Results 41 to 50 of about 32,784 (274)
Analytical Cellular Pathology, 2013 Objective: The primary objective of this work was to confirm the occurrence of rare BCR ABL fusion variant involving the a3 region of the ABL gene in a patient positive for t(9;22) translocation but negative for common major and minor breakpoint cluster ...
Salil Vaniawala +3 more
doaj +1 more source
The two stem cell microRNA gene clusters C19MC and miR-371-3 are activated by specific chromosomal rearrangements in a subgroup of thyroid adenomas. [PDF]
PLoS ONE, 2010 Thyroid adenomas are common benign human tumors with a high prevalence of about 5% of the adult population even in iodine sufficient areas. Rearrangements of chromosomal band 19q13.4 represent a frequent clonal cytogenetic deviation in these tumors ...
Volkhard Rippe +8 more
doaj +1 more source
Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations
Case Reports in Hematology, 2019 We present a case report of a patient with acute myeloid leukemia (AML) characterized by the simultaneous presence of nucleophosmin 1 (NPM1) mutation and the breakpoint cluster region-Abelson (BCR-ABL) fusion oncogene.
Benedetta Mariotti +8 more
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Haematologica, 2008 One of the MLL fusion partners in leukemia is the SEPT6 gene, which belongs to the evolutionarily conserved family of genes of septins. In this work we aimed to characterize at both the RNA and DNA levels three acute myeloid leukemias with cytogenetic ...
Nuno Cerveira +11 more
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A dual origin for Bcr-Abl gene translocation/fusion as dynamics of synergism of the hematopoietic stem cell and hemangioblast in chronic myeloid leukemia [PDF]
, 2015 Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic ...
Agius, Lawrence M.
core +1 more source
Frontiers in Pharmacology, 2019 An 11-year-old male patient with the deletion of IKZF1 (Ikaros family zinc finger 1) and positive Breakpoint Cluster Region-C-Abelson oncogene 1(BCR-ABL1) acute lymphoblastic leukemia developed mucositis, gastrointestinal toxicity, hepatotoxicity ...
Ning Xin +4 more
doaj +1 more source
Lazy Probabilistic Model Checking without Determinisation [PDF]
, 2015 The bottleneck in the quantitative analysis of Markov chains and Markov decision processes against specifications given in LTL or as some form of nondeterministic B\"uchi automata is the inclusion of a determinisation step of the automaton under ...
Hahn, Ernst Moritz +4 more
core +2 more sources
Tumor Biology, 2018 The Src homology-2 domain protein B is an adaptor protein operating downstream of tyrosine kinases. The Shb gene knockout has been found to accelerate p210 Breakpoint cluster region-cAbl oncogene 1 tyrosine kinase-induced leukemia.
Maria Jamalpour +4 more
doaj +1 more source
An integrated genomic and expression analysis of 7q deletion in splenic marginal zone lymphoma. [PDF]
PLoS ONE, 2012 Splenic marginal zone lymphoma (SMZL) is an indolent B-cell lymphoproliferative disorder characterised by 7q32 deletion, but the target genes of this deletion remain unknown.
A James Watkins +14 more
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Haemophagocytic syndrome triggered by acute lymphoblastic leukaemia with t(9;22)(p24; q11.2)
Journal of International Medical Research, 2020 Haemophagocytic syndrome (HPS) is a rare and potentially life-threatening condition that requires early diagnosis and prompt combined treatment. This case report describes a male patient with HPS, presenting as acute liver failure, that underwent a ...
Huiling Chen, Pengyun Zeng, Dekui Zhang
doaj +1 more source