Results 141 to 150 of about 73,095 (214)

The Landscape of BRCA1-Associated Post-Translational Modifications. [PDF]

Cell Biol Int
Waduge NH, Xiao J, Davis GM.
europepmc   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, Volume 38, Issue 51, 11 September 2026.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

Advanced Science, Volume 13, Issue 53, 24 September 2026.
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li, Minghua Xiang, Qiuyang Xu, Jiahao Liu, Xiaofei Jiao, Wei Mu, Xiaoying Lv, Kangjia Tao, Yu Xu, Dongchen Zhou, Wenjian Gong, Danmei Yan, Yixin Hu, Sen Xu, Bingbing Zhao, Jundong Li, Yongkang Gai, Guang Hu, Li Zhu, Qinglei Gao, Yong Fang   +20 more
wiley   +1 more source

Germline <i>BRCA1</i> pathogenic variants and T cell dysfunction. [PDF]

Immunooncol Technol
Kay J, Harris MA, Lara Gonzalez LE, van Geelen CT, Clarke KA, Virassamy B, Caramia F, Pang JM, O'Malley MMR, Hun ML, Salgado R, Thorne H, Visvader J, Neeson PJ, Darcy PK, Loi S.   +15 more
europepmc   +1 more source

Nucleases and Their Inhibitors: Exploring Biological Roles, Industrial Applications, and Challenges in Heterologous Expression

Biotechnology Journal, Volume 21, Issue 9, September 2026.
Graphical Abstract and Lay Summary Intracellular nucleases, depicted as blue circles in a nucleosome, hydrolyze phosphodiester bonds, repair damaged DNA using DNA base excision repair (BER), mismatch repair (MMR), and homologous recombination (HR), and are involved in DNA replication.
Wian Vermeulen, Anton Du Preez van Staden, Leon M. T. Dicks   +2 more
wiley   +1 more source

GSK3β and Plk1 sequentially phosphorylate ATP-citrate lyase to promote homologous recombination. [PDF]

Sci Adv
Zhou S, Zhou X, Chen Q, Yuan X, Zhu S, Huang J, Wang F, Yan H.   +7 more
europepmc   +1 more source

PD‐L1 in Ovarian Cancer: Immune Evasion, Tumor‐Intrinsic Signaling, and Chemoresistance

Cancer Medicine, Volume 15, Issue 9, September 2026.
The “Dual Shield” model of PD‐L1 in ovarian cancer. On the outside, PD‐L1 engages PD‐1 to inactivate T cells and drive immune evasion (immune shield). Inside the tumor cell, PD‐L1 activates AKT–mTOR, enhances DNA repair, rewires metabolism, supports autophagy, and enforces stemness programs—collectively creating a chemoresistance shield.
Zhiyang Xu, Xiaohui Lv, Yunping Wang, Yanjie Ren   +3 more
wiley   +1 more source

Tumor cell intrinsic dsRNA innate immune response triggered by PARP inhibitor is compromised in BRCA1-deficient breast cancer by repressing IRF3. [PDF]

Protein Cell
Zhang C, Zhou JB, Lei JH, Ang IL, Miao K, Xu X, Poon TCW, Cheung E, Deng CX.   +8 more
europepmc   +1 more source

Histone Post‐Translational Modifications Regulating Ferroptosis: The Molecular Mechanisms and Disease Associations

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Ferroptosis is a form of programmed cell death characterized by iron‐dependent phospholipid peroxidation and is implicated in a wide range of human diseases. Emerging evidence highlights the critical role of epigenetic regulation in this process.
Xiaoqian Tang, Haodang Luo, Siqi Gao, Xiaocheng Liu, Qing Sun, Yanhua Zeng   +5 more
wiley   +1 more source

XYL-1 and Olaparib Synergistically Inhibit the Growth of Pancreatic Cancer by Suppressing the SCD1/BRCA1 Signaling Pathway. [PDF]

Molecules
Yang Y, Huang L, Du Y, Zhu Q, Dai L, Qian B.   +5 more
europepmc   +1 more source