Results 141 to 150 of about 74,972 (273)
Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development
Cancer Science, EarlyView.Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura +3 more
wiley +1 more source
Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in Cypriot population.
, 2010 Inability to correctly repair DNA damage is known to play a role in the development of breast cancer. Single nucleotide polymorphisms (SNPs) of DNA repair genes have been identified, which modify the DNA repair capacity, which in turn may affect the risk
Daniel, M +9 more
core
Cancer Science, EarlyView.Copy number variation analysis in The Cancer Genome Atlas identified NTAQ1 as a potential driver of HCC progression. NTAQ1 accelerates tumor growth by promoting the degradation of the tumor suppressor protein PRDM2, thereby impairing DNA repair and suppressing apoptosis. These findings indicate that NTAQ1 could be a valuable target for the treatment of
Tomohiko Ikehara +21 more
wiley +1 more source
Flow cytometric analysis of BRCA1 protein in sporadic breast cancer
, 1997 의학과/석사[한글] 유방암은 여성에서 흔하게 발생되는 종양으로 가족성 유방암과 산발성 유방암으로 나눌 수 있으며 가족성 유방암의 45% 이상에서 염색체 17번의 q21에 존재하는 BRCA1 유전자의 변이가 관찰되고 있다. BRCA1 유전자에 관한 연구는 실제 일부 유방암 가계에서 젊은 연령, 양측 발생, 남자에서 발생되는 점을 관찰하여 이에 대한 연관 분석을 함으로써 이루어졌다. 최근 BRCA1유전자의 구조 및 염기 서열이 완전히 밝혀졌고 BRCA1
이승무
core
Cancer Science, EarlyView.Multi‐region sequencing of 57 BRCA1‐associated breast cancers identified TP53 as the dominant initial driver, defining a triple‐negative subgroup with biallelic BRCA1 loss and elevated genomic instability. TP53 truncating mutations were enriched in BRCA1 carriers and linked to reduced HRD, EMT activation, and a trend toward worse survival.
Li Hu +13 more
wiley +1 more source
Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency
Clinical Endocrinology, EarlyView.ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh +4 more
wiley +1 more source
Molecular details of the BRCA1 interaction with estrogen receptor alpha (ERa)
Estrogen receptor alpha (ER) and BRCA1 play an important role in the development of breast cancer, and multiple pathways link these two proteins together.
Butt, Aiza
core
Polycomb proteins and breast cancer
, 2013 In the Western world, breast cancer is the most frequent malignancy in women and still the leading cause of cancer related deaths, therefore, a better understanding of the disease is needed.
Fedele, Vita
core
The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics
Clinical Genetics, EarlyView.The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree +18 more
wiley +1 more source