BCR (breakpoint cluster region) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on BCR (breakpoint cluster region), with data on DNA, on the protein encoded, and where the gene is implicated.
Ali G. Turhan
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Comparative Expression Analysis of Breakpoint Cluster Region-Abelson Oncogene in Leukemia Patients. [PDF]
ACS Omega, 2023 Leukemia is a proliferative disorder of myeloid and lymphoid cells that may lead to death. Different types of leukemia have been reported, and several genetic and environmental factors are involved in their development. The Philadelphia chromosome causes the most common mutation known as breakpoint cluster region-Abelson oncogene (BCR-ABL1), which ...
Arshad F +9 more
europepmc +4 more sources
Nucleolytic Cleavage of the Mixed Lineage Leukemia Breakpoint Cluster Region during Apoptosis [PDF]
Journal of Biological Chemistry, 2001 VP-16 (etoposide) has recently been shown to induce topoisomerase II (TOP2)-mediated DNA cleavage within the mixed lineage leukemia (MLL) breakpoint cluster region (bcr), suggesting a role of TOP2 in MLL gene rearrangement.
Sai-Peng Sim, Leroy F. Liu
semanticscholar +6 more sources
Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas. [PDF]
The Journal of experimental medicine, 1986 Our results indicate that there are two major breakpoint cluster regions in chromosome 18 DNA for t(14;18) translocations in follicular lymphomas. The absence of a pFL-1 homologous transcript in a cell line containing a pFL-2-detectable translocation ...
Michael L. Cleary +2 more
semanticscholar +5 more sources
Two novel translocation breakpoints upstream of SOX9 define borders of the proximal and distal breakpoint cluster region in campomelic dysplasia [PDF]
Clinical Genetics, 2006 The semilethal skeletal malformation syndrome campomelic dysplasia (CD) with or without XY sex reversal is caused by mutations within the SOX9 gene on 17q24.3 or by chromosomal aberrations (translocations, inversions or deletions) with breakpoints outside the SOX9 coding region.
M. Leipoldt +10 more
semanticscholar +6 more sources
Mutations in the breakpoint cluster region-Abelson murine leukemia 1 gene in Brazilian patients with chronic myeloid leukemia [PDF]
Hematology, Transfusion and Cell Therapy, 2018 Introduction: Mutations in the breakpoint cluster region-Abelson murine leukemia 1 gene are the leading cause of resistance to treatment with tyrosine kinase inhibitors in chronic myeloid leukemia patients.
Heloísa Zorzi Costa +5 more
doaj +2 more sources
Id1 Transcription Inhibitor–Matrix Metalloproteinase 9 Axis Enhances Invasiveness of the Breakpoint Cluster Region/Abelson Tyrosine Kinase–Transformed Leukemia Cells [PDF]
Cancer Research, 2006 Breakpoint cluster region/Abelson (BCR/ABL) tyrosine kinase enhances the ability of leukemia cells to infiltrate various organs. We show here that expression of the helix-loop-helix transcription factor Id1 is enhanced by BCR/ABL in a signal transducer ...
Margaret Nieborowska-Skorska +6 more
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Proceedings of the National Academy of Sciences of the United States of America, 1985 The t(14;18)(q32;21) chromosomal translocation characteristic of follicular lymphomas is the most common cytogenetic abnormality known to be associated with any specific type of hematolymphoid malignancy.
Michael L. Cleary, Jeffrey Sklar
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Coexistence of breakpoint cluster region-Abelson1 rearrangement and Janus kinase 2 V617F mutation in chronic myeloid leukemia: A case report. [PDF]
World J Clin Cases, 2019 Shi XB, Jiang JF, Jin FX, Cheng W.
europepmc +2 more sources
Kaposi's sarcoma-associated herpesvirus microRNAs repress breakpoint cluster region protein expression, enhance Rac1 activity, and increase in vitro angiogenesis. [PDF]
J Virol, 2015 Ramalingam D, Happel C, Ziegelbauer JM.
europepmc +2 more sources