Results 111 to 120 of about 30,324 (227)

Integration of Optical Genome Mapping in the Cytogenomic and Molecular Work‐Up of Hematological Malignancies: Expert Recommendations From the International Consortium for Optical Genome Mapping

American Journal of Hematology, Volume 100, Issue 6, Page 1029-1048, June 2025.
ABSTRACT The latest updates to the classification of hematolymphoid malignancies using the World Health Organization (WHO, 5th ed.) and ICC (International Consensus Classification) criteria highlight the critical need for comprehensive and precise cytogenomic data for diagnosis, prognostication, and treatment.
Rashmi Kanagal‐Shamanna, Anna Puiggros, Isabel Granada, Gordana Raca, Katrina Rack, Mar Mallo, Barbara Dewaele, Adam C. Smith, Yassmine Akkari, Brynn Levy, Robert P. Hasserjian, Adela Cisneros, Marta Salido, Guillermo Garcia‐Manero, Hui Yang, M. Anwar Iqbal, Ravindra Kolhe, Francesc Solé, Blanca Espinet   +18 more
wiley   +1 more source

Nilotinib rapidly reverses breakpoint cluster region-Abelson oncogene fusion gene and M244V mutations in a patient with chronic myelogenous leukemia: A case report. [PDF]

Exp Ther Med, 2015
Shen X, Zhang M, Shen Y, Shi W, Liu W, Wei WU.   +5 more
europepmc   +1 more source

Imatinib Desensitization After a Type IV Hypersensitivity Reaction in a Gastrointestinal Stromal Tumor Patient—A Case Report

Cancer Reports, Volume 8, Issue 6, June 2025.
ABSTRACT Background Imatinib treatment is approved for several indications, including chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). Although adverse events are common, hypersensitivity reactions are not. Because there is a clear clinical benefit of imatinib treatment, re‐introduction of imatinib after a hypersensitivity ...
Maud B. A. van der Kleij, Tristan V. M. Bruijn, Raween W. Kalicharan, Yannick S. Elshot, Maxime C. F. Pilon, Mark Oostdijk, Matthijs M. Tibben, Bastiaan Nuijen, Alwin D. R. Huitema, Thomas Rustemeyer, Neeltje Steeghs   +10 more
wiley   +1 more source

Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP. [PDF]

J Biol Chem, 2014
Gray EJ, Petsalaki E, James DA, Bagshaw RD, Stacey MM, Rocks O, Gingras AC, Pawson T.   +7 more
europepmc   +1 more source

Research on Grounding Grid Corrosion Diagnosis Based on Genetic K‐Means Algorithm

Energy Science &Engineering, Volume 13, Issue 6, Page 3074-3087, June 2025.
Flow chart of genetic K‐means algorithm for corrosion diagnosis of grounding grid. ABSTRACT Grounding grid corrosion is one of the main reasons that affect the stable operation of electrical equipment in substations and endanger personal safety. After many years of operation, the grounding conductors will be eroded by soil.
Longsheng Huang, Xianghui Xiao, Mingxian Huang, Zhenshan Zhang, Yunhao Song, Luchang Guan   +5 more
wiley   +1 more source

A novel genotyping system based on site polymorphism on spike gene reveals the evolutionary pathway of porcine epidemic diarrhea virus

iMetaOmics, Volume 2, Issue 2, June 2025.
This study focuses on porcine epidemic diarrhea virus (PEDV), a highly virulent and rapidly evolving coronavirus threatening global swine production. We established a novel genotype system of PEDV targeting site‐specific polymorphisms in the spike (S) protein.
Mingkai Lei, Huimin Li, Xiaoyu Chen, Xiaozhen Li, Xuexiang Yu, Shengnan Ruan, Hao Wu, Ahmed H. Ghonaim, Ziyang Yan, Wentao Li, Qigai He   +10 more
wiley   +1 more source

Applying the National Genomic DNA Reference Materials to Evaluate the Performance of Nanopore Sequencing in Identifying Thalassemia Variants

Journal of Clinical Laboratory Analysis, Volume 39, Issue 11, June 2025.
This study mainly to evaluate the performance of nanopore technology in thalassemia detection by utilizing the national genomic reference materials in China. We proved that the reference materials can be used to evaluate the performance of nanopore sequencing in identifying thalassemia mutations, and it's necessary to incorporate triplicates when ...
Xingyu Wei, Xu Yang, Wanqing Han, Li Zhang, Guojun Ouyang, Shoufang Qu, Fang Yang, Xuexi Yang   +7 more
wiley   +1 more source

Long‐Read Sequencing: The Third Generation of Diagnostic Testing for Dystonia

Movement Disorders, Volume 40, Issue 6, Page 1009-1019, June 2025.
Abstract Long‐read sequencing methodologies provide powerful capacity to identify all types of genomic variations in a single test. Long‐read platforms such as Oxford Nanopore and PacBio have the potential to revolutionize molecular diagnostics by reaching unparalleled accuracies in genetic discovery and long‐range phasing.
Thomas Wirth, Kishore R. Kumar, Michael Zech   +2 more
wiley   +1 more source

Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang, Minqiao Lu, Yi Zhang, Jiangwen Ma, Ying Hu   +4 more
wiley   +1 more source

Mechanism of fragility at BCL2 gene minor breakpoint cluster region during t(14;18) chromosomal translocation. [PDF]

J Biol Chem, 2012
Nambiar M, Raghavan SC.
europepmc   +1 more source