Results 21 to 30 of about 7,353,326 (373)

Comprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilities

Cell Discovery, 2023
Germline-somatic mutation interactions are universal and associated with tumorigenesis, but their role in breast cancer, especially in non-Caucasians, remains poorly characterized. We performed large-scale prospective targeted sequencing of matched tumor-
Chao Chen, Cai-Jin Lin, Yu-Chen Pei, Ding Ma, Li Liao, Si-Yuan Li, Lei Fan, Gen-Hong Di, Song-Yang Wu, Xi-Yu Liu, Yun-Jin Wang, Qi Hong, Guo-Liang Zhang, Lin-Lin Xu, Bei-Bei Li, Wei Huang, Jin-Xiu Shi, Yi-Zhou Jiang, Xin Hu, Zhi-Ming Shao   +19 more
doaj   +1 more source

Global patterns of breast cancer incidence and mortality: A population‐based cancer registry data analysis from 2000 to 2020

Cancer Communications, 2021
Breast cancer is the most commonly diagnosed cancer and leading cause of cancer death among women worldwide but has patterns and trends which vary in different countries.
S. Lei, R. Zheng, Siwei Zhang, Shaoming Wang, Ru Chen, K. Sun, H. Zeng, Jiachen Zhou, Wenqiang Wei   +8 more
semanticscholar   +1 more source

Dalpiciclib and pyrotinib in women with HER2-positive advanced breast cancer: a single-arm phase II trial

Nature Communications, 2023
CDK4/6 inhibitors have shown a synergistic effect with anti-HER2 therapy in hormone receptor (HR)-positive and HER2-positive breast cancer (BC). In this phase 2 study (NCT04293276), we aim to evaluate a dual-oral regimen of CDK4/6 inhibitor dalpiciclib ...
Min Yan, Limin Niu, Huimin Lv, Mengwei Zhang, Jing Wang, Zhenzhen Liu, Xiuchun Chen, Zhenduo Lu, Chongjian Zhang, Huiai Zeng, Shengnan Zhao, Yajing Feng, Huihui Sun, Huajun Li   +13 more
doaj   +1 more source

Understanding breast cancer as a global health concern

British Journal of Radiology, 2021
Breast cancer is now the most commonly diagnosed cancer in the world. The most recent global cancer burden figures estimate that there were 2.26 million incident breast cancer cases in 2020 and the disease is the leading cause of cancer mortality in ...
L. Wilkinson, T. Gathani
semanticscholar   +1 more source

Comparison of survival in non-metastatic inflammatory and other T4 breast cancers: a SEER population-based analysis

BMC Cancer, 2021
Background Previous studies have reported poor survival rates in inflammatory breast cancer (IBC) patients than non-inflammatory local advanced breast cancer (non-IBC) patients.
Dechuang Jiao, Jingyang Zhang, Jiujun Zhu, Xuhui Guo, Yue Yang, Hui Xiao, Zhenzhen Liu   +6 more
doaj   +1 more source

Pembrolizumab for Early Triple-Negative Breast Cancer.

New England Journal of Medicine, 2020
BACKGROUND Previous trials showed promising antitumor activity and an acceptable safety profile associated with pembrolizumab in patients with early triple-negative breast cancer.
P. Schmid, J. Cortés, L. Pusztai, H. McArthur, S. Kümmel, J. Bergh, C. Denkert, Yeon-Hee Park, R. Hui, N. Harbeck, M. Takahashi, T. Foukakis, P. Fasching, F. Cardoso, M. Untch, L. Jia, V. Karantza, J. Zhao, G. Aktan, R. Dent, J. O’Shaughnessy   +20 more
semanticscholar   +1 more source

A Population-Based Study of Genes Previously Implicated in Breast Cancer.

New England Journal of Medicine, 2021
BACKGROUND Population-based estimates of the risk of breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for risk assessment and management in women with inherited pathogenic variants ...
Chunling Hu, S. Hart, Rohan D Gnanaolivu, Hongyan Huang, Kun Y. Lee, Jie Na, Chi Gao, J. Lilyquist, S. Yadav, N. Boddicker, R. Samara, J. Klebba, C. Ambrosone, H. Anton-Culver, P. Auer, E. Bandera, L. Bernstein, K. Bertrand, E. Burnside, B. Carter, Heather Eliassen, S. Gapstur, M. Gaudet, C. Haiman, James M. Hodge, D. Hunter, E. Jacobs, E. John, C. Kooperberg, A. Kurian, L. Le Marchand, S. Lindstroem, Tricia Lindstrom, Huiyan Ma, S. Neuhausen, P. Newcomb, K. O’Brien, J. Olson, I. Ong, T. Pal, J. Palmer, Alpa V. Patel, S. Reid, L. Rosenberg, D. Sandler, Christopher Scott, R. Tamimi, Jack A. Taylor, A. Trentham-Dietz, C. Vachon, C. Weinberg, S. Yao, A. Ziogas, J. Weitzel, D. Goldgar, S. Domchek, K. Nathanson, P. Kraft, E. Polley, F. Couch   +59 more
semanticscholar   +1 more source

Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women. [PDF]

, 2013
BackgroundVitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). Although African-Americans have the lowest levels of serum vitamin D, there is a dearth of information on VDR gene polymorphisms and breast cancer among
Chen, Zujian, Heber, David, Koeffler, H Phillip, Mishra, Dhruva K, Ong, May, Sarkissyan, Marianna, Sarkissyan, Suren, Shang, Xiying, Vadgama, Jaydutt V, Wu, Yanyuan   +9 more
core   +10 more sources

A family history of breast cancer will not predict female early onset breast cancer in a population-based setting [PDF]

, 2008
: BACKGROUND: An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening.
A Lucassen, A Ziogras, AE Guttmacher, Caroline Seynaeve, Catharina E Jacobi, Cecile TM Brekelmans, Cees J Cornelisse, Christi J van Asperen, CJ Van Asperen, CJ Van Asperen, Collaborative Group on Hormonal Factors in Breast Cancer, D Ford, D Steinmann, D Thompson, DA Berry, DM Eccles, DM Eccles, EB Claus, EB Claus, Elly MM Krol-Warmerdam, FE Harrell Jr, G Parmigiani, Geertruida H de Bock, H Eerola, Jan GM Klijn, Jannet Blom, Johannes C van Houwelingen, JP Klein, KF Hoskins, KL Nathanson, O Visser, PD Pharoah, Peter Devilee, R Gershoni-Baruch, Rob AEM Tollenaar, RW Blamey, The Breast Cancer Linkage Consortium   +36 more
core   +7 more sources

Triple-negative breast cancer molecular subtyping and treatment progress

Breast Cancer Research, 2020
Triple-negative breast cancer (TNBC), a specific subtype of breast cancer that does not express estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2 (HER-2), has clinical features that include high invasiveness,
Li Yin, Jiang-jie Duan, X. Bian, Shi-cang Yu   +3 more
semanticscholar   +1 more source