Huntingtin-associated protein 1 interacts with breakpoint cluster region protein to regulate neuronal differentiation. [PDF]
Huang PT+8 more
europepmc +1 more source
ABSTRACT Declines in recruitment of lake whitefish (Coregonus clupeaformis) in the Laurentian Great Lakes have been attributed to a reduction in the amount of zooplankton prey available to young life stages, stemming from the ecosystem effects of invasive dreissenid mussels.
Issac Hébert, Erin S. Dunlop
wiley +1 more source
PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle. [PDF]
Lee WR+10 more
europepmc +1 more source
Delineating the Mechanism of Fragility at BCL6 Breakpoint Region Associated With Translocations in Diffuse Large B Cell Lymphoma [PDF]
BCL6 translocation is one of the most common chromosomal translocations in cancer and results in its enhanced expression in germinal center B cells. It involves the fusion of BCL6 with any of its twenty-six Ig and non-Ig translocation partners associated
Choudhary, Bibha+7 more
core +1 more source
Recent Widespread Deceleration of Global Surface Urban Heat Islands Unveiled by Satellites
Abstract Tracking the temporal dynamics of urban heat island (UHI) is critical for urban heat adaptation and mitigation strategies. However, whether UHI trends have shifted recently and their underlying drivers remain unknown. Here we investigate the variabilities in surface UHI trends and their associated determinants in 2,104 cities worldwide from ...
Wenfeng Zhan+11 more
wiley +1 more source
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen+17 more
wiley +1 more source
Promoter replacement by genome editing creates gain‐of‐function traits in Arabidopsis
Plant Biotechnology Journal, EarlyView.
Takashi Nobusawa+3 more
wiley +1 more source
Assessment and Mitigation of CRISPR‐Cas9‐Induced Nontargeted Translocations
Various inverted repeat elements are dispersed throughout genomes. This study reveals that these elements can cause significant chromosomal rearrangements when CRISPR editing occurs in their proximity. The risk can be mitigated by incorporating inverted repeat‐homologous segments into the CRISPR system, which represents a promising strategy for ...
Zhiyang Hou+6 more
wiley +1 more source
This study investigates bidirectional introgression between Chinese and European pig populations, revealing 3558 introgressed genomic segments and 30 structural variations. Analysis of the BMP2 region suggests its role in body size enhancement. By integrating ancient and modern genomes, the study highlights the impact of introgression on genetic ...
Yibin Qiu+19 more
wiley +1 more source
Kaposi's sarcoma-associated herpesvirus microRNAs repress breakpoint cluster region protein expression, enhance Rac1 activity, and increase in vitro angiogenesis. [PDF]
Ramalingam D, Happel C, Ziegelbauer JM.
europepmc +1 more source