Results 191 to 200 of about 111,862 (289)

SERBP1 is required for efficient HR repair and cisplatin chemoresistance in lung adenocarcinoma. [PDF]

Cell Death Discov
Xie Y, Chen Q, Tang N, Zeng Y, Zhao J, Yang Y, Li C, Li J, Zhu J, Huang JA, Liu Z.   +10 more
europepmc   +1 more source

At the Right Time: Temporal Precision in Personalised Medicine

Sociology of Health &Illness, Volume 48, Issue 4, May 2026.
ABSTRACT Personalised medicine was initially heralded as delivering ‘the right drug to the right patient at the right time’. Although molecular precision has dominated recent developments, the temporal dimension has remained underexplored. This paper examines how temporal precision is emerging as a defining feature of next‐generation precision medicine,
Dominik Hofmann, Elena Esposito
wiley   +1 more source

From mutation to treatment: The dual role of BRCA1 and BRCA2 in gynecological malignancy development and management a systematic review. [PDF]

Biochem Biophys Rep
Georgy DM, Sedeek HN, Abaza NE, Eldeeb SEK, Khamis SM, Elgamil MR, Magar RW.   +6 more
europepmc   +1 more source

Copy Number Amplification and c‐Myc Transcriptional Activation‐Mediated RNA‐Binding Protein MEX3A Promotes EGFR‐TKI Resistance in Non–Small‐Cell Lung Cancer

Thoracic Cancer, Volume 17, Issue 9, May 2026.
MEX3A, a pivotal RNA‐binding protein (RBP), which is activated by copy number amplification at the genomic level and regulated by the transcription factor c‐Myc at the transcriptional level, functions as a potential therapeutic target for overcoming TKI resistance in NSCLC. ABSTRACT Objective To investigate the functional role and activation mechanisms
Shi Xiling, Du Lin, Dai Jiali, Zhang Chen, Huang Ruohan, Zhang Chang, Guo Renhua, Li Jun   +7 more
wiley   +1 more source

BARD1 recognizes pre-rRNA for DNA damage repair and rRNA biogenesis. [PDF]

J Biol Chem
Huang H, Wu D, Yu X.
europepmc   +1 more source

Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons

Aging Cell, Volume 25, Issue 5, May 2026.
Neurons expressing APOE2 were more resistant to endogenous DNA damage, activated transcriptional signaling pathways associated with DNA repair, and were resilient to stress‐induced DNA damage and cellular senescence. In contrast, APOE4 neurons exhibited elevated expression of rRNA repetitive elements and were prone to becoming senescent.
Cristian Gerónimo‐Olvera, Stephen M. Scheeler, Carlos Galicia Aguirre, Genesis Vega‐Hormazabal, Daniela Garcia, Long Wu, Natalia Murad, Kevin Schneider, Kenneth A. Wilson, Nikola T. Markov, Sicheng Song, Jesse Simons, Akos A. Gerencser, Emily Parlan, Sean D. Mooney, Eric Verdin, Judith Campisi, Tara E. Tracy, David Furman, Simon Melov, Lisa M. Ellerby   +20 more
wiley   +1 more source

Cryptic redundancy between PAR1b and PAR1a, two members of the PAR1 kinase family, in the survival of PAR1b-knockout mice. [PDF]

Sci Rep
Murata-Kamiya N, Del Valle Lazarte AA, Kikuchi I, Hatakeyama M.   +3 more
europepmc   +1 more source

Aging‐Driven Immunosuppression: The Role of Tregs in the Ovarian Tumor Microenvironment

Aging Cell, Volume 25, Issue 5, May 2026.
In the aged ovarian TME, cancer cells exhibit increased succinate production. Elevated extracellular succinate activates the SUCNR1 receptor on Tregs, promoting their recruitment and contributing to an immunosuppressive environment. This leads to diminished anti‐tumor T cell responses and reduced survival.
Mary P. Udumula, Anjaly KM, Faraz Rashid, Mohammad Nematullah, Harshit Singh, Tanya Bhardwaj, Miriana Hijaz, Shailendra Giri, Eduardo N. Chini, Heather M. Gibson, Ramandeep Rattan   +10 more
wiley   +1 more source

Resistance to neoadjuvant talazoparib in triple-negative breast cancer by BRN2-induced ATR/STAT3 pathways or SHLD2 subclone expansion. [PDF]

Proc Natl Acad Sci U S A
Abdulkareem NM, Jiang Y, Qi Y, Liu X, Zhang X, Cai S, Shao J, Jeter-Jones S, Rinkenbaugh AL, Cheng CC, Hancock F, Schwartz J, Litton JK, Chang JT, Piwnica-Worms H.   +14 more
europepmc   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, Volume 183, Issue 9, Page 1727-1746, May 2026.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source