Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation [PDF]
Haematologica, 2020 Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor ...
Malalage N. Peiris +4 more
doaj +8 more sources
PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle. [PDF]
PLoS ONE, 2015 Scavenger receptor class B, type I (SR-BI) and its adaptor protein PDZK1 mediate responses to HDL cholesterol in endothelium. Whether the receptor-adaptor protein tandem serves functions in other vascular cell types is unknown.
Wan Ru Lee +10 more
doaj +5 more sources
Huntingtin-associated protein 1 interacts with breakpoint cluster region protein to regulate neuronal differentiation. [PDF]
PLoS ONE, 2015 Alterations in microtubule-dependent trafficking and certain signaling pathways in neuronal cells represent critical pathogenesis in neurodegenerative diseases. Huntingtin (Htt)-associated protein-1 (Hap1) is a brain-enriched protein and plays a key role
Pai-Tsang Huang +8 more
doaj +3 more sources
Indian J Hum Genet, 2014 BACKGROUND: BCR-ABL fusion oncogene is a hallmark of Chronic Myeloid Leukemia (CML). It results due to translocation between chromosome 22 and chromosome 9 [t (9; 22)(q34; q11)].
Iqbal Z.
europepmc +4 more sources
Mechanism of fragility at BCL2 gene minor breakpoint cluster region during t(14;18) chromosomal translocation. [PDF]
J Biol Chem, 2012 Background: The mechanism of fragility at mcr during t(14;18) translocation is not known. Results: RAGs nick mcr using a unique mechanism involving the CCACCTCT motif, which is critical for its fragility.
Nambiar M, Raghavan SC.
europepmc +3 more sources
Kaposi's sarcoma-associated herpesvirus microRNAs repress breakpoint cluster region protein expression, enhance Rac1 activity, and increase in vitro angiogenesis. [PDF]
J Virol, 2015 MicroRNAs (miRNAs) are small, ∼22-nucleotide-long RNAs that regulate gene expression posttranscriptionally. Kaposi's sarcoma-associated herpesvirus (KSHV) encodes 12 pre-miRNAs during latency, and the functional significance of these microRNAs during ...
Ramalingam D, Happel C, Ziegelbauer JM.
europepmc +2 more sources
Clonal rearrangement and expression of the T cell receptor beta gene and involvement of the breakpoint cluster region in blast crisis of CGL. [PDF]
Blood, 1986 A case of lymphoid blast crisis of Ph1-positive CGL is described in which the blast cells had an immature T cell phenotype, clonal rearrangement and expression of the T cell receptor beta gene, and a rearrangement of the breakpoint cluster region (bcr ...
L. Chan +4 more
semanticscholar +4 more sources
Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP. [PDF]
J Biol Chem, 2014 Background: Src homology 2 domain containing protein 5 (SH2D5) is a previously uncharacterized protein that resembles the Shc proteins in structural organization.
Gray EJ +7 more
europepmc +2 more sources
DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis [PDF]
Molecular and Cellular Biology, 1997 A distinct population of therapy-related acute myeloid leukemia (t-AML) is strongly associated with prior administration of topoisomerase II (topo II) inhibitors.
Martin Stanulla +4 more
semanticscholar +2 more sources
The correlation of breakpoint cluster region rearrangement and p210 phl/abl expression with morphological analysis of Ph-negative chronic myeloid leukemia and other myeloproliferative diseases. [PDF]
Blood, 1988 The chromosome 22 derivative, the Philadelphia (Ph) chromosome, results from a reciprocal translocation t(9;22) (q34;q11) and is associated with chronic myeloid leukemia (CML).
L. Wiedemann +9 more
semanticscholar +4 more sources