Results 181 to 190 of about 73,095 (214)

Mitochondria as the Hub of Apoptosis: A Comprehensive Insight From Mitochondria to Interactions With Other Organelles

MedComm, Volume 7, Issue 9, September 2026.
Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan, Jinming Zhao, Rong Wang, Yue Shi, Zaozao Chen, Yixuan Ma, Na Li, Wenqing Duan, Duo Lin, Chunxiang Zhang   +9 more
wiley   +1 more source

Network toxicology and molecular docking identify BRCA1 as a functional target of the dietary carcinogen PhIP in colorectal cancer. [PDF]

Discov Oncol
Deng Y, Wang C, Hu Y, Cao H.
europepmc   +1 more source

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

MedComm, Volume 7, Issue 9, September 2026.
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

High‐Content CRISPR Screening: Methods and Applications

MedComm, Volume 7, Issue 9, September 2026.
High‐content CRISPR screening represents a paradigm shift in functional genomics, moving beyond traditional survival‐based readouts to enable multidimensional mapping of genotype–phenotype relationships. This review systematically outlines the methodological evolution of this approach, detailing advances in perturbation modalities, delivery systems ...
Yike Zhang, Yimeng Zhang, Xudong Tang, Xinyu Deng, Yitian Zhou, Yanfeng Wu, Jianhua Luo   +6 more
wiley   +1 more source

Extended Germline Profiling of Cancer Predisposition and Homologous Recombination Repair Genes in 275 Russian Patients with Triple-Negative Breast Cancer. [PDF]

Biomedicines
Shatalov PA, Bukaeva AA, Veselovsky EM, Traspov AA, Revkova MA, Mishakova PV, Kirillova EA, Raygorodskaya MP, Bagdasarova DV, Leukhina IA, Shinkarkina AP, Murzaeva AV, Mechenici YA, Kaprin AD, Shegai PV.   +14 more
europepmc   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

BRCA1 deficiency induces NFκB-dependent type-I interferon signaling in fallopian tube epithelial cells. [PDF]

Neoplasia
Madaan V, Kollara A, Spaner D, Brown TJ.
europepmc   +1 more source

Cell‐Type‐Resolved Proteomics Reveals Distinct Immune and Metabolic Programs Between Primary and Recurrent Ascites in HGSOC

PROTEOMICS – Clinical Applications, Volume 20, Issue 5, September 2026.
ABSTRACT High‐grade serous ovarian carcinoma (HGSOC) frequently recurs after platinum–taxane therapy, yet recurrence‐associated changes within ascites remain unclear. We performed cell‐type‐resolved quantitative proteomics on paired ascites samples collected at primary diagnosis and at disease recurrence from three HGSOC patients, profiling unsorted ...
Bo Ren, Kenneth Weke, Darryl Hardie, Sarah MacPherson, Javier A Alfaro, Julian J Lum, David R Goodlett   +6 more
wiley   +1 more source

Monoallelic BRCA1/2 variants in pediatric, adolescent, and young adult patients with central nervous system tumors. [PDF]

ESMO Open
Cipri S, Agolini E, Baldo GD, Cacchione A, Megaro G, Rossi S, Barresi S, Carai A, Colafati GS, Boccuto L, Mastronuzzi A.   +10 more
europepmc   +1 more source

Prevalence of Helicobacter pylori Exposure and Risk Factors Among BRCA1 and BRCA2 Carriers. [PDF]

Int J Cancer
Buckley KH, Zhu Y, Dinh K, Hausler R, Gala R, Spiegel SR, Delgado R, Clay DG, Kelly GM, Brower J, Domchek SM, Maxwell KN, Katona BW.   +12 more
europepmc   +1 more source