Comparative Expression Analysis of Breakpoint Cluster Region-Abelson Oncogene in Leukemia Patients. [PDF]
ACS Omega, 2023 Leukemia is a proliferative disorder of myeloid and lymphoid cells that may lead to death. Different types of leukemia have been reported, and several genetic and environmental factors are involved in their development. The Philadelphia chromosome causes the most common mutation known as breakpoint cluster region-Abelson oncogene (BCR-ABL1), which ...
Arshad F +9 more
europepmc +3 more sources
Cancer chromosome breakpoints cluster in gene‐rich genomic regions [PDF]
Genes, Chromosomes and Cancer, 2018 AbstractCancer cells are characterized by chromosome abnormalities, of which some, in particular balanced rearrangements, are associated with distinct tumor entities and/or with specific gene rearrangements that represent important steps in the carcinogenic process.
Felix Mitelman +4 more
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Aberrant methylation of the major breakpoint cluster region in chronic myeloid leukemia [PDF]
Blood, 1996 Isolated hypomethylated sites exist in the major breakpoint cluster region (M-bcr) where most Philadelphia chromosome (Ph) breakpoints are located. Twenty of 50 (40%) chronic myeloid leukemia (CML) patients were found to have aberrant hypermethylation of these sites on the rearranged M-bcr when compared with control marrows.
Cedith M. Copenhaver +2 more
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Breakpoint Cluster Region–Mediated Inflammation Is Dependent on Casein Kinase II [PDF]
The Journal of Immunology, 2016 Abstract The breakpoint cluster region (BCR) is known as a kinase and cause of leukemia upon fusing to Abl kinase. In this study, we demonstrate that BCR associated with the α subunit of casein kinase II (CK2α), rather than BCR itself, is required for inflammation development.
Jie Meng +16 more
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BCR (breakpoint cluster region) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2010 Review on BCR (breakpoint cluster region), with data on DNA, on the protein encoded, and where the gene is implicated.
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Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas. [PDF]
The Journal of experimental medicine, 1986 Our results indicate that there are two major breakpoint cluster regions in chromosome 18 DNA for t(14;18) translocations in follicular lymphomas. The absence of a pFL-1 homologous transcript in a cell line containing a pFL-2-detectable translocation suggests that there may be two different pathogenetic consequences of t(14;18) translocations.
Jeffrey Sklar +2 more
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Paternal origin of the rearranged major breakpoint cluster region in chronic myeloid leukemia [PDF]
Blood, 1994 Abstract The Philadelphia chromosome, t(9;22), is present in virtually all cases of chronic myeloid leukemia (CML). It has previously been shown by cytogenetic studies that the rearranged chromosome 22 in patients with CML is exclusively maternal in origin.
Craig E. Litz, Cedith M. Copenhaver
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Aphidicolin-Induced FRA3B Breakpoints Cluster in Two Distinct Regions
Genomics, 1997 The common fragile site at chromosomal band 3p14.2 (FRA3B) is the most sensitive single site in the human genome to induced chromosomal lesions. This fragile site may predispose chromosome 3p to breakage that is commonly observed in lung, renal, and many other cancers.
Ravi Shridhar +7 more
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Genome reorganization in different cancer types: detection of cancer specific breakpoint regions [PDF]
, 2019 Background: Tumorigenesis is a multi-step process which is accompanied by substantial changes in genome organization. The development of these changes is not only a random process, but rather comprise specific DNA regions that are prone to the ...
Klein, Andreas +3 more
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Multi-wavelength Stellar Polarimetry of the Filamentary Cloud IC5146: I. Dust Properties [PDF]
, 2017 We present optical and near-infrared stellar polarization observations toward the dark filamentary clouds associated with IC5146. The data allow us to investigate the dust properties (this paper) and the magnetic field structure (Paper II).
Chen, Wen-Ping +5 more
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