagner, SA, Francis, GD, Edwards, SL, Beveridge, DJ, Brown, MA   +11 more
core   +1 more source

The Diagnostic Value of Immunohistochemistry and Biomarkers in the Diagnosis of Mesothelioma in Pleural/Peritoneal Effusions

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background Mesothelioma is a rare tumor that arises from the serosal cells lining the serous cavities, most commonly the pleura followed by the peritoneum. Presenting symptoms include pleuritic pain and bloody effusions that recur. Although cytologic analysis cannot determine the mesothelial subtype or in situ from invasive disease, the ...
Suzanne M. Selvaggi
wiley   +1 more source

Investigating the Molecular Details of the Interaction between Two Tumor Suppressing Proteins, BRCA1 and P53

, 2019
Breast cancer type 1 protein (BRCA1) is a major risk factor for developing breast cancer. The BRCA1 protein is involved in many essential cellular pathways, including DNA double-strand break repair, cell cycle checkpoint control and induction of ...
Dao, Khoa Minh
core  

Mutations in pathways depending on BRCA1 and BRCA2 may increase cancer risks from an environmental carcinogen

, 2011
Recently, the President’s Cancer Panel [2008-2009] protested that preventive action is not taken when uncertainty exists about potential harm from a chemical, because the US regulatory approach demands that a hazard be incontrovertibly ...
Bernard Friedenson
core   +1 more source