Paternal origin of the rearranged major breakpoint cluster region in chronic myeloid leukemia [PDF]
Blood, 1994 Abstract The Philadelphia chromosome, t(9;22), is present in virtually all cases of chronic myeloid leukemia (CML). It has previously been shown by cytogenetic studies that the rearranged chromosome 22 in patients with CML is exclusively maternal in origin.
CE Litz, CM Copenhaver
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BCL6 alternative translocation breakpoint cluster region associated with follicular lymphoma grade 3B [PDF]
Genes, Chromosomes and Cancer, 2005 AbstractTranslocations involving band 3q27, affecting the major breakpoint region (MBR) of BCL6, are common in diffuse large B‐cell lymphomas (DLBCLs). Recent data suggest an alternative breakpoint cluster region (ABR) located between 245 and 285 kb 5′ of BCL6, which might be associated with Follicular Lymphoma (FL).
Anneke Bosga-Bouwer +8 more
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Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas. [PDF]
The Journal of experimental medicine, 1986 Our results indicate that there are two major breakpoint cluster regions in chromosome 18 DNA for t(14;18) translocations in follicular lymphomas. The absence of a pFL-1 homologous transcript in a cell line containing a pFL-2-detectable translocation suggests that there may be two different pathogenetic consequences of t(14;18) translocations.
Michael L. Cleary +2 more
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Duplication of small segments within the major breakpoint cluster region in chronic myelogenous leukemia [PDF]
Blood, 1993 Abstract The t(9;22) in chronic myelogenous leukemia (CML) may be reciprocal or, in a minority of cases, may result in an extensive deletion of a portion of the major breakpoint cluster region (M-bcr) of the BCR. This report provides evidence of the duplication of small segments within the M-bcr in a small group of patients with CML ...
CE Litz +3 more
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Nilotinib rapidly reverses breakpoint cluster region-Abelson oncogene fusion gene and M244V mutations in a patient with chronic myelogenous leukemia: A case report. [PDF]
Exp Ther Med, 2015 Shen X +5 more
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Coexistence of breakpoint cluster region-Abelson1 rearrangement and Janus kinase 2 V617F mutation in chronic myeloid leukemia: A case report. [PDF]
World J Clin Cases, 2019 Shi XB, Jiang JF, Jin FX, Cheng W.
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Two novel translocation breakpoints upstream of SOX9 define borders of the proximal and distal breakpoint cluster region in campomelic dysplasia [PDF]
Clinical Genetics, 2006 The semilethal skeletal malformation syndrome campomelic dysplasia (CD) with or without XY sex reversal is caused by mutations within the SOX9 gene on 17q24.3 or by chromosomal aberrations (translocations, inversions or deletions) with breakpoints outside the SOX9 coding region.
M. Leipoldt +10 more
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Iraqi Journal of Hematology, 2023 BACKGROUND: Chronic myeloid leukemia (CML) has been well recognized as an exemplary instance of a malignant disease characterized by a distinctive molecular occurrence, namely the presence of the breakpoint cluster region (BCR)-c-ABL oncogene 1 (ABL1 ...
Aseel Majeed Hameed +3 more
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Radiology and Oncology, 2023 t(14;18)(q32;q21) translocation is an important genetic feature of follicular lymphoma resulting in antiapoptotic B-cell lymphoma 2 (BCL2) protein overexpression. On chromosome 18 breakpoint-site variation is high but does not affect BCL2.
Panjan Matej +4 more
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VNTR polymorphism in the breakpoint region of ABL1 and susceptibility to bladder cancer
BMC Medical Genomics, 2021 Background ABL1 is primarily known as a leukemia-related oncogene due to translocation, but about 2.2% of ABL1 mutations have been identified in bladder cancer, and high expression in solid cancer has also been detected.
Min-Hye Kim +8 more
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