Results 71 to 80 of about 32,784 (274)

Structural Variation and 3D Genome‐Driven DNA/RNA Methylation Divergence Contributing to Cotton Fiber Domestication

Advanced Science, EarlyView.
These findings elucidated the crucial role of the “SVs‐3D genome remodeling‐epigenetic modifications‐gene expression” cascade regulatory network in cotton fiber domestication, offering both a theoretical foundation and genetic resources for molecular design breeding in fiber crops.
Lei Shao, Shangkun Jin, Haojie Jiang, Tianyu Pan, Zesheng Rui, Xiaowen Shi, Ting Zhao, Zhanfeng Si, Xueying Guan, Yan Hu, Tianzhen Zhang, Lei Fang   +11 more
wiley   +1 more source

A novel three-colour fluorescence in situ hybridization approach for the detection of t(7;12)(q36;p13) in acute myeloid leukaemia reveals new cryptic three way translocation t(7;12;16) [PDF]

, 2013
© 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).The t(7;12)(q36;p13 ...
Abdulbasit Naiel, Andreasson, Beverloo, Cho, Elena Fleischman, Grigory Tsaur, Hollington, Jochen Harbott, Michael Vetter, Olga Plekhanova, Olga Sokova, Raimondi, Sabrina Tosi, Wildenhain, Wlodarska   +14 more
core   +2 more sources

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science, EarlyView.
We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
wiley   +1 more source

Estimation of the difference in HbF expression due to loss of the 5' δ-globin BCL11A binding region

Haematologica, 2013
BCL11A was the focus of recent studies on its inhibiting effect when bound onto the β-globin cluster in the mechanism of hemoglobin switching and HbF downregulation.
Elyes Slim Ghedira, Laure Lecerf, Emmanuelle Faubert, Bruno Costes, Kamran Moradkhani, Dora Bachir, Frédéric Galactéros, Serge Pissard   +7 more
doaj   +1 more source

Theory of site-disordered magnets

, 1998
In realistic spinglasses, such as CuMn, AuFe and EuSrS, magnetic atoms are located at random positions. Their couplings are determined by their relative positions. For such systems a field theory is formulated.
Nieuwenhuizen, Th. M., van Duin, C. N. A.   +1 more
core   +1 more source

Change-point model on nonhomogeneous Poisson processes with application in copy number profiling by next-generation DNA sequencing [PDF]

, 2012
We propose a flexible change-point model for inhomogeneous Poisson Processes, which arise naturally from next-generation DNA sequencing, and derive score and generalized likelihood statistics for shifts in intensity functions.
Shen, Jeremy J., Zhang, Nancy R.
core   +3 more sources

Reference‐Guided Chromosome‐by‐Chromosome de novo Assembly at Scale Using Low‐Coverage High‐Fidelity Long‐Reads with HiFiCCL

Advanced Science, EarlyView.
HiFiCCL, as the first assembly framework specifically designed for low‐coverage high‐fidelity reads, improves the assembly quality of existing assemblers and also enhances downstream applications such as large structural variant (SV) detection (>10 000 bp), synteny analysis, pangenome graph construction, and graph‐based individual‐specific germline SVs
Zhongjun Jiang, Weihua Pan, Runtian Gao, Heng Hu, Wentao Gao, Murong Zhou, Yu‐Hang Yin, Zhipeng Qian, Shuilin Jin, Guohua Wang   +9 more
wiley   +1 more source

IKZF1 Deletions with COBL Breakpoints Are Not Driven by RAG-Mediated Recombination Events in Acute Lymphoblastic Leukemia [PDF]

, 2019
IKZF1 deletion (ΔIKZF1) is an important predictor of relapse in both childhood and adult B-cell precursor acute lymphoblastic leukemia (B-ALL). Previously, we revealed that COBL is a hotspot for breakpoints in leukemia and could promote IKZF1 deletions ...
Alonso, Cristina N., Bakhshi, Sameer, Barbosa, Thayana C., Bashton, Matthew, Cazzaniga, Gianni, Duployez, Nicolas, Emerenciano, Mariana, Gupta, Sanjeev K., Harrison, Christine J., Horstmann, Martin, Lopes, Bruno A., Mansur, Marcela B., Marschalek, Rolf, Meyer, Claus, Palmi, Chiara, Pombo-de-Oliveira, Maria S., Poubel, Caroline P., Sutton, Rosemary, Tsaur, Grigory, Venn, Nicola C., zur Stadt, Udo   +20 more
core   +1 more source

Genomic Structural Variations Provide Insights Into Litter Size and Teat Number Traits in Hu Sheep

Animal Research and One Health, EarlyView.
Here, we conducted whole genome sequencing on 300 Hu sheep with an average depth of 16.51X. Two candidate genes associated with litter size and teat number traits were identified, namely MAST2 and AFDN. ABSTRACT Litter size and the teat number are important economic indicators in sheep production.
Xin Xiang, Wei Dai, Jiqiang Liu, Zhengguang Wang   +3 more
wiley   +1 more source

Modeling the evolution space of breakage fusion bridge cycles with a stochastic folding process [PDF]

, 2015
Breakage-Fusion-Bridge cycles in cancer arise when a broken segment of DNA is duplicated and an end from each copy joined together. This structure then 'unfolds' into a new piece of palindromic DNA.
B McClintock, BJ Raphael, BJ Raphael, C Alkan, C Lemaitre, C Xie, C. D. Greenman, CD Greenman, CD Greenman, D Sankoff, ED Pleasance, ED Pleasance, G Klambauer, GR Bignell, GR Bignell, J Neggers, J. Marshall, JL Bentley, M Kinsella, M. R. Stratton, P Loo Van, P. J. Campbell, PJ Campbell, S Zakov, S. L. Cooke   +24 more
core   +2 more sources