Results 181 to 190 of about 30,324 (227)

Cloning of a breakpoint cluster region on chromosome 14 in uterine leiomyoma

Cancer Letters, 1998
A recurrent reciprocal chromosomal translocation, t(12;14)(q15;q24) is frequently observed in uterine leiomyoma. Chromosome 12 breakpoints have been shown to occur in a region of approximately 150 kb that contains the gene for a high mobility group protein (HMGI-C). The breakpoint region on chromosome 14 has not been precisely defined.
Bindu Bhugra, Roy A. Lynch, Teresa A. Smolarek, Larry L. Deaven, Aurelia M Meloni, Anil G. Menon, Avery A. Sandberg   +6 more
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MLL Genomic Breakpoint Distribution Within the Breakpoint Cluster Region in De Novo Leukemia in Children

Journal of Pediatric Hematology/Oncology, 1998
To assess translocation breakpoint distribution within the MLL genomic breakpoint cluster region (bcr), 40 cases of de novo leukemia in children were examined by karyotype and Southern blot analysis.Criteria for inclusion were karyotypic or molecular rearrangement of chromosome band 11q23. Of the 40 cases, 31 occurred in infants.
Peter C. Nowell, Matthew R. Hosler, Timothy R. Rebbeck, James A. Whitlock, Robert I. Parker, Carolyn A. Felix, Beverly J. Lange, Margaret Masterson, Diana J. Slater   +8 more
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Philadelphia-positive chronic myelogenous leukemia with breakpoint 5? of the breakpoint cluster region but within the bcr gene

Blut, 1987
We report on the first Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) characterized by a rearrangement within the 5' part of the bcr gene on chromosome 22, but outside the restricted breakpoint cluster region. In situ hybridization studies revealed a translocation of the c-abl oncogene to the Ph chromosome and Northern blot ...
H. Schmidt, H. D. Waller, Claus R. Bartram, Ulrike Bross-Bach   +3 more
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The Breakpoint Cluster Region Gene on Chromosome 22q11 is Associated with Bipolar Disorder

Biological Psychiatry, 2005
Although the pathogenesis of bipolar disorder remains unclear, heritable factors have been shown to be involved. The breakpoint cluster region (BCR) gene is located on chromosome 22q11, one of the most significant susceptibility loci in bipolar disorder linkage studies.
Kunitoshi Kamijima, Hiroshi Kunugi, M Tatsumi, Ryota Hashimoto, Takeya Okada, Tadafumi Kato, Asako Kosuga   +6 more
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[15] Characterization of breakpoint cluster region kinase and SH2-binding activities

1995
BCR is an interesting signaling protein, whose cellular function is currently unknown. Its biochemical properties include serine kinase activity, SH2-binding activity, and a GTPase-activating activity. The SH2-binding activity is particularly interesting because it may link BCR to signaling pathways involving SH2-containing molecules.
Daniel E. H. Afar, Owen N. Witte
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Aberrant hypermethylation of the major breakpoint cluster region in 17p11.2 in medulloblastomas but not supratentorial PNETs

Genes, Chromosomes and Cancer, 2000
Deletions of 17p have been consistently reported in up to 50% of medulloblastomas (MBs), and the major breakpoint interval has been localized to chromosome segment 17p11.2. Based on several reports linking aberrant DNA methylation and chromosomal disruption, we examined the methylation pattern in this region by employing restriction landmark genomic ...
Frühwald, Michael C., O'Dorisio, M. S., Dai, Z., Rush, L. J., Krahe, R., Smiraglia, D. J., Pietsch, T., Elsea, S. H., Plass, C.   +8 more
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CML with E8A2 BCR-ABL Fusion: The Fourth Breakpoint Cluster Region?.

Blood, 2004
Abstract In Ph+ leukemia, the breakpoints within BCR cluster in 3 distinct breakpoint cluster regions (bcr). Rearrangements in the minor (m−), major (M−) and micro (m−) breakpoint cluster region (bcr) give rise to e1a2, e13/14a2 and e19a2 BCR-ABL fusion proteins that are associated with Ph+ ALL, CML and chronic neutrophilic leukemia ...
Shadmehr Demehri, Takeshi Sugimoto, Lay-cheng Lim, Michael W. Deininger, Tamio Koizumi, Beate Schultheis, Thoralf Lange, Peter Paschka, Brian J. Druker, Susan Branford, Andreas Hochhaus, Thomas Kegel, Giovanni Martinelli   +12 more
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Myeloid- and lymphoid-specific breakpoint cluster regions in chromosome band 13q14 in acute leukemia [PDF]

Genes, Chromosomes and Cancer, 1999
Abnormalities of chromosome band 13q14 occur in hematologic malignancies of all lineages and at all stages of differentiation. Unlike other chromosomal translocations, which are usually specific for a given lineage, the chromosomal translocation t(12;13)(p12;q14) has been observed in both B-cell and T-cell precursor acute lymphoblastic leukemia (BCP ...
L. J. A. Coignet, Martin J. S. Dyer, Carmen S Lima, John Swansbury, Masami Nagai, Berthold Streubel, Angela L Bowen, Christa Fonatsch, Nick Telford, Toon Min, Soheila Swanton, Daniel Catovsky   +11 more
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Human Follicular Lymphomas: Identification of a Second t(14;18) Breakpoint Cluster Region

1987
Most follicular lymphomas, which comprise nearly two-thirds of the non-Hodgkin’s lymphomas occurring in U.S. adults, have been shown by cytogenetic analyses to contain a t(14;18) translocation [1, 2]. This breakpoint on chromosome 14 has been localized to band 14q32, the site of the immunoglobulin heavy chain genes. It was thus possible to use human Ig
Jeffrey Sklar, Michael L. Cleary, Naomi Galili   +2 more
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Molecular Analysis of Acute Promyelocytic Leukemia Breakpoint Cluster Region on Chromosome 17

Science, 1990
Acute promyelocytic leukemia (APL; FAB M3) is characterized by a predominance of malignant promyelocytes that carry a reciprocal translocation between the long arms of chromosomes 15 and 17, t(15;17)(q22;q11.2-q12). This translocation has become diagnostic for APL, as it is present in almost 100 percent of cases.
Denise Sheer, Ellen Solomon, Julian Borrow, Audrey Goddard   +3 more
openaire   +3 more sources