Resistance to kinase inhibition through shortened target engagement
Molecular & Cellular Oncology, 2022 Imatinib, a selective inhibitor of the breakpoint cluster region (BCR)-ABL kinase, is the poster child for targeted cancer therapeutics. However, its efficacy is limited by resistance mutations.
Aziz M. Rangwala +4 more
doaj +1 more source
Statistics of Solar Wind Electron Breakpoint Energies Using Machine Learning Techniques [PDF]
, 2020 Solar wind electron velocity distributions at 1 au consist of a thermal "core" population and two suprathermal populations: "halo" and "strahl". The core and halo are quasi-isotropic, whereas the strahl typically travels radially outwards along the ...
Bakrania, Mayur R. +6 more
core +2 more sources
Cancer chromosome breakpoints cluster in gene‐rich genomic regions [PDF]
Genes, Chromosomes and Cancer, 2018 AbstractCancer cells are characterized by chromosome abnormalities, of which some, in particular balanced rearrangements, are associated with distinct tumor entities and/or with specific gene rearrangements that represent important steps in the carcinogenic process.
Felix Mitelman +4 more
openaire +2 more sources
Duplex DNA from Sites of Helicase-Polymerase Uncoupling Links Non-B DNA Structure Formation to Replicative Stress [PDF]
, 2020 BACKGROUND: Replication impediments can produce helicase-polymerase uncoupling allowing lagging strand synthesis to continue for as much as 6 kb from the site of the impediment.
Abdelhamid, Mahmoud A S +9 more
core +2 more sources
Breakpoint Cluster Region–Mediated Inflammation Is Dependent on Casein Kinase II [PDF]
The Journal of Immunology, 2016 Abstract The breakpoint cluster region (BCR) is known as a kinase and cause of leukemia upon fusing to Abl kinase. In this study, we demonstrate that BCR associated with the α subunit of casein kinase II (CK2α), rather than BCR itself, is required for inflammation development.
Jie Meng +16 more
openaire +2 more sources
DNA topoisomerases participate in fragility of the oncogene RET [PDF]
, 2013 Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under ...
A Ganguly +86 more
core +3 more sources
Myeloproliferative neoplasms and the JAK/STAT signaling pathway: an overview
Revista Brasileira de Hematologia e Hemoterapia, 2015 Myeloproliferative neoplasms are caused by a clonal proliferation of a hematopoietic progenitor. First described in 1951 as 'Myeloproliferative Diseases' and reevaluated by the World Health Organization classification system in 2011, myeloproliferative ...
Renata Mendes de Freitas +1 more
doaj +1 more source
Genome reorganization in different cancer types: detection of cancer specific breakpoint regions [PDF]
, 2019 Background: Tumorigenesis is a multi-step process which is accompanied by substantial changes in genome organization. The development of these changes is not only a random process, but rather comprise specific DNA regions that are prone to the ...
Klein, Andreas +3 more
core +1 more source
Identification of a novel long non-coding RNA within RUNX1 intron 5
Human Genomics, 2019 Background RUNX1 gene, a master regulator of the hematopoietic process, participates in pathological conditions as a partner for several genes in chromosomal translocations.
Nicolás Schnake +2 more
doaj +1 more source
BCR (breakpoint cluster region) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2010 Review on BCR (breakpoint cluster region), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire +2 more sources