Results 111 to 120 of about 74,972 (273)

c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells

BMC Cancer, 2011
Background The BRCA1 gene plays an important role in the maintenance of genomic stability. BRCA1 inactivation contributes to breast cancer tumorigenesis. An increasing number of transcription factors have been shown to regulate BRCA1 expression.
Huo Dezheng, Collins Cindy, Borowicz Stanley, Xu Jinhua, Chen Yinghua, Olopade Olufunmilayo I   +5 more
doaj   +1 more source

β-Glucan Regulates Lipopolysaccharide Induced Genotoxic Damage to The Liver through The Induction of BRCA1 Protein Expression. [PDF]

Cell J, 2023
Kılıç GA, Alsafi M.
europepmc   +1 more source

Data from BRCA1-Associated Protein 1 Interferes with BRCA1/BARD1 RING Heterodimer Activity

, 2023
<div>Abstract<p>The breast and ovarian tumor suppressor BRCA1 constitutes a RING heterodimer E3 ligase with BARD1. BRCA1-associated protein 1 (BAP1) is a ubiquitin COOH-terminal hydrolase that was initially identified as a protein that bound to the RING finger domain of BRCA1.
Tomohiko Ohta, Mamoru Fukuda, Hiromichi Gomi, Ryoko Kojima, Ayaka Koike, Wenwen Wu, Hiroyuki Nishikawa   +6 more
openaire   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Methylation plots comparing blood and tumour for BRCA1-like features, Triple negativity and BRCA1 protein expression.

, 2016
Mean (+/-SD) methylation levels plotted against CpG site position along the chromosome in relation to the BRCA1 transcription start site (position zero). Blood methylation level is shown on the left and tumour methylation level on the right. A&B: Tumours
Daniel D. Connley (3146709), Ian W. Brock (146729), Philip Chambers (3146730), Olena Dotsenko (3146724), Octavia Wilks (3146718), Simon S. Cross (89942), Sarah L. Daniels (3146727), George J. Burghel (498991), Lynda Wyld (3146721), Angela Cox (76913), Helen E. Cramp (3146712), Shadi Al-Baba (3146715)   +11 more
core   +1 more source

BRCA1(185delAG) tumors may acquire therapy resistance through expression of RING-less BRCA1 [PDF]

, 2016
Heterozygous germline mutations in breast cancer 1 (BRCA1) strongly predispose women to breast cancer. BRCA1 plays an important role in DNA double-strand break (DSB) repair via homologous recombination (HR), which is important for tumor suppression ...
Taniguchi, T. (Toshiyasu), Serra, Violeta, Rottenberg, Sven, Brandsma, Inger, Dekkers, Dick H W, Dafni Chondronasiou, Burg, E, Klarenbeek, Sjoerd, Cruz, C. (Cristina), van Deemter, L, Elkon, R. (Ran), Dekkers, D.H. (Dick), Chondronasiou, D, Wientjens, Ellen, Jonkers, J, Cruz, C, Eline van der Burg, Fabricio Loayza-Puch, Castroviejo-Bermejo, Marta, Pieterse, M, Boon, U. (Ute), Jonkers, Jos, Ute Boon, Christiaan Klijn, Klarenbeek, S, Balmaña, Judith, Cristina Cruz, Drost, R, Rinske Drost, Castroviejo-Bermejo, M. (Marta), van Deemter, Liesbeth, Serra, V, Elkon, Ran, Bouwman, P, Serra, V. (Violeta), Toshiyasu Taniguchi, Inger Brandsma, Agami, R. (Reuven), Boon, Ute, Jeroen A.A. Demmers, Pieterse, Mark, Peter Bouwman, Rottenberg, S. (Sven), Balmana, J. (Judith), Burg, E. (Eline) van der, Ingrid van der Heijden, Bouwman, Peter, Marieke van de Ven, Dekkers, Dick, van de Ven, Marieke, Judith Balmaña, Wientjens, E. (Ellen), Jonkers, J. (Jos), van der Gulden, H, Schut, E, Ven, H.W.M. (Marieke) van de, Marta Castroviejo-Bermejo, van Gent, Dik C, Dhillon, K.K. (Kiranjit K.), Kiranjit K. Dhillon, Klijn, Christiaan, Hanneke van der Gulden, Rottenberg, S, Loayza-Puch, F. (Fabricio), Balmana, J, Ellen Wientjens, van Gent, Dik; id_orcid, Taniguchi, T, Mark Pieterse, Klijn, C. (Christiaan), Chondronasiou, Dafni, Dick H.W. Dekkers, Van Der Heijden, I. (Ingrid), Cruz, Cristina, van Gent, Dik, Van Deemter, L. (Liesbeth), Dhillon, KK, Elkon, R, Van Der Gulden, H. (Hanneke), Loayza-Puch, F, Schut, E. (Eva), Klarenbeek, S. (Sjoerd), van de Ven, M (Marieke), Drost, Rinske, van der Heijden, Ingrid, Wientjens, E, Boon, U, van der Burg, Eline, Agami, R, Sjoerd Klarenbeek, Ran Elkon, van der Heijden, I, Loayza-Puch, Fabricio, Klijn, C, Taniguchi, Toshiyasu, Castroviejo-Bermejo, M, Demmers, Jeroen, Reuven Agami, Violeta Serra, Brandsma, I. (Inger), Jos Jonkers, Dhillon, Kiranjit K, van der Gulden, Hanneke, Schut, Eva, Agami, Reuven, Bouwman, P. (Peter), Demmers, Jeroen A A, Gent, D.C. (Dik) van, Dik C. van Gent, Pieterse, M. (Mark), Sven Rottenberg, Liesbeth van Deemter, Eva Schut, Drost, R. (Rinske), Demmers, J.A.A. (Jeroen), Chondronasiou, D. (Dafni)   +115 more
core   +1 more source

