Results 41 to 50 of about 160,061 (270)

Identification of a novel long non-coding RNA within RUNX1 intron 5

Human Genomics, 2019
Background RUNX1 gene, a master regulator of the hematopoietic process, participates in pathological conditions as a partner for several genes in chromosomal translocations.
Nicolás Schnake, Marcela Hinojosa, Soraya Gutiérrez   +2 more
doaj   +1 more source

Presenilin 1 Regulates NF-κB Activation via Association with Breakpoint Cluster Region and Casein Kinase II

Journal of Immunology, 2018
We recently reported that NF-κB–mediated inflammation caused by breakpoint cluster region (BCR) is dependent on the α subunit of casein kinase II (CK2α) complex.
Yuki Tanaka, Lavannya Sabharwal, Mitsutoshi Ota, I. Nakagawa, Jing-Jing Jiang, Y. Arima, H. Ogura, M. Okochi, M. Ishii, D. Kamimura, M. Murakami   +10 more
semanticscholar   +1 more source

BCL6 alternative translocation breakpoint cluster region associated with follicular lymphoma grade 3B [PDF]

Genes, Chromosomes and Cancer, 2005
AbstractTranslocations involving band 3q27, affecting the major breakpoint region (MBR) of BCL6, are common in diffuse large B‐cell lymphomas (DLBCLs). Recent data suggest an alternative breakpoint cluster region (ABR) located between 245 and 285 kb 5′ of BCL6, which might be associated with Follicular Lymphoma (FL).
Anneke Bosga-Bouwer, Eugenia Haralambieva, Marije Booman, Ronald Boonstra, Anke van den Berg, Ed Schuuring, Eva van den Berg, Philip M. Kluin, Sibrand Poppema   +8 more
openalex   +5 more sources

Chromosome fragile sites in Arabidopsis harbor matrix attachment regions that may be associated with ancestral chromosome rearrangement events.

PLoS Genetics, 2012
Mutations in the BREVIPEDICELLUS (BP) gene of Arabidopsis thaliana condition a pleiotropic phenotype featuring defects in internode elongation, the homeotic conversion of internode to node tissue, and downward pointing flowers and pedicels.
Joelle S dela Paz, Patti E Stronghill, Scott J Douglas, Sandy Saravia, Clare A Hasenkampf, C Daniel Riggs   +5 more
doaj   +1 more source

Aphidicolin-Induced FRA3B Breakpoints Cluster in Two Distinct Regions

Genomics, 1997
The common fragile site at chromosomal band 3p14.2 (FRA3B) is the most sensitive single site in the human genome to induced chromosomal lesions. This fragile site may predispose chromosome 3p to breakage that is commonly observed in lung, renal, and many other cancers.
Ravi Shridhar, Rita Rosati, Liang Wang, David I. Smith, Thomas W. Glover, William Paradee, Chadwick Mullins, Charles M. Wilke   +7 more
openaire   +3 more sources

The two stem cell microRNA gene clusters C19MC and miR-371-3 are activated by specific chromosomal rearrangements in a subgroup of thyroid adenomas. [PDF]

PLoS ONE, 2010
Thyroid adenomas are common benign human tumors with a high prevalence of about 5% of the adult population even in iodine sufficient areas. Rearrangements of chromosomal band 19q13.4 represent a frequent clonal cytogenetic deviation in these tumors ...
Volkhard Rippe, Lea Dittberner, Verena N Lorenz, Norbert Drieschner, Rolf Nimzyk, Wolfgang Sendt, Klaus Junker, Gazanfer Belge, Jörn Bullerdiek   +8 more
doaj   +1 more source

Rare e14a3 (b3a3) BCR-ABL Fusion in Chronic Myeloid Leukemia in India: The Threats and Challenges in Monitoring Minimal Residual Disease (MRD)

Analytical Cellular Pathology, 2013
Objective: The primary objective of this work was to confirm the occurrence of rare BCR ABL fusion variant involving the a3 region of the ABL gene in a patient positive for t(9;22) translocation but negative for common major and minor breakpoint cluster ...
Salil Vaniawala, Arpan Acharya, Harsh Parekh, Pratap N. Mukhopadhyaya   +3 more
doaj   +1 more source

Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations

Case Reports in Hematology, 2019
We present a case report of a patient with acute myeloid leukemia (AML) characterized by the simultaneous presence of nucleophosmin 1 (NPM1) mutation and the breakpoint cluster region-Abelson (BCR-ABL) fusion oncogene.
Benedetta Mariotti, Federico Meconi, Raffaele Palmieri, Eleonora De Bellis, Serena Lavorgna, Tiziana Ottone, Vincenza Martini, Francesco Lo-Coco, Laura Cicconi   +8 more
doaj   +1 more source

Intracranial Hemorrhage Following Oral Low-Dose Methotrexate After Multiple Toxicities Caused by High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia

Frontiers in Pharmacology, 2019
An 11-year-old male patient with the deletion of IKZF1 (Ikaros family zinc finger 1) and positive Breakpoint Cluster Region-C-Abelson oncogene 1(BCR-ABL1) acute lymphoblastic leukemia developed mucositis, gastrointestinal toxicity, hepatotoxicity ...
Ning Xin, Zhou Fen, Cheng Li, Xiao Yan, Jin Runming   +4 more
doaj   +1 more source

Molecular characterization of the MLL-SEPT6 fusion gene in acute myeloid leukemia: identification of novel fusion transcripts and cloning of genomic breakpoint junctions

Haematologica, 2008
One of the MLL fusion partners in leukemia is the SEPT6 gene, which belongs to the evolutionarily conserved family of genes of septins. In this work we aimed to characterize at both the RNA and DNA levels three acute myeloid leukemias with cytogenetic ...
Nuno Cerveira, Francesca Micci, Joana Santos, Manuela Pinheiro, Cecília Correia, Susana Lisboa, Susana Bizarro, Lucília Norton, Anders Glomstein, Ann E. Åsberg, Sverre Heim, Manuel R. Teixeira   +11 more
doaj   +1 more source