Results 141 to 150 of about 32,784 (274)

Detection of breakpoint cluster region- negative and nonclonal hematopoiesis in vitro and in vivo after transplantation of cells selected in cultures of chronic myeloid leukemia marrow [PDF]

, 1990
Ali G. Turhan, R. Keith Humphries, CJ Eaves, MJ Barnett, GL Phillips, DK Kalousek, Klingemann Hg, P. M. Lansdorp, DE Reece, JD Shepherd   +9 more
openalex   +3 more sources

New cell lines expanding the diversity of Ewing sarcoma models

International Journal of Cancer, Volume 158, Issue 3, Page 642-655, 1 February 2026.
What's new? A chromosomal translocation between the EWSR1 and ETS genes is the key oncogenic driver in Ewing sarcoma. EWSR1::FLI1, the most frequent fusion, is subdivided into different fusion types with unclear prognostic relevance. Here, the authors describe the establishment and characterization of four new, intrinsically immortal, patient‐derived ...
Maximilian Kerkhoff, Christiane Schaefer, Wilhelm G. Dirks, Dawid Krzeciesa, Maximilian Bretschneider, Pauline R. Plaumann, Wiebke K. Guder, Arne Streitbürger, Sonja Herter, Heike Peterziel, Ina Oehme, Felina Zahnow, Thomas G. P. Grünewald, Uta Dirksen   +13 more
wiley   +1 more source

THE HISTORY OF CHRONIC MYELOID LEUKEMIA (CML): FROM ARSENIC TO TYROSINE KINASE INHIBITORS (TKI)

Hematology, Transfusion and Cell Therapy
It took 20-years from the first description of CML in 1845 to the report by Lissauer in 1865, of an effective treatment with arsenic. After another 38-years the beneficial effect of splenic irradiation was described in 1903, and after 50 more years the ...
Rüdiger Hehlmann
doaj   +1 more source

Correction: Breakpoint Cluster Region–Mediated Inflammation Is Dependent on Casein Kinase II [PDF]

The Journal of Immunology, 2017
Jie, Meng, Jing-Jing, Jiang, Toru, Atsumi, Hidenori, Bando, Yuko, Okuyama, Lavannya, Sabharwal, Ikuma, Nakagawa, Haruka, Higuchi, Mitsutoshi, Ota, Momoko, Okawara, Ryuichiro, Ishitani, Osamu, Nureki, Daisuke, Higo, Yasunobu, Arima, Hideki, Ogura, Daisuke, Kamimura, Masaaki, Murakami   +16 more
openaire   +2 more sources

Septic Shock Caused by Coinfection of Shewanella algae Bloodstream Infection and Epstein‐Barr Virus: Clinical Characteristics and Genomic Analysis

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
This study reports a septic shock case in inland China caused by coinfection of Shewanella algae bloodstream infection and Epstein‐Barr virus. Genomic analysis revealed freshwater adaptation of the strain via unique genes for transporters and carbohydrate‐active enzymes.
Jianmei Chen, Dong Ling, Feng Wang, Liping Liu, Yucheng Ren, Chengying Chen, Na Su   +6 more
wiley   +1 more source

Identification of the motifs of beta-turns and mutated amino acids studies on BCR (Breakpoint cluster region) protein using Insilico techniques

, 2020
Anuradha Manogharan, Regina Mary Rathina Sami, Ramadevi Mohan   +2 more
openalex   +1 more source

Exploring the Potential and Evaluating Hydrocarbon Degradation by Novel Antarctic Dietzia and Pusillimonas Isolates From a Pristine Environment

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
The Antarctic Dietzia and Pusillimonas isolates were tested for bioremediation applications. Genomic analyses revealed the potential to degrade complex organic compounds, potential virulence factors and resistance genes. Physiological assays showed a wide range of adaptation to abiotic factors and sensitivity to different groups of antibiotics ...
Tomasz Krucoń, Julia Karbowska, Wiktoria Pietrowicz, Robert Stasiuk, Łukasz Drewniak   +4 more
wiley   +1 more source

Rearrangement of the breakpoint cluster region in Philadelphia chromosome positive acute leukemia.

Acta medica Okayama, 1988
The rearrangement of breakpoint cluster region (ber) was examined in leukemic cells obtained from 3 patients initially diagnosed as having Ph+ acute leukemia, 2 with acute lymphocytic leukemia (ALL) and one with acute mixed leukemia. DNA was digested with Bgl II and BamH I. The ber rearrangement was present in the case of acute mixed leukemia (Case 1),
I, Takahashi, N, Sekito, M, Takeuchi, K, Osada, T, Matsuzaki, S, Fukuda, M, Lai, K, Uchida, I, Kimura, K, Miyamoto   +9 more
openaire   +1 more source

ATAD3 duplications bridge mitochondrial diseases and Aicardi–Goutières syndrome

Developmental Medicine &Child Neurology, Volume 68, Issue 2, Page 287-294, February 2026.
ATAD3 locus duplications cause a severe neonatal mitochondrial disorder with neuroimaging features resembling interferonopathies, and suggest a mitochondrial nucleic acid‐triggered interferon response. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16446 Abstract A recurrent 68‐kb heterozygous duplication of the ATAD3 locus ...
Pauline Planté‐Bordeneuve, Claire‐Marine Bérat, Sylvain Hanein, Cyril Gitiaux, ATAD3 Study Group, Julie Steffann, Isabelle Desguerre, Agnès Rötig, Nathalie Boddaert, Giulia Barcia, Brian Sperelakis‐Beedham, Zahra Assouline, Marie‐Thérèse Abi‐Warde, Rukhshona Abdullazoda, Agnès Guichet, Céline Bris, Aurélien Caux, Marlène Rio, Jérémy Bertrand, Pauline Gaignard, Alice Lepelley, Arnold Munnich, Manuel Schiff, Isabelle Desguerre, Agnès Rötig, Nathalie Boddaert, Giulia Barcia   +26 more
wiley   +1 more source

Mechanisms of enhancer‐driven oncogene activation

International Journal of Cancer, Volume 158, Issue 2, Page 333-341, 15 January 2026.
Abstract An aggressive subtype of acute myeloid leukemia (AML) is caused by enhancer hijacking resulting in MECOM overexpression. Several chromosomal rearrangements can lead to this: the most common (inv(3)/t(3;3)) results in a hijacked GATA2 enhancer, and there are several atypical MECOM rearrangements involving enhancers from other hematopoietic ...
Joyce Vriend, Ruud Delwel, Dorien Pastoors   +2 more
wiley   +1 more source