Results 1 to 10 of about 160,061 (270)

PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle. [PDF]

PLoS ONE, 2015
Scavenger receptor class B, type I (SR-BI) and its adaptor protein PDZK1 mediate responses to HDL cholesterol in endothelium. Whether the receptor-adaptor protein tandem serves functions in other vascular cell types is unknown.
Wan Ru Lee, Anastasia Sacharidou, Erica Behling-Kelly, Sarah C Oltmann, Weifei Zhu, Mohamed Ahmed, Robert D Gerard, David Y Hui, Jun-ichi Abe, Philip W Shaul, Chieko Mineo   +10 more
doaj   +5 more sources

Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation [PDF]

Haematologica, 2020
Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor ...
Malalage N. Peiris, April N. Meyer, Katelyn N. Nelson, Ezra W. Bisom-Rapp, Daniel J. Donoghue   +4 more
doaj   +5 more sources

Huntingtin-associated protein 1 interacts with breakpoint cluster region protein to regulate neuronal differentiation. [PDF]

PLoS ONE, 2015
Alterations in microtubule-dependent trafficking and certain signaling pathways in neuronal cells represent critical pathogenesis in neurodegenerative diseases. Huntingtin (Htt)-associated protein-1 (Hap1) is a brain-enriched protein and plays a key role
Pai-Tsang Huang, Chien-Ho Chen, I-Uen Hsu, Shaima'a Ahmad Salim, Shu-Huei Kao, Chao-Wen Cheng, Chang-Hao Lai, Cheng-Fan Lee, Yung-Feng Lin   +8 more
doaj   +3 more sources

A comprehensive analysis of breakpoint cluster region-abelson fusion oncogene splice variants in chronic myeloid leukemia and their correlation with disease biology.

Indian J Hum Genet, 2014
BACKGROUND: BCR-ABL fusion oncogene is a hallmark of Chronic Myeloid Leukemia (CML). It results due to translocation between chromosome 22 and chromosome 9 [t (9; 22)(q34; q11)].
Iqbal Z.
europepmc   +4 more sources

Mechanism of fragility at BCL2 gene minor breakpoint cluster region during t(14;18) chromosomal translocation. [PDF]

J Biol Chem, 2012
Background: The mechanism of fragility at mcr during t(14;18) translocation is not known. Results: RAGs nick mcr using a unique mechanism involving the CCACCTCT motif, which is critical for its fragility.
Nambiar M, Raghavan SC.
europepmc   +3 more sources

Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions. [PDF]

Leukemia, 2019
For nearly 3 decades, the human MLL (KMT2A) gene and its rearrangements have been investigated in many different laboratories around the world. At our diagnostic center (DCAL Frankfurt), our standard strategy for the identification of MLL-r is based on ...
Meyer C, Lopes BA, Caye-Eude A, Cavé H, Arfeuille C, Cuccuini W, Sutton R, Venn NC, Oh SH, Tsaur G, Escherich G, Feuchtinger T, Kosasih HJ, Khaw SL, Ekert PG, Pombo-de-Oliveira MS, Bidet A, Djahanschiri B, Ebersberger I, Zaliova M, Zuna J, Zermanova Z, Juvonen V, Grümayer RP, Fazio G, Cazzaniga G, Larghero P, Emerenciano M, Marschalek R.   +28 more
europepmc   +2 more sources

Clonal rearrangement and expression of the T cell receptor beta gene and involvement of the breakpoint cluster region in blast crisis of CGL [PDF]

Blood, 1986
A case of lymphoid blast crisis of Ph1-positive CGL is described in which the blast cells had an immature T cell phenotype, clonal rearrangement and expression of the T cell receptor beta gene, and a rearrangement of the breakpoint cluster region (bcr ...
Luen Chow Chan, Andrew J. Furley, AM Ford, DA Yardumian, MF Greaves   +4 more
semanticscholar   +4 more sources

Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP. [PDF]

J Biol Chem, 2014
Background: Src homology 2 domain containing protein 5 (SH2D5) is a previously uncharacterized protein that resembles the Shc proteins in structural organization.
Gray EJ, Petsalaki E, James DA, Bagshaw RD, Stacey MM, Rocks O, Gingras AC, Pawson T.   +7 more
europepmc   +2 more sources

The correlation of breakpoint cluster region rearrangement and p210 phl/abl expression with morphological analysis of Ph-negative chronic myeloid leukemia and other myeloproliferative diseases [PDF]

Blood, 1988
The chromosome 22 derivative, the Philadelphia (Ph) chromosome, results from a reciprocal translocation t(9;22) (q34;q11) and is associated with chronic myeloid leukemia (CML).
LM Wiedemann, KK Karhi, MK Shivji, SI Rayter, SM Pegram, G Dowden, David Bevan, Andrew Will, DA Galton, LC Chan   +9 more
semanticscholar   +4 more sources

A Novel Method for the Detection, Quantitation, and Breakpoint Cluster Region Determination of t(15;17) Fusion Transcripts Using a One-Step Real-Time Multiplex RT-PCR [PDF]

American Journal of Clinical Pathology, 2003
Individuals with acute promyelocytic leukemia (APL) usually express 1 of 3 primary hybrid transcripts associated with a t(15;17). The 3 fusion transcripts are the result of heterogeneous breakpoint cluster regions (bcr) within the promyelocytic leukemia (
Paul Choppa, Jamie Gomez, Horacio G. Vall, Marilyn A. Owens, Henry Rappaport, Jean Lopategui   +5 more
semanticscholar   +3 more sources