Results 71 to 80 of about 1,072,283 (301)

Research on Rock-Breaking Characteristics of Cutters and Matching of Cutter Spacing and Penetration for Tunnel Boring Machine

open access: yesBuildings
Tunnel boring machine (TBM) tunnel construction in composite strata relies heavily on understanding the rock-breaking characteristics of TBM cutters and optimizing cutter spacing and penetration.
Huipeng Zhang   +3 more
doaj   +1 more source

Influences of Microwave Irradiation on Rock-Breaking Efficiency of a Reduced-Scale TBM Cutter

open access: yesApplied Sciences, 2023
To explore the influences of microwave irradiation on the rock-breaking efficiency of tunnel boring machine (TBM) cutters, a multimode cavity with a microwave power of 2100 W was used to conduct microwave irradiation tests on Chifeng basalt for different
Gaoming Lu   +4 more
doaj   +1 more source

The Nucleon-Mass Difference in Chiral Perturbation Theory and Nuclear Forces [PDF]

open access: yes, 2004
A new method is developed for treating the effect of the neutron-proton mass difference in isospin-violating nuclear forces. Previous treatments utilized an awkward subtraction scheme to generate these forces.
A. L. Bondarev   +13 more
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Symmetry breaking and singularity structure in Bose-Einstein condensates [PDF]

open access: yes, 2012
We determine the trajectories of vortex singularities that arise after a single vortex is broken by a discretely symmetric impulse in the context of Bose-Einstein condensates in a harmonic trap.
Carr, Lincoln D.   +3 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

A study of global monopole in Lyra geometry

open access: yes, 2007
A class of exact static solution around a global monopole resulting from the breaking of a global S0(3) symmetry is obtained in the context of Lyra geometry. Our solution is shown to possess an interesting feature like wormholes space-time.
F. RAHAMAN   +4 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

On the use of the proximity force approximation for deriving limits to short-range gravitational-like interactions from sphere-plane Casimir force experiments [PDF]

open access: yes, 2009
We discuss the role of the proximity force approximation in deriving limits to the existence of Yukawian forces - predicted in the submillimeter range by many unification models - from Casimir force experiments using the sphere-plane geometry.
Dalvit, Diego A. R., Onofrio, Roberto
core   +3 more sources

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

open access: yesFEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman   +4 more
wiley   +1 more source

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