Results 161 to 170 of about 73,095 (214)

Targeting the GPR183/EBI2‒oxysterol axis in tuberculosis: Immunometabolic regulation and prospects for host‐directed therapy

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
GPR183/EBI2 links oxysterol metabolism with immune‐cell positioning and macrophage function in tuberculosis. The 7α,25‐OHC‐GPR183 axis regulates macrophage trafficking, autophagy and type I interferon responses. GPR183 represents a potential immunometabolic target for host‐directed therapy against tuberculosis..
Junfei Wang, Yingnan Zhou, Xunming Ji, Haiping Zhao, Lingjun Zhan   +4 more
wiley   +1 more source

The Clinical Application of Refined Risk Estimates Study in BRCA1 and BRCA2 Pathogenic Variant Carriers: A Randomized Controlled Trial. [PDF]

Cancer Prev Res (Phila)
Senter L, Hovick S, Notestine R, Norden L, Benny N, Phillips S, Willoughby A, Pyatt R, Agnese D, Mak JS, DePersia A, Colonna SV, Maxwell WF, Kohlmann W, Spaeth EL, Gordon O, Thull D, Brock GN, Webb A, Smith RM, Toland AE.   +20 more
europepmc   +1 more source

Spatiotemporal immune heterogeneity and precision immunotherapy for ovarian cancer

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Graphical Highlights Spatiotemporal immune heterogeneity shapes distinct and evolving immune ecosystems in ovarian cancer. Multimodal biomarkers enable biologically informed patient stratification beyond static single‐marker approaches. Precision immunotherapy should match dominant immune barriers across lesions and treatment stages.
Xinfeng Yang, Yida Wang, Haiyue You, Jingyi Gao, Yangkun Feng, Feng Zhang, Yan Zhang, Bing Zhang, Shaojie Zhao, Yanfang Gu   +9 more
wiley   +1 more source

Systemic immune activation in hereditary cancer predisposition syndromes: a cross-sectional study. [PDF]

BMC Med
Kelemen I, Horti-Oravecz K, Bozsik A, Pócza T, Papp J, Likó I, Neuperger P, Balogh F, Kemény Á, Nagy P, Vereczki V, Pósa SP, Pongor LS, Kövesdi D, Butz H, Patócs A, Szebeni GJ, Grolmusz VK.   +17 more
europepmc   +1 more source

The Diagnostic Value of Immunohistochemistry and Biomarkers in the Diagnosis of Mesothelioma in Pleural/Peritoneal Effusions

Diagnostic Cytopathology, Volume 54, Issue 9, Page 631-636, September 2026.
ABSTRACT Background Mesothelioma is a rare tumor that arises from the serosal cells lining the serous cavities, most commonly the pleura followed by the peritoneum. Presenting symptoms include pleuritic pain and bloody effusions that recur. Although cytologic analysis cannot determine the mesothelial subtype or in situ from invasive disease, the ...
Suzanne M. Selvaggi
wiley   +1 more source

BRCA1-RAD51 homologous DNA repair pathway promotes HIV-1 reverse transcription. [PDF]

Sci Adv
Lapaillerie D, Tumiotto C, Scoca V, Figueiredo S, Maisch M, Bertinetti C, Mougel M, Fleury F, Lesbats P, Delelis O, Dutrieux J, Di Nunzio F, Parissi V.   +12 more
europepmc   +1 more source

Cinnamaldehyde From Cinnamon as a Food‐Derived Bioactive: Phytochemistry, Anticancer Mechanisms, Bioavailability, Nanoformulation and Safety

Food Frontiers, Volume 7, Issue 5, September 2026.
Cinnamaldehyde derived from Cinnamomum species exerts multitarget anticancer effects by promoting oxidative stress, mitochondrial dysfunction, apoptosis, cell‐cycle arrest, autophagy, and epigenetic changes, and by suppressing mitogen‐activated protein kinase (MAPK), phosphoinositide 3‐kinase/protein kinase B/mechanistic target of rapamycin (PI3K/Akt ...
Gervason Moriasi, Sally Kamau, Gulnaz Seitimova, Shynar Zhumagaliyeva, Javad Sharifi‐Rad, William N. Setzer, Daniela Calina   +6 more
wiley   +1 more source

Assessing the Clinical Relevance of <i>BRCA1</i> RING Domain Variants of Uncertain Significance. [PDF]

Curr Oncol
Martin MD, Torretto GC, Islam K, Archer NE, Feilotter HE, Davey SK.   +5 more
europepmc   +1 more source

Biological Activities, Medicinal Uses, and Nutritional Effects of Terminalia arjuna (Roxb. ex DC.) Wight & Arn.: Phytochemical Insights and Therapeutic Benefits in Ulcerative Colitis Management—A Detailed Review

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
This graphical abstract highlights the versatile therapeutic potential and food applications of Terminalia arjuna, centering on its broad health‐promoting bioactivities. Key mechanisms described include adaptogenic, cardioprotective, gastroprotective, wound‐healing, and anti‐inflammatory effects mediated through Nrf2 and NF‐κB signaling pathways ...
Rameen Naeem, Muhammad Tauseef Sultan, Muhammad Usman Khalid, Muhammad Maaz, Ayman Furqan, Laiba Tanvir, Fabiano Travaglia, Matteo Bordiga, Mutjardah Zarrish   +8 more
wiley   +1 more source

Differential roles of BRCA1 and BRCA2 in the DNA damage response revealed by isogenic V79 mutant cell lines. [PDF]

Mutagenesis
Chailapakul P, Maeda J, Miura T, Kato TA.   +3 more
europepmc   +1 more source