Results 51 to 60 of about 160,061 (270)

An integrated genomic and expression analysis of 7q deletion in splenic marginal zone lymphoma. [PDF]

PLoS ONE, 2012
Splenic marginal zone lymphoma (SMZL) is an indolent B-cell lymphoproliferative disorder characterised by 7q32 deletion, but the target genes of this deletion remain unknown.
A James Watkins, Rifat A Hamoudi, Naiyan Zeng, Qingguo Yan, Yuanxue Huang, Hongxiang Liu, Jianzhong Zhang, Esteban Braggio, Rafael Fonseca, Laurence de Leval, Peter G Isaacson, Andrew Wotherspoon, Ellen D McPhail, Ahmet Dogan, Ming-Qing Du   +14 more
doaj   +1 more source

Disparate effects of gene deficiency on disease characteristics in murine models of myeloid, B-cell, and T-cell leukemia

Tumor Biology, 2018
The Src homology-2 domain protein B is an adaptor protein operating downstream of tyrosine kinases. The Shb gene knockout has been found to accelerate p210 Breakpoint cluster region-cAbl oncogene 1 tyrosine kinase-induced leukemia.
Maria Jamalpour, Xiujuan Li, Karin Gustafsson, Jeffrey W Tyner, Michael Welsh   +4 more
doaj   +1 more source

SRBreak: A read-depth and split-read framework to identify breakpoints of different events inside simple copy-number variable regions

Frontiers in Genetics, 2016
Copy-number variation (CNV) has been associated with increased risk of complex diseases. High throughput sequencing (HTS) technologies facilitate the detection of copy-number variable regions (CNVRs) and their breakpoints.
HOANG T NGUYEN, HOANG T NGUYEN, HOANG T NGUYEN, HOANG T NGUYEN, James Boocock, James Boocock, James Boocock, Tony R Merriman, Tony R Merriman, Mik A Black, Mik A Black   +10 more
doaj   +1 more source

Haemophagocytic syndrome triggered by acute lymphoblastic leukaemia with t(9;22)(p24; q11.2)

Journal of International Medical Research, 2020
Haemophagocytic syndrome (HPS) is a rare and potentially life-threatening condition that requires early diagnosis and prompt combined treatment. This case report describes a male patient with HPS, presenting as acute liver failure, that underwent a ...
Huiling Chen, Pengyun Zeng, Dekui Zhang
doaj   +1 more source

Genomic EWS-FLI1 fusion sequences in Ewing sarcoma resemble breakpoint characteristics of immature lymphoid malignancies. [PDF]

PLoS ONE, 2013
Chromosomal translocations between the EWS gene and members of the ETS gene family are characteristic molecular features of the Ewing sarcoma. The most common translocation t(11;22)(q24;q12) fuses the EWS gene to FLI1, and is present in 85-90% of Ewing ...
Manfred Berger, Uta Dirksen, Andreas Braeuninger, Gabriele Koehler, Heribert Juergens, Manuela Krumbholz, Markus Metzler   +6 more
doaj   +1 more source

Update in Childhood Chronic Myeloid Leukemia

Hemato, 2022
Chronic myeloid leukemia (CML) in childhood represents only 3% of newly diagnosed pediatric leukemia. The diagnostic hallmark of CML is the Philadelphia (Ph) chromosome, which derives from the fusion of the ABL1-oncogene located on chromosome 9 to the ...
Fiorina Giona, Simona Bianchi
doaj   +1 more source

Impact of charged particle exposure on homologous DNA double-strand break repair in human blood-derived cells

Frontiers in Oncology, 2015
Ionizing radiation generates DNA double-strand breaks (DSB) which, unless faithfully repaired, can generate chromosomal rearrangements in hematopoietic stem and/or progenitor cells (HSPC), potentially priming the cells towards a leukemic phenotype. Using
Melanie eRall, Daniela eKraft, Meta eVolcic, Aljona eCucu, Elena eNasonova, Gisela eTaucher-Scholz, Halvard eBönig, Lisa eWiesmüller, Claudia eFournier   +8 more
doaj   +1 more source

Dasatinib‐induced chylothorax in a patient with chronic myeloid leukaemia: a case report and literature review

Respirology Case Reports, 2021
Dasatinib is a potent and effective second‐generation oral tyrosine kinase inhibitor that is clinically indicated for the treatment of imatinib‐resistant or imatinib‐intolerant breakpoint cluster region‐Abelson (BCR‐ABL)‐positive chronic myeloid ...
Chao‐Chin Hsu, Jui‐Feng Hsu, Kuan‐Li Wu   +2 more
doaj   +1 more source

High cell density and latent membrane protein 1 expression induce cleavage of the mixed lineage leukemia gene at 11q23 in nasopharyngeal carcinoma cell line

Journal of Biomedical Science, 2010
Background Nasopharyngeal carcinoma (NPC) is commonly found in Southern China and South East Asia. Epstein-Barr virus (EBV) infection is well associated with NPC and has been implicated in its pathogenesis.
Sim Sai-Peng, Yee Peter
doaj   +1 more source

Analysis of meiotic recombination in 22q11.2, a region that frequently undergoes deletions and duplications

BMC Medical Genetics, 2007
Background The 22q11.2 deletion syndrome is the most frequent genomic disorder with an estimated frequency of 1/4000 live births. The majority of patients (90%) have the same deletion of 3 Mb (Typically Deleted Region, TDR) that results from aberrant ...
Heine-Suñer Damià, Fibla Joan, Sánchez-de-la-Torre Manuel, Rosell Jordi, Torres-Juan Laura   +4 more
doaj   +1 more source