Results 61 to 70 of about 32,784 (274)

Characteristics of BCR–ABL gene variants in patients of chronic myeloid leukemia

Open Medicine, 2021
Depending on breakpoints of rearrangement different types of BCR–ABL fusion protein can be generated in patients of chronic myeloid leukemia (CML).
Amin Huma, Ahmed Suhaib
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Analysis of meiotic recombination in 22q11.2, a region that frequently undergoes deletions and duplications

BMC Medical Genetics, 2007
Background The 22q11.2 deletion syndrome is the most frequent genomic disorder with an estimated frequency of 1/4000 live births. The majority of patients (90%) have the same deletion of 3 Mb (Typically Deleted Region, TDR) that results from aberrant ...
Heine-Suñer Damià, Fibla Joan, Sánchez-de-la-Torre Manuel, Rosell Jordi, Torres-Juan Laura   +4 more
doaj   +1 more source

Bayesian modeling of recombination events in bacterial populations [PDF]

, 2008
Background: We consider the discovery of recombinant segments jointly with their origins within multilocus DNA sequences from bacteria representing heterogeneous populations of fairly closely related species.
A Baldwin, A Baldwin, A Baldwin, A Rambaut, A Skalka, Adam Baldwin, C Fraser, Chris Dowson, CP Robert, CX Chan, D Falush, D Husmeier, D Posada, DJ Hand, E Mahenthiralingam, E Mahenthiralingam, EHL Aarts, Eshwar Mahenthiralingam, FM Cohan, J Corander, J Corander, J Corander, J Corander, J Felsenstein, J Hein, J Maynard Smith, JG Lawrence, JS Sinsheimer, Jukka Corander, JV Braun, M Arenas, M Hasegawa, MA Suchard, MJ Schervish, NC Grassly, P Marttinen, Pekka Marttinen, R Jain, RA Elton, S Sawyer, SA Sisson, VN Minin, VN Minin, William P Hanage, WJ Wiersinga, WP Hanage, X Didelot   +46 more
core   +5 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A methodology for the capture and analysis of hybrid data: a case study of program debugging [PDF]

, 2007
No description ...
A. F. Blackwell, A. R. Jansen, B. Boulay du, Benedict du Boulay, D. Bergantz, D. J. Gilmore, D. J. Gilmore, D. Kranzlmüller, D. T. Hountalas, F. Détienne, F. Gabbay, G. Friedrich, I. Vessey, I. Vessey, K. Stenning, M. Crosby, M. J. Patel, M. T. H. Chi, N. K. Denzin, N. Pennington, N. Pennington, P. Mulholland, P. Romero, P. Romero, P. Romero, Pablo Romero, R. Cox, R. Cox, R. Cox, R. Marzi, Richard Cox, Rudi Lutz, S. Ainsworth, S. P. Davies, S. P. Robertson, Sallyann Bryant, T. Jong de, Y. Papadopoulos   +37 more
core   +1 more source

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou, Carl D. Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N. Kimball, Chen Bowang, Hyacinth I. Hyacinth, Jonathan Rosand, Christopher D. Anderson, Caspar Grond‐Ginsbach, Daniel Woo, Stacie L. Demel   +12 more
wiley   +1 more source

On the numerical stability of Fourier extensions [PDF]

, 2012
An effective means to approximate an analytic, nonperiodic function on a bounded interval is by using a Fourier series on a larger domain. When constructed appropriately, this so-called Fourier extension is known to converge geometrically fast in the ...
Ben Adcock, Ben Adcock, Ben Adcock, Daan Huybrechs, Daan Huybrechs, Daan Huybrechs, Jesús Martín–vaquero, Jesús Martín–vaquero   +7 more
core   +1 more source

Scientific Objectives for UV/Visible Astrophysics Investigations: A Summary of Responses by the Community (2012) [PDF]

, 2013
Following several recommendations presented by the Astrophysics Decadal Survey 2010 centered around the need to define "a future ultraviolet-optical space capability," on 2012 May 25, NASA issued a Request for Information (RFI) seeking persuasive ...
Benford, Dominic J., Neff, Susan G., Perez, Mario R., Scowen, Paul A.   +3 more
core   +5 more sources