Results 211 to 220 of about 111,862 (289)

Regulatory BC200 RNA promotes breast carcinogenesis by repressing BRCA1 gene expression. [PDF]

iScience
Berardi V, Muslimov IA, Sun D, Militello G, Premsrirut P, Tiedge H.   +5 more
europepmc   +1 more source

Molecular pathology of phyllodes tumours of the breast—much more than MED12

Histopathology, Volume 88, Issue 6, Page 1115-1125, May 2026.
Phyllodes tumours can develop from fibroadenomas bearing MED12 variants by the development of pTERT alterations (“MED12 pathway”) or de novo (“MED12 independent pathway”). Grade progression is associated with increasing genetic complexity including cancer driver gene aberrations. Molecular alterations can be useful in assigning grade and distinguishing
Jia‐Min B Pang, Kylie L Gorringe, Puay Hoon Tan, Stephen B Fox   +3 more
wiley   +1 more source

Mutational profiles of spontaneous and radiation-related mammary carcinomas in a rat model of Brca1 haploinsufficiency. [PDF]

Sci Rep
Nakamura Y, Daino K, Ishikawa A, Kakinuma S, Nishimura-Yano Y, Nagata K, Takabatake M, Nishimura M, Mashimo T, Inoue K, Imaoka T.   +10 more
europepmc   +1 more source

Production of recombinant human BRCA1 encoded proteins in E.coli

, 1997
ÖZET insan BRCA1 Rekombinant Proteininin E.co/î'de Üretilmesi Berna S. Özçelik Yüksek Lisans Tezi, Molekûler Biyoloji ve Genetik Bölümü Tez yöneticisi: Prof. Dr. Mehmet Öztürk Ağustos 1997, 137 sayfa BRCA1 geni, ailesel, genç yaşta baş gösteren meme kanseri ile ilişkisi olduğu saptanan ilk gendir ve onyedinci kromozomda yer almaktadır.
openaire   +2 more sources

In Vitro Evaluation of PARP1 Inhibitor Olaparib‐Cyanine Dye Conjugate for the Treatment of Glioblastoma

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Inhibition of DNA damage repair is a common mechanism to induce cancer cell death and, therefore, to treat cancers such as breast, prostate and ovarian cancer. This approach, although very attractive, has not been feasible for treating brain tumours due to the stringent structural features necessary for pharmaceutical agents to cross the blood–brain ...
Carina Dumo, Faheem, Peter J. Choi, Nicholas J. Pederson, Yuge Liu, Mike Dragunow, Thomas I‐H. Park, Katharine L. Diehl, Jiney Jose   +8 more
wiley   +1 more source

Cancer metabolism in radiation sensitization - complementary roles of O-GlcNAc transferase and PARP1. [PDF]

J Cell Sci
Efimova E, Liu Y, Averbek S, Choi S, Ha S, Ricco N, Lomeli I, Viguls E, Kim WY, Kron SJ.   +9 more
europepmc   +1 more source

A phase 1 study of ASTX727 plus talazoparib in patients with triple‐negative or hormone resistant/HER2‐negative metastatic breast cancer

Cancer, Volume 132, Issue 8, 15 April 2026.
Abstract Background Poly(adenosine diphosphate ribose) polymerase (PARP) is recruited to DNA damage sites along with epigenetic factors such as DNA methyltransferase 1 (DNMT1). Inhibitors of DNMT modulate reactive oxygen species (ROS)‐cyclic adenosine monophosphate (cAMP)/Protein Kinase A signaling and induce a “BRCAness phenotype” that further ...
Kathy D. Miller, Alexandra Thomas, Sandra Althouse, Yong Zang, Erin Conder, Ryan Burgos, Bryan P. Schneider, Tarah Ballinger, Emily Douglas, Katherine Ansley, H. Josh Jang, Woonbok Chung, Jean‐Pierre Issa, Kenneth P. Nephew, Feyruz V. Rassool   +14 more
wiley   +1 more source

Epacadostat and Olaparib Synergistically Inhibit the Growth of BRCA-Proficient Triple-Negative Breast Cancer by Suppressing the Expression of BRCA1 and RAD51. [PDF]

Molecules
Huang L, Yang Y, Duan D, Dai L, Zhai B, Qian B.   +5 more
europepmc   +1 more source

Risk of Breast and Ovarian Cancer After Prophylactic Mastectomy and Salpingo-Oophorectomy in BRCA1/2 Germline Variant Carriers: A Retrospective Cohort Study From a Single German Center. [PDF]

Cancer Med
Mendes S, Yahiaoui-Doktor M, Fallenberg EM, Kiechle M, Grill S.   +4 more
europepmc   +1 more source

Integrating breast tumour homologous recombination deficiency status to aid germline BRCA1 and BRCA2 variant classification. [PDF]

EBioMedicine
Fortuno C, Zhang J, Koufariotis LT, Hollway G, Wood S, Pearson JV, Simpson PT, Lakhani SR, McCart Reed AE, Thorne H, Mann GB, Skandarajah AR, Devereux L, Zhao Q, De Silva DL, Lindeman GJ, Waring P, James PA, Campbell I, Spurdle AB, Waddell N.   +20 more
europepmc   +1 more source