Results 31 to 40 of about 160,061 (270)
Iraqi Journal of Hematology, 2023 BACKGROUND: Chronic myeloid leukemia (CML) has been well recognized as an exemplary instance of a malignant disease characterized by a distinctive molecular occurrence, namely the presence of the breakpoint cluster region (BCR)-c-ABL oncogene 1 (ABL1 ...
Aseel Majeed Hameed +3 more
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Radiology and Oncology, 2023 t(14;18)(q32;q21) translocation is an important genetic feature of follicular lymphoma resulting in antiapoptotic B-cell lymphoma 2 (BCL2) protein overexpression. On chromosome 18 breakpoint-site variation is high but does not affect BCL2.
Panjan Matej +4 more
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VNTR polymorphism in the breakpoint region of ABL1 and susceptibility to bladder cancer
BMC Medical Genomics, 2021 Background ABL1 is primarily known as a leukemia-related oncogene due to translocation, but about 2.2% of ABL1 mutations have been identified in bladder cancer, and high expression in solid cancer has also been detected.
Min-Hye Kim +8 more
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Cancer chromosome breakpoints cluster in gene‐rich genomic regions [PDF]
Genes, Chromosomes and Cancer, 2018 AbstractCancer cells are characterized by chromosome abnormalities, of which some, in particular balanced rearrangements, are associated with distinct tumor entities and/or with specific gene rearrangements that represent important steps in the carcinogenic process.
Felix Mitelman +4 more
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Resistance to kinase inhibition through shortened target engagement
Molecular & Cellular Oncology, 2022 Imatinib, a selective inhibitor of the breakpoint cluster region (BCR)-ABL kinase, is the poster child for targeted cancer therapeutics. However, its efficacy is limited by resistance mutations.
Aziz M. Rangwala +4 more
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PCR detection of a Maell polymorphism in the human major breakpoint cluster region (BCR) [PDF]
Nucleic Acids Research, 1991 J.S. McMlure, Craig E. Litz
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Aberrant methylation of the major breakpoint cluster region in chronic myeloid leukemia [PDF]
Blood, 1996 Isolated hypomethylated sites exist in the major breakpoint cluster region (M-bcr) where most Philadelphia chromosome (Ph) breakpoints are located. Twenty of 50 (40%) chronic myeloid leukemia (CML) patients were found to have aberrant hypermethylation of these sites on the rearranged M-bcr when compared with control marrows.
Cedith M. Copenhaver +2 more
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Myeloproliferative neoplasms and the JAK/STAT signaling pathway: an overview
Revista Brasileira de Hematologia e Hemoterapia, 2015 Myeloproliferative neoplasms are caused by a clonal proliferation of a hematopoietic progenitor. First described in 1951 as 'Myeloproliferative Diseases' and reevaluated by the World Health Organization classification system in 2011, myeloproliferative ...
Renata Mendes de Freitas +1 more
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BCR (breakpoint cluster region) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2010 Review on BCR (breakpoint cluster region), with data on DNA, on the protein encoded, and where the gene is implicated.
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