MUC1 as a Survival Effector of Radiotherapy‐Induced Epithelial Hybrid States in Basal‐Like Breast Cancer

International Journal of Cancer, EarlyView.
Basal‐like breast cancer (BLBC) is aggressive and often exhibits inherent or acquired resistance to radiotherapy (RT), a primary treatment option. RT resistance is underpinned by molecular alterations, many of which are poorly understood. Here, RT‐induced transcriptomic changes were analyzed using bulk and spatial sequencing in a BLBC mouse model and ...
Garyfallia Pantelaiou‐Prokaki, Husam Bamahmoud, Nadine S. Georges, Shaishavi Jansari, Annika Jung, Daniela Grimm, Evangelos Prokakis, Fabian Alexander Gayer, Maryam Deldar, Christian Dullin, Julia Gallwas, Florian Wegwitz, Frauke Alves   +12 more
wiley   +1 more source

The alternative protein AltMRVI1 interacts with BRCA1.

, 2013
(A) Sequence alignment between the third BRCA1 interacting protein 3 (BRCA1 IP3) identified by Liu et al by Y2H [40] and AltMRVI1. (B) Localization of BRCA1 and AltMRVI1EGFP in the nucleus.
Cyntia Bissonnette (444451), Solène Vanderperre (444452), Michel Salzet (116871), Xavier Roucou (429985), Julie Motard (196516), Guillaume Tremblay (429984), François-Michel Boisvert (444453), Jean-François Lucier (9042), Benoît Vanderperre (444450), Maxence Wisztorski (116867)   +9 more
core   +1 more source

Tumor Infiltrating Lymphocyte Therapy Combined With PD‐1/LAG‐3 Inhibition in Patients With Recurrent Platinum‐Resistant Ovarian Cancer

International Journal of Cancer, EarlyView.
The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg, Cathrine L. Lorentzen, Marie C. W. Westergaard, Trine Z. Iversen, Troels H. Borch, Marco Donia, Sigrid M. Mannering, Stine E. W. Banke, Özcan Met, Inge Marie Svane   +9 more
wiley   +1 more source

BRCA1 Accelerates CtIP-Mediated DNA-End Resection

Cell Reports, 2014
DNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In higher eukaryotes, CtIP regulates resection by integrating cellular signals via its posttranslational modifications and protein-protein ...
Andrés Cruz-García, Ana López-Saavedra, Pablo Huertas   +2 more
doaj   +1 more source