Results 231 to 240 of about 160,061 (270)

Human Follicular Lymphomas: Identification of a Second t(14;18) Breakpoint Cluster Region

1987
Most follicular lymphomas, which comprise nearly two-thirds of the non-Hodgkin’s lymphomas occurring in U.S. adults, have been shown by cytogenetic analyses to contain a t(14;18) translocation [1, 2]. This breakpoint on chromosome 14 has been localized to band 14q32, the site of the immunoglobulin heavy chain genes. It was thus possible to use human Ig
Jeffrey Sklar, Michael L. Cleary, Naomi Galili   +2 more
openaire   +3 more sources

Breakpoint cluster region rearrangements in chronic myelogenous leukemia with a masked Philadelphia chromosome

Cancer Genetics and Cytogenetics, 1987
Cytogenetic and molecular analyses were performed in a case of chronic myelogenous leukemia. The cytogenetic study revealed that the leukemic cells of this patient contained a three-way translocation involving chromosomes #5, #9, and #22, resulting in a masked Philadelphia chromosome; the karyotype of the leukemic cells was 46,XY,t(5;22;9)(q31;q11;q34).
Junko H. Ohyashiki, Alan J. Kinniburgh, Azra Raza, Avery A. Sandberg, Harvey D. Preisler, Kazuma Ohyashiki   +5 more
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Myeloid- and lymphoid-specific breakpoint cluster regions in chromosome band 13q14 in acute leukemia [PDF]

Genes, Chromosomes and Cancer, 1999
Abnormalities of chromosome band 13q14 occur in hematologic malignancies of all lineages and at all stages of differentiation. Unlike other chromosomal translocations, which are usually specific for a given lineage, the chromosomal translocation t(12;13)(p12;q14) has been observed in both B-cell and T-cell precursor acute lymphoblastic leukemia (BCP ...
L. J. A. Coignet, Martin J. S. Dyer, Carmen S Lima, John Swansbury, Masami Nagai, Berthold Streubel, Angela L Bowen, Christa Fonatsch, Nick Telford, Toon Min, Soheila Swanton, Daniel Catovsky   +11 more
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Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

Cell, 1984
We have identified and molecularly cloned 46 kb of human DNA from chromosome 22 using a probe specific for the Philadelphia (Ph') translocation breakpoint domain of one chronic myelocytic leukemia (CML) patient. The DNAs of 19 CML patients were examined for rearrangements on chromosome 22 with probes isolated from this cloned region.
John Groffen, de Klein A, Nora Heisterkamp, Stephenson, Gerard Grosveld, Claus R. Bartram   +5 more
openaire   +2 more sources

Distribution of breakpoint within the breakpoint cluster region (bcr) in chronic myelogenous leukemia with a complex philadelphia chromosome translocation

American Journal of Hematology, 1989
AbstractWe analyzed, by Southern blot hybridization, the site of breakpoint within the breakpoint cluster region (bcr) in six patients with a complex Philadelphia chromosome (Ph) translocation and in 23 unselected patients with a standard Ph. The breakpoint was found within the 5.8 kb bcr in all 29 patients. When the bcr was subdivided into four parts,
Shigeo Horiike, Hikari Nishigaki, Shoichiro Tsuda, Shinichi Misawa, Masafumi Taniwaki, Tsukasa Okuda, Johji Inazawa, Tatsuo Abe, Kazuhiro Nishida   +8 more
openaire   +3 more sources

Strategy for Breakpoint Cluster Region Analysis in Chronic Myelocytic Leukemia in a Routine Clinical Laboratory

American Journal of Clinical Pathology, 1990
Despite the increasing reliance on breakpoint cluster region (bcr) determinations in diagnosis of chronic myelocytic leukemia (CML), few reports have dealt with the practical aspects of specimen analysis. In the setting of a routine molecular diagnostics laboratory, samples from 68 patients with active CML were evaluated for bcr rearrangements, with ...
Haber, L. M., Childs, C. C., Hirsch-Ginsberg, C., Nellis, K., Kantarjian, H. M., Cork, A., Trujillo, J. M., Stass, S. A.   +7 more
openaire   +4 more sources

Mechanisms of MLL gene rearrangement: site-specific DNA cleavage within the breakpoint cluster region is independent of chromosomal context.

Human Molecular Genetics, 2001
The MLL gene at chromosome band 11q23 is specifically cleaved at a unique site within its breakpoint cluster region (bcr) during the higher order chromatin fragmentation associated with apoptosis. We now show that the same specific DNA cleavage event can
M. Stanulla, P. Chhalliyil, J. Wang, S. Jani-Sait, P. Aplan   +4 more
semanticscholar   +1 more source

Transposition of breakpoint cluster region (3′ bcr) in CML cells with variant Philadelphia translocations

Cancer Genetics and Cytogenetics, 1987
A probe derived from the 3' end of the CML breakpoint cluster region (bcr) was localized in chronic myelocytic leukemia (CML) cases with complex Philadelphia translocations, [t(8;9;22)(q13;q34;q11) and t(12;9;22)(p11;q34;q11)], and with "masked" Ph chromosomes, [t(9;5;22)(q34;q31;q11) and t(9;22)(q22;q34)], by a chromosomal in situ hybridization ...
Jacob M. Rowe, Kenneth B. Miller, Alan J. Kinniburgh, Junko H. Ohyashiki, Harvey D. Preisler, Azra Raza, Kazuma Ohyashiki, Avery A. Sandberg   +7 more
openaire   +3 more sources

Identification, molecular cloning, and characterization of the chromosome 12 breakpoint cluster region of uterine leiomyomas

Genes, Chromosomes and Cancer, 1994
AbstractRecent molecular cytogenetic analysis of uterine leiomyoma cell lines with chromosome 12 aberrations has indicated that their chromosome 12 breakpoints map between linkage locus D12S8 and the CHOP gene. Here, we report fluorescence in situ hybridization (FISH) and molecular cloning studies of the chromosome 12 breakpoints in a panel of seven ...
Jan M.W. Geurts, Patrick F.J. Kools, Herman Van den Berghe, Wim J.M. Van de Ven, Sabine Bartnitzke, Raf Mols, Eric F.P.M. Schoenmakers, S. Wanschura, Joern Bullerdiek   +8 more
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Cloning the breakpoint cluster region of the inv(16) in acute nonlymphocytic leukemia M4 Eo

Human Molecular Genetics, 1993
The pericentric inversion of chromosome 16 and the t(16;16) are two recurrent aberrations in bone marrow of patients with acute nonlymphocytic leukemia subtype M4 Eo, characterized by abnormal eosinophilic granulation. We describe here the precise localization of the breakpoints using fluorescence in situ hybridization (FISH) with cosmids spread over ...
J.G. Dauwerse, J.W. Wessels, R.H. Giles, J. Wiegant, B.A. van der Reijden, G. Fugazza, E.A. Jumelet, E. Smit, F. Baas, A.K. Raap, A. Hagemeijer, G.C. Baverstock, G.J.B. van Ommen, M.H. Breuning   +13 more
openaire   +3 more sources