Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85α subunit [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1996 Proteins such as the product of the break-point cluster region, chimaerin, and the Src homology 3-binding protein 3BP1, are GTPase activating proteins (GAPs) for members of the Rho subfamily of small GTP-binding proteins (G proteins or GTPases).
Andrea Musacchio +2 more
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DNA Cleavage within the MLL Breakpoint Cluster Region Is a Specific Event Which Occurs as Part of Higher-Order Chromatin Fragmentation during the Initial Stages of Apoptosis [PDF]
Molecular and Cellular Biology, 1997 Martin Stanulla +4 more
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Paternal origin of the rearranged major breakpoint cluster region in chronic myeloid leukemia [PDF]
Blood, 1994 Abstract The Philadelphia chromosome, t(9;22), is present in virtually all cases of chronic myeloid leukemia (CML). It has previously been shown by cytogenetic studies that the rearranged chromosome 22 in patients with CML is exclusively maternal in origin.
CE Litz, CM Copenhaver
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Breakpoint Cluster Region–Mediated Inflammation Is Dependent on Casein Kinase II [PDF]
The Journal of Immunology, 2016 Abstract The breakpoint cluster region (BCR) is known as a kinase and cause of leukemia upon fusing to Abl kinase. In this study, we demonstrate that BCR associated with the α subunit of casein kinase II (CK2α), rather than BCR itself, is required for inflammation development.
Jie Meng +16 more
semanticscholar +4 more sources
Nilotinib rapidly reverses breakpoint cluster region-Abelson oncogene fusion gene and M244V mutations in a patient with chronic myelogenous leukemia: A case report. [PDF]
Exp Ther Med, 2015 Shen X +5 more
europepmc +3 more sources
The Many Faces of Philadelphia: A Mature T-Cell Lymphoma with Variant Philadelphia-Translocation and Duplication of the Philadelphia Chromosome [PDF]
Hematology ReportsBackground: T-cell prolymphocytic leukemia (T-PLL) is a rare mature T-cell lymphoma that is usually associated with poor prognosis and short overall survival.
Livia Vida +4 more
doaj +2 more sources
Philadelphia-positive chronic myeloid leukemia with a chromosome 22 breakpoint outside the breakpoint cluster region [published erratum appears in Blood 1988 Jan;71(1):272] [PDF]
Blood, 1987 Abstract In chronic myelogenous leukemia (CML) the reciprocal translocation resulting in the Philadelphia chromosome (Ph1) leads to the formation of a chimeric transcriptional unit carrying both c-abl and bcr genetic information whose transcript is a new fused mRNA of 8.5-kilobases (kb) and whose translational product is a 210-kD ...
Licia Selleri +8 more
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Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3 [PDF]
Journal of Cell Science, 2004 Emily Malmberg +7 more
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Correction: Breakpoint Cluster Region–Mediated Inflammation Is Dependent on Casein Kinase II [PDF]
The Journal of Immunology, 2017 Meng Jie +16 more
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