Results 91 to 100 of about 160,061 (270)

Drug‐induced interstitial lung disease associated with dasatinib coinciding with active tuberculosis

Respirology Case Reports, 2020
A 69‐year‐old woman was diagnosed with a breakpoint cluster region‐Abelson‐positive chronic myeloid leukaemia and treated with dasatinib for 14 months. She presented with one month of high‐grade fever and persistent dry cough.
Nozomi Tani, Yusuke Kunimatsu, Izumi Sato, Yuri Ogura, Kazuki Hirose, Takayuki Takeda   +5 more
doaj   +1 more source

A promising frontier of circulating messenger RNA in liquid biopsy: From mechanisms to clinical applications

International Journal of Cancer, EarlyView.
Abstract Liquid biopsy can revolutionize cancer patient management as repeated sampling allows real‐time monitoring of disease progression and response to treatment. The circulating transcriptome represents a rich source of potential cancer biomarkers, including coding and non‐coding RNAs.
Mengqian Li, Yijin Yu, Guangyue Liu, Shunhong Zhang, Chenchen Luo, Saidi Hu, Siran Wan, Linyong Zhao   +7 more
wiley   +1 more source

Sudden visual loss as an initial manifestation of chronic myeloid leukemia

Saudi Journal of Medicine and Medical Sciences, 2017
Chronic myelogenous leukemia (CML) is a pluripotent stem cell disease characterized by anemia, granulocytosis and granulocytic immaturity, basophilia, thrombocytosis and splenomegaly.
Ahmed N Buzaid, Ali M Al-Amri
doaj   +1 more source

Haplotype‐resolved genome and pan‐genome graphs reveal the impacts of structural variation on functional genome and feather colors in chickens

iMetaOmics, EarlyView.
This study built a Wenchang chicken haplotype genome and integrated it with 29 others to create a chicken pangenome atlas. Analysis of 354 chickens revealed 185,205 structural variations (SVs), with one‐third derived from homology‐based and transposable elements.
Lihong Gu, Chen Peng, Anhong Chen, Kaiyu Chen, Xinli Zheng, Dongyou Yu, Zhengguang Wang, Lingzhao Fang, George E. Liu, Pengju Zhao   +9 more
wiley   +1 more source

Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations

eLife, 2018
Chromosomal translocations are hallmarks of various types of cancers and leukemias. However, the molecular mechanisms of chromosome translocations remain largely unknown.
Jiying Sun, Lin Shi, Aiko Kinomura, Atsuhiko Fukuto, Yasunori Horikoshi, Yukako Oma, Masahiko Harata, Masae Ikura, Tsuyoshi Ikura, Roland Kanaar, Satoshi Tashiro   +10 more
doaj   +1 more source

Hydrological seasonality is a major driver of ecosystem metabolism in tropical nonwadeable rivers

Limnology and Oceanography, EarlyView.
Abstract Studies of annual patterns of ecosystem metabolism in rivers have primarily been conducted in temperate ecosystems, and little is known about metabolic regimes of tropical rivers. We estimated ecosystem metabolism in four nonwadeable rivers in southern México that varied in size and the extent of human disturbance.
María M. Castillo, Amber J. Ulseth, Aarón Jarquín‐Sánchez, Arturo Álvarez‐Merino, Krista A. Capps   +4 more
wiley   +1 more source

Structural variation of the malaria-associated human glycophorin A-B-E region

BMC Genomics, 2020
Background Approximately 5% of the human genome shows common structural variation, which is enriched for genes involved in the immune response and cell-cell interactions. A well-established region of extensive structural variation is the glycophorin gene
Sandra Louzada, Walid Algady, Eleanor Weyell, Luciana W. Zuccherato, Paulina Brajer, Faisal Almalki, Marilia O. Scliar, Michel S. Naslavsky, Guilherme L. Yamamoto, Yeda A. O. Duarte, Maria Rita Passos-Bueno, Mayana Zatz, Fengtang Yang, Edward J. Hollox   +13 more
doaj   +1 more source

Quantification of the breakpoint cluster region rearrangement for clinical monitoring in Philadelphia chromosome-positive chronic myeloid leukemia.

Blood, 1995
The purpose of this report was to evaluate scintigraphy analysis of Southern blot hybridization as a method to quantify the breakpoint cluster region (BCR) rearrangement of Philadelphia chromosome (Ph)+ chronic myelogenous leukemia (CML). Cytogenetic and
C. Verschraegen, M. Talpaz, Cherryl F. Hirsch-Ginsberg, Rakesh Pherwani, M. Rios, S. Stass, H. Kantarjian   +6 more
semanticscholar   +1 more source

Clustering of breakpoints to specific chromosomal regions in human neoplasia. A survey of 5,345 cases

Hereditas, 2008
In an attempt to map breakpoints of prime significance in human cancer and leukemia, all neoplasms with a single structural chromosomal abnormality were ascertained from the Catalog of Chromosome Aberraions in Cancer (1985), and their breakpoints were recorded. Among 5,345 cases reviewed, 318 different types of aberrations were found as the only change
openaire   +3 more sources

Refuge trifecta: intertidal gastropods use pits to escape heat, wave action and predation

Oikos, EarlyView.
Refuges play a critical role in ecology and evolution. In hard intertidal shores, small pits attract benthic invertebrates such as gastropods, however, there exists little mechanistic understanding of the processes driving the active usage of these microhabitat features. We conducted a series of laboratory experiments to assess whether the marine snail
Joel W. Q. Tan, Janine Ledet, Peter A. Todd   +2 more
wiley   +1 more source