Results 151 to 160 of about 74,972 (273)

BRCA1 Protein Variant [PDF]

, 2020
openaire   +1 more source

Unravelling the phylogeny of armadillos and their kin (Mammalia, Xenarthra, Cingulata) combining morphological, molecular, and stratigraphic data

Cladistics, EarlyView.
Abstract Cingulata, a major lineage of Xenarthra, comprises extinct and extant armoured placental mammals that diversified throughout the Cenozoic. Despite extensive study, phylogenetic hypotheses based on morphological and molecular data remain incongruent, and no total evidence analysis has been conducted. Here, we integrate the largest morphological
Daniel M. Casali, Mariela C. Castro, Martin R. Ciancio, Timothy J. Gaudin, Jeremy L. Bramblett, Alberto Boscaini, Fernando A. Perini, Max C. Langer   +7 more
wiley   +1 more source

BRCA1 and Smad3 association.

, 2013
(A) HA-BRCA1 interacts with Flag-Smad3 in HEK293T cells. 0.5 µg of wild type HA-BRCA1 and 0.50 µg of Flag-Smad3 plasmids were co-transfected into HEK293T cells, as indicated.
Hava Karsenty Avraham (32550), Masayuki Sekine (74314), Huchun Li (370357), Seyha Seng (74313), Shalom Avraham (32549)   +4 more
core   +1 more source

Prevalence of BRCA1 gene mutations in female breast cancer patients in Mazandaran Province, Northern Iran

Egyptian Journal of Medical Human Genetics
Background Breast cancer is one of the major global health concerns, and the investigation of mutations in the BRCA1 gene is essential for prevention and treatment. Carriers of pathogenic BRCA1 gene variants face an increased risk of breast cancer during
Masoumeh Jangjou, Majid Alipour, Ramin Mofarrah, Soroush Alipour   +3 more
doaj   +1 more source

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

Cell Proliferation, EarlyView.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu, Shifei Song, Ruilin Wang, Ni An, Jinmei Diao, Yuguo Chen, Juan Liu, Guoyue Lv   +7 more
wiley   +1 more source

CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response

, 2007
The product of the breast cancer-1 gene, BRCA1, plays a crucial part in the DNA damage response through its interactions with many proteins, including BACH1, CtIP and RAP80.
Junjie Chen, Hongtae Kim, Jun Huang, Kim, Hongtae, Chen, Junjie, Huang, Jun   +5 more
core   +1 more source

Identification and functional analysis of novel BRCA1 transcripts, including mouse Brca1-Iris and human pseudo-BRCA1

, 2010
Recent characterization of the mammalian transcriptome has confirmed its predicted complexity, with many loci encoding multiple splice variants and pseudogenes.
Smart, C. E., Pettigrew, C. A., Saunus, J. M., French, J. D., Edwards, S. L., Spurdle, A. B., Lundstrom, H. T., Rothnagel, J. A., Wiesner, C., Sauer, A. V., Brown, M. A.   +10 more
core   +1 more source

BRCA1 Interacts with Poly(A)-binding Protein [PDF]

Journal of Biological Chemistry, 2006
Eva Dizin, Céline Gressier, Clémence Magnard, Hind Ray, Didier Décimo, Théophile Ohlmann, Nicole Dalla Venezia   +6 more
openaire   +1 more source

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, EarlyView.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source