Results 211 to 220 of about 160,061 (270)

Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17.

Science, 1990
Acute promyelocytic leukemia (APL; FAB M3) is characterized by a predominance of malignant promyelocytes that carry a reciprocal translocation between the long arms of chromosomes 15 and 17, t(15;17) (q22;q11.2-q12).
J. Borrow, A. Goddard, D. Sheer, E. Solomon   +3 more
semanticscholar   +4 more sources

Rearrangement in the breakpoint cluster region and the clinical course in Philadelphia-negative chronic myelogenous leukemia.

Annals of Internal Medicine, 1986
We have followed one patient with Philadelphia (Ph)-negative chronic myelogenous leukemia and identified an additional four patients from the literature who showed the rearrangement in the breakpoint cluster region (bcr) on chromosome 22 characteristic ...
R. Kurzrock, M. Blick, M. Talpaz, W. Velasquez, J. Trujillo, N. Kouttab, W. Kloetzer, R. Arlinghaus, J. Gutterman   +8 more
semanticscholar   +4 more sources

How does the novel T315L mutation of breakpoint cluster region-abelson (BCR-ABL) kinase confer resistance to ponatinib: a comparative molecular dynamics simulation study

Journal of Biomolecular Structure and Dynamics, 2020
Acute lymphocytic leukemia (ALL) is one of the most dangerous types of leukemia, and about 40% of them is Philadelphia chromosome-positive acute lymphocytic leukemia (Ph + ALL).
Hao Zhang, Xinheng He, D. Ni, Linkai Mou, Xiangyu Chen, Shaoyong Lu   +5 more
semanticscholar   +1 more source

MLL Genomic Breakpoint Distribution Within the Breakpoint Cluster Region in De Novo Leukemia in Children

Journal of Pediatric Hematology/Oncology, 1998
To assess translocation breakpoint distribution within the MLL genomic breakpoint cluster region (bcr), 40 cases of de novo leukemia in children were examined by karyotype and Southern blot analysis.Criteria for inclusion were karyotypic or molecular rearrangement of chromosome band 11q23. Of the 40 cases, 31 occurred in infants.
C. Felix, M. R. Hosler, D. Slater, R. Parker, M. Masterson, J. Whitlock, T. Rebbeck, P. Nowell, B. Lange   +8 more
semanticscholar   +4 more sources

Polymorphisms in the MLL breakpoint cluster region (BCR)

Human Genetics, 2003
The MLL gene is involved in many chromosomal translocations leading to both acute myeloid and lymphoid leukemia. Some patients treated for primary malignancies with chemotherapeutic agents that inhibit DNA topoisomerase II (topo II) develop treatment-related leukemia (t-AML) caused by MLL gene rearrangement.
Richard A. Larson, Tomohiko Taki, Nancy J. Zeleznik-Le, Reiner Strick, Reiner Strick, Susan C. Raimondi, Janet D. Rowley, Vandana Gupta, Loretta S. Li, Yasuhide Hayashi, Jhula Banerjee, Lydia L. Smith, Mary V. Relling, Pamela L. Strissel, Pamela L. Strissel, Deborah R. Echlin-Bell, Deborah R. Echlin-Bell   +16 more
openaire   +3 more sources

The genomic breakpoint in a patient with Philadelphia-positive acute leukemia is 5′ of the breakpoint cluster region

Cancer Genetics and Cytogenetics, 1988
We report a case of acute leukemia in which studies at presentation showed both myeloid and lymphoid cell surface markers. At relapse membrane markers studies were consistent with a leukemia of B-lymphoid lineage. However, immunoglobulin (Ig) and T cell receptor (TCR) beta chain genes were both found in a rearranged configuration.
Lucio Luzzatto, John M. Goldman, Letizia Foroni, Daniel Catovsky, Orna Dreazen, Leanne M. Wiedemann, Stephen Legon, Amin Rahemtulla, Feyruz V. Rassool, Guo Ai-Pu   +9 more
openaire   +3 more sources

Cloning of a breakpoint cluster region on chromosome 14 in uterine leiomyoma

Cancer Letters, 1998
A recurrent reciprocal chromosomal translocation, t(12;14)(q15;q24) is frequently observed in uterine leiomyoma. Chromosome 12 breakpoints have been shown to occur in a region of approximately 150 kb that contains the gene for a high mobility group protein (HMGI-C). The breakpoint region on chromosome 14 has not been precisely defined.
Bindu Bhugra, Roy A. Lynch, Teresa A. Smolarek, Larry L. Deaven, Aurelia M Meloni, Anil G. Menon, Avery A. Sandberg   +6 more
openaire   +3 more sources

Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia [PDF]

Oncogene, 2000
A region on chromosome 14q32.1 is often involved in chromosomal translocations and inversions with one of the T-cell receptor loci in T-cell lymphoproliferative diseases. The breakpoints of the different rearrangements segregate into two clusters; a cluster due to inversion on the centromeric side and a cluster due to simple balanced translocations on ...
M. Saitou, J. Sugimoto, T. Hatakeyama, G. Russo, M. Isobe   +4 more
semanticscholar   +4 more sources

Discovery of new benzothiazole-based inhibitors of breakpoint cluster region-Abelson kinase including the T315I mutant.

Journal of Medicinal Chemistry, 2013
The existence of drug resistance caused by mutations in the break-point cluster region-Abelson tyrosine kinase (Bcr-Abl) kinase domain remains a clinical challenge due to limited effective treatment options for chronic myeloid leukemia (CML).
Seunghee Hong, Jinhe Kim, S. Yun, Hyunseung Lee, Y. Park, Soon-Sun Hong, Sungwoo Hong   +6 more
semanticscholar   +1 more source