Results 121 to 130 of about 74,972 (273)
International Journal of Cancer, EarlyView.ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to its asymptomatic progression, late‐stage diagnosis, and treatment resistance. Efforts in early detection have centered on identifying imaging features and liquid biopsy biomarkers capable of detecting PDAC and its high‐grade precursors before clinical symptoms ...
Christine Worthington +105 more
wiley +1 more source
Personality correlates of P53, c-erbB-2, BRCA1 protein expression in breast cancer patients
, 2004 In this work, the associations between personality trait and gene protein expressions were evaluated in seventy women with breast cancer. The personality traits of these patients were examined with the Eysenck Personality Questionnaire (EPQ) before ...
W. J. Lin, J. P. Liu, Y. Liu
core
Neoplasia: An International Journal for Oncology Research, 2018 Germline BRCA1 or BRCA2 mutations (mtBRCA1 and mtBRCA2) increase risk for high-grade serous ovarian cancer (HGSOC), the most commonly diagnosed epithelial ovarian cancer histotype. Other identified risk factors for this cancer, which originates primarily
Julia Hollingsworth +12 more
doaj +1 more source
International Journal of Cancer, EarlyView.While current guidelines recommend the analysis of established cancer driver genes in brain metastases, little is known about its real‐life implementation. This multicenter study revealed an upward trend in the profiling rates of surgically treated brain metastases over the past decade, with up to 60% of brain metastases samples undergoing analysis ...
Maria Nikolaeva +25 more
wiley +1 more source
Effects of BRCA1 on Smad3 protein.
, 2013 (A) Wild type BRCA1 and Smad3 cooperate to increase p3TP-Lux promoter activity. 0.1 µg of p3TP-Lux and 10 ng of pCMVβ-galactosidase plasmids were co-transfected with 10 ng of Flag-Smad3, 50 ng of HA-Smad4, and 0.1 µg of wild type HA-BRCA1 plasmids into ...
Hava Karsenty Avraham (32550) +4 more
core +1 more source
Nanopore direct RNA sequencing and the epitranscriptome: Advances in mapping native RNA landscapes
iMeta, EarlyView.Nanopore direct RNA sequencing advances transcriptomics by capturing full‐length transcripts and multiple RNA modifications; this review details its principles, workflows, tools, applications, challenges, and future research potential. Abstract Nanopore direct RNA sequencing (DRS) has transformed transcriptomics by enabling single‐molecule, long‐read ...
Tianyuan Zhang +27 more
wiley +1 more source
Breast Cancer Susceptibility Gene1 (BRCA1) [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2002 Breast Cancer Susceptibility Gene1 (BRCA1) is a tumor suppressor gene for breast and ovarian cancers. The gene locates at chromosome 17q21 and encodes for 1863 amino acids protein.
Wasiksiri, S., Ratanaphan, A.
doaj
BRCA1-BARD1: the importance of being in shape
Molecular & Cellular Oncology, 2019 The breast cancer type-1 susceptibility protein (BRCA1) contributes to genome integrity through homologous recombinational DNA repair and by protecting stalled replication forks from nucleolytic degradation.
Manuel Daza-Martin +2 more
doaj +1 more source
iNew Medicine, EarlyView.ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid +4 more
wiley +1 more source
Strong preference of BRCA1 protein to topologically constrained non-B DNA structures
, 2016 Background: The breast and ovarian cancer susceptibility gene BRCA1 encodes a multifunctional tumor suppressor protein BRCA1, which is involved in regulating cellular processes such as cell cycle, transcription, DNA repair, DNA damage response and ...
Liao, Jack C. C. +14 more
core +1 more source