Results 271 to 280 of about 104,745 (290)
Some of the next articles are maybe not open access.
Current Problems in Cancer, 2014
A hereditary breast cancer syndrome can present in a variety of ways ranging from an index case of early-onset breast cancer to an incidental finding during an endoscopy or a dermatological examination. A comprehensive review of the patient’s personal and family history is essential to accurately assess the risk for a hereditary cancer syndrome ...
Kimberly, King-Spohn, Robert, Pilarski
openaire +2 more sources
A hereditary breast cancer syndrome can present in a variety of ways ranging from an index case of early-onset breast cancer to an incidental finding during an endoscopy or a dermatological examination. A comprehensive review of the patient’s personal and family history is essential to accurately assess the risk for a hereditary cancer syndrome ...
Kimberly, King-Spohn, Robert, Pilarski
openaire +2 more sources
International Journal of Gastrointestinal Cancer, 2002
Many factors, including a family history of cancer, have been implicated in the development of pancreatic cancer. Among these factors, germline BRCA2 mutations have been clearly associated with the development of this disease, while mutations in BRCA1 appear to have a limited role. Patients with pancreatic cancer and germline BRCA2 mutations tend to be
Ali, Naderi, Fergus J, Couch
openaire +2 more sources
Many factors, including a family history of cancer, have been implicated in the development of pancreatic cancer. Among these factors, germline BRCA2 mutations have been clearly associated with the development of this disease, while mutations in BRCA1 appear to have a limited role. Patients with pancreatic cancer and germline BRCA2 mutations tend to be
Ali, Naderi, Fergus J, Couch
openaire +2 more sources
Tetraploidy in BRCA2 breast tumours
European Journal of Cancer, 2012Tetraploidy and aneuploidy can be caused by cell division errors and are frequently observed in many human carcinomas. We have recently reported delayed cytokinesis in primary human fibroblasts from BRCA2 mutation carriers, implying a function for the BRCA2 tumour suppressor in completion of cell division.
Asta Bjork, Jonsdottir +5 more
openaire +2 more sources
Brca2 hereditary breast cancer pathophenotype
Breast Cancer Research and Treatment, 1997Four BRCA2 hereditary breast cancer (HBC) families manifested significant excesses of ‘tubular-lobular group’ (TLG) invasive carcinomas and lobular carcinoma in situ/atypical lobular hyperplasia in comparison to BRCA1-HBC cases.
J N, Marcus +7 more
openaire +2 more sources
Structural insights into BRCA2 function
Current Opinion in Structural Biology, 2003BRCA2 is a tumor suppressor directly implicated in familial breast cancer. Extensive genetic and biochemical characterization has shown that BRCA2 is involved in the maintenance of chromosomal stability and that it has an important role in recombination-mediated double-strand DNA break repair.
openaire +2 more sources
2019
Aim: the results of clinical, clinico-genealogical and molecular-genetic investigation of patients from family with tumor aggregation in two generations were analyzed. Object and methods: the data on proband, her parents and sisters were included to the analyses.
openaire +1 more source
Aim: the results of clinical, clinico-genealogical and molecular-genetic investigation of patients from family with tumor aggregation in two generations were analyzed. Object and methods: the data on proband, her parents and sisters were included to the analyses.
openaire +1 more source