Results 81 to 90 of about 111,862 (289)

Identification of BRCA1 Deficiency Using Multi-Analyte Estimation of BRCA1 and Its Repressors in FFPE Tumor Samples from Patients with Triple Negative Breast Cancer. [PDF]

PLoS ONE, 2016
Apart from germ-line BRCA1-mutated breast cancers, a significant proportion of women with sporadic triple negative breast cancer (TNBC) sub-type are known to harbour varying levels of BRCA1-dysfuction.
Aruna Korlimarla, Jyothi S Prabhu, Jose Remacle, Savitha Rajarajan, Uma Raja, Anupama C E, B S Srinath, Suraj Manjunath, Gopinath K S, Marjorrie Correa, Prasad M S N, T S Sridhar   +11 more
doaj   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

EPMA position paper in cancer:current overview and future perspectives [PDF]

, 2015
At present, a radical shift in cancer treatment is occurring in terms of predictive, preventive, and personalized medicine (PPPM). Individual patients will participate in more aspects of their healthcare.
Bubnov, Rostylav, Danesi, Romano, Desiderio, Dominic M., Grech, Godfrey, Hagan, Suzanne, Vittadini, Giorgio, Yoo, Byong Chul, Zhan, Xianquan   +7 more
core   +5 more sources

USP9X stabilizes BRCA1 and confers resistance to DNA‐damaging agents in human cancer cells

Cancer Medicine, 2019
BRCA1, a multifunctional protein with an important role in DNA double‐strand break repair by homologous recombination (HR), is subjected to ubiquitin‐dependent degradation.
Qin Lu, Fang‐Lin Zhang, Da‐Yun Lu, Zhi‐Ming Shao, Da-Qiang Li   +4 more
doaj   +1 more source

Supplementary Figure 1 from BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer Activity

, 2023
Supplementary Figure 1 from BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer ...
Tomohiko Ohta, Mamoru Fukuda, Hiromichi Gomi, Ryoko Kojima, Ayaka Koike, Wenwen Wu, Hiroyuki Nishikawa   +6 more
openaire   +1 more source

End‐to‐End Sensing Systems for Breast Cancer: From Wearables for Early Detection to Lab‐Based Diagnosis Chips

Advanced Materials Technologies, EarlyView.
This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane, Lyn I. Jones, Richard M. Martin, Helen Winter, Faezeh Arab Hassani   +4 more
wiley   +1 more source

Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells. [PDF]

, 2019
Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding ...
Brooks, George A, Julian, Colleen G, Martinez, Janel, Matarazzo, Christopher, San-Millán, Iñigo   +4 more
core   +1 more source

PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells

Journal of Experimental & Clinical Cancer Research, 2018
Background The poly ADP ribose polymerase (PARP) inhibitor olaparib has been approved for treating prostate cancer (PCa) with BRCA mutations, and veliparib, another PARP inhibitor, is being tested in clinical trials.
Linglong Yin, Youhong Liu, Yuchong Peng, Yongbo Peng, Xiaohui Yu, Yingxue Gao, Bowen Yuan, Qianling Zhu, Tuoyu Cao, Leye He, Zhicheng Gong, Lunquan Sun, Xuegong Fan, Xiong Li   +13 more
doaj   +1 more source

Co-Relation of Hormonal Profile and BRCA1 in Sporadic Breast Carcinoma: A Single Institutional Experience of 303 Patients

Clinical Pathology, 2022
Introduction: Invasive Breast carcinoma—No special type (NST) is the most common breast malignancy accounting for 95% of breast cancers. Study of predictive and prognostic immunohistochemical markers estrogen receptor (ER), progesterone receptor (PR ...
Preeti Agarwal, Fatima Khan, Sameer Gupta, Shalini Bhalla, Ann Thomas, Akshay Anand, Kulranjan Singh, Abhinav Arun Sonkar   +7 more
doaj   +1 more source

Rapid detection of BRCA1 mutations by the protein truncation test [PDF]

Nature Genetics, 1995
More than 75% of the reported mutations in the hereditary breast and ovarian cancer gene, BRCA1, result in truncated proteins. We have used the protein truncation test (PTT) to screen for mutations in exon 11, which encodes 61% of BRCA1. In 45 patients from breast and/or ovarian cancer families we found six novel mutations: two single nucleotide ...
Hogervorst, FBL, Cornelis, RS, Bout, M, van Vliet, M, Oosterwijk, JC, Olmer, R, Bakker, B, Klijn, JGM, Vasen, HFA, Meijers Heijboer, H, Menko, FH, Cornelisse, CJ, den Dunnen, JT, Devilee, P, van Ommen, GJB   +14 more
openaire   +4 more sources