Huntingtin-associated protein 1 interacts with breakpoint cluster region protein to regulate neuronal differentiation. [PDF]
PLoS ONE, 2015 Alterations in microtubule-dependent trafficking and certain signaling pathways in neuronal cells represent critical pathogenesis in neurodegenerative diseases. Huntingtin (Htt)-associated protein-1 (Hap1) is a brain-enriched protein and plays a key role
Pai-Tsang Huang +8 more
doaj +6 more sources
Comparative Expression Analysis of Breakpoint Cluster Region-Abelson Oncogene in Leukemia Patients. [PDF]
ACS Omega, 2023 Leukemia is a proliferative disorder of myeloid and lymphoid cells that may lead to death. Different types of leukemia have been reported, and several genetic and environmental factors are involved in their development. The Philadelphia chromosome causes the most common mutation known as breakpoint cluster region-Abelson oncogene (BCR-ABL1), which ...
Arshad F +9 more
europepmc +4 more sources
Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation [PDF]
Haematologica, 2020 Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor ...
Malalage N. Peiris +4 more
doaj +6 more sources
Mutations in the breakpoint cluster region-Abelson murine leukemia 1 gene in Brazilian patients with chronic myeloid leukemia [PDF]
Hematology, Transfusion and Cell Therapy, 2018 Introduction: Mutations in the breakpoint cluster region-Abelson murine leukemia 1 gene are the leading cause of resistance to treatment with tyrosine kinase inhibitors in chronic myeloid leukemia patients.
Heloísa Zorzi Costa +5 more
doaj +3 more sources
BCR (Breakpoint cluster region) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on BCR (breakpoint cluster region), with data on DNA, on the protein encoded, and where the gene is implicated.
Ali G. Turhan
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PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle. [PDF]
PLoS ONE, 2015 Scavenger receptor class B, type I (SR-BI) and its adaptor protein PDZK1 mediate responses to HDL cholesterol in endothelium. Whether the receptor-adaptor protein tandem serves functions in other vascular cell types is unknown.
Wan Ru Lee +10 more
doaj +2 more sources
Nucleolytic Cleavage of the Mixed Lineage Leukemia Breakpoint Cluster Region during Apoptosis [PDF]
Journal of Biological Chemistry, 2001 VP-16 (etoposide) has recently been shown to induce topoisomerase II (TOP2)-mediated DNA cleavage within the mixed lineage leukemia (MLL) breakpoint cluster region (bcr), suggesting a role of TOP2 in MLL gene rearrangement. In our current studies, we have compared the induction of DNA cleavage within the MLL bcr in different cell lines after treatment ...
Sai-Peng Sim, Leroy F. Liu
openalex +4 more sources
Aberrant methylation of the major breakpoint cluster region in chronic myeloid leukemia [PDF]
Blood, 1996 Isolated hypomethylated sites exist in the major breakpoint cluster region (M-bcr) where most Philadelphia chromosome (Ph) breakpoints are located. Twenty of 50 (40%) chronic myeloid leukemia (CML) patients were found to have aberrant hypermethylation of these sites on the rearranged M-bcr when compared with control marrows.
CE Litz, J A Vos, CM Copenhaver
openalex +3 more sources
Mechanistic study of TFE3 breakage in TFE3-rearranged renal cell carcinoma: the perspective of non-canonical DNA structures and their stability [PDF]
Frontiers in GeneticsBackground/ObjectivesTo address the unelucidated mechanisms of breakpoint formation in TFE3-rearranged renal cell carcinoma (TFE3-rRCC), this study characterizes breakpoint distribution within the TFE3 gene.
Xiaopo Zhang +8 more
doaj +2 more sources
Successful Treatment of a Patient with Chronic Myelogenous Leukemia with Concurrent Janus Kinase 2 (JAK2) R795S Mutation and Breakpoint Cluster Region-ABL1 (BCR-ABL1) Fusion: A Case Report and Literature Review. [PDF]
Am J Case Rep, 2020 Yue Y +8 more
europepmc +3 more sources