Results 31 to 40 of about 982,593 (292)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
TIME-DEPENDENT DIELECTRIC BREAKDOWN CHARACTERIZATION OF A HIGH VOLTAGE CAPACITOR [PDF]
, 2011 NXP Semiconductors Business Unit (BU) Automotive is a corporate organization that provides design technology for the automotive product creation process.
Sasongko, Brecia Nurastu
core +1 more source
Optimized Design of 1 700 V IGBT Field Limiting Ring and Field Plate Termination
机车电传动, 2021 The breakdown voltage is an important parameter for IGBT, and the breakdown voltage of the device is mainly related to the termination structure, so the research on the termination structure has always attracted attention.
Rongbin ZHOU +6 more
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Applied Sciences, 2023 With 45# transformer oil as the base fluid, different concentrations of TiO2 nanomodified transformer oil were prepared via the thermal oscillation method.
Chunxu Qin +5 more
doaj +1 more source
XXI century. Technosphere Safety, 2020 The article deals with one of the complex issues that affect the protective properties of a person when exposed to electric current, namely, the voltage that causes the skin breakdown. The value of voltage that causes the skin breakdown defines the concept of low voltage.
openaire +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Energies, 2022 Space charge accumulation in polypropylene (PP) affect the dielectric properties and breakdown strength of the material. The pre-injected charge in PP under the action of different polarity voltage is quantitatively characterized, and the effects of the ...
Zhaoliang Xing +6 more
doaj +1 more source