Results 171 to 180 of about 74,972 (273)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, Volume 16, Issue 7, Page 1370-1386, July 2026.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

STATUS METILASI GEN BRCA1 GEN BRCA2 EKSPRESI PROTEIN BRCA1 PROTEIN BRCA2 HUBUNGANNYA DENGAN TERJADINYA TUMOR EPITELIAL OVARIUM DERAJAD DIFERENSIASI JENIS HISTOPATOLOGI STADIUM DAN SURVIVAL PENDERITA KANKER EPITELIAL OVARIUM

, 2013
Cancer initiation and progression are controlled by genetic and epigenetic events. Cancer develops through multistep process in which the genomes of cancer cells mutate in several groups of genes such as proto-oncogen, tumor suppresor genes and other ...
, Prof. dr. H. Djaswadi Dasuki SpOG(K),, , Heru Pradjatmo, dr.,Sp.OG(K).,M.Kes.   +1 more
core  

Semi-Quantitative Evaluation of BRCA1 Protein in Breast Tumors Using Anti-BRCA1 Antibodies: Clinical Implications. [PDF]

Int J Mol Sci
Anton SC, Nedelcu AH, Ianole V, Anton C, Danciu M, Morariu ID, Lupu A, Dascalescu G, Lupu VV, Knieling A, Nicolaiciuc D, Ciobica A, Chivasuta EA, Tirnovanu M, Dondiuc I, Ilea C, Grigore M, Anton E.   +17 more
europepmc   +1 more source

BRCA1-Associated Protein 1 Testing in Cancer [PDF]

Journal of Thoracic Oncology, 2016
openaire   +2 more sources

PKMYT1 in Cancer: Beyond Cell Cycle Checkpoints to Context‐Dependent Therapeutic Vulnerability

Genes, Chromosomes and Cancer, Volume 65, Issue 7, July 2026.
ABSTRACT PKMYT1 has emerged as a promising therapeutic target distinguished by its tumor‐selective expression and essential role in replication stress management. Unlike WEE1, PKMYT1 is dispensable in normal cell cycles but critical for cancer cells coping with DNA damage, establishing a broad therapeutic window.
Lingxi Li, Binfan He, Mengmeng Hao, Ye Liu, Shunxin Song, Rongzhang He   +5 more
wiley   +1 more source

Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple-negative breast cancer cells. [PDF]

Cancer Sci
Choi E, Jeon KH, Lee H, Mun GI, Kim JA, Shin JH, Kwon Y, Na Y, Lee YS.   +8 more
europepmc   +1 more source

PVT1 lincRNA signals an androgen‐dependent transcriptional activation program of oncogenes in prostate cancer cells

International Journal of Cancer, Volume 159, Issue 1, Page 144-158, 1 July 2026.
What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho, Fabio Nunes de Mello, Ana Carolina Tahira, Gabriel Nakanishi Fortes, Agatha Fischer‐Carvalho, Pedro Jardim Poli, Murilo Sena Amaral, Sergio Verjovski‐Almeida   +7 more
wiley   +1 more source

BRCA1 Protein Expression in Epithelial Ovarian Cancer and Associated Clinicopathological Factors in Uganda. [PDF]

Obstet Gynecol Int
Okecha T, Abila DB, Nabbale DL, Katongole F, Yahaya JJ, Lukande R, Kalungi S, Nalwoga H.   +7 more
europepmc   +1 more source

Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy

MedComm, Volume 7, Issue 7, July 2026.
Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu, Zhixing Hao, Lili Li, Huiying Liu, Chenghui Yang, Zhen Wang   +5 more
wiley   +1 more source

BRCA1 and BRCA2 proteins are expressed in milk fat globules [PDF]

International Journal of Cancer, 1999
D J, Bernard-Gallon, P, Dechelotte, P G, Rio, Y J, Bignon   +3 more
openaire   +2 more sources