Results 61 to 70 of about 7,353,326 (373)

Single-dose trastuzumab monotherapy achieved pathological complete response (pCR) in a patient with HER2-positive breast cancer: a case report

Surgical Case Reports, 2023
Background With advances in breast cancer treatment, the importance of de-escalation therapy to reduce harm during the treatment of elderly patients has attracted attention in recent years.
Ayaka Isogai, Haruru Kotani, Masataka Sawaki, Masaya Hattori, Akiyo Yoshimura, Ayumi Kataoka, Kazuki Nozawa, Yuri Ozaki, Yuka Endo, Akira Nakakami, Rie Komaki, Hiroji Iwata   +11 more
doaj   +1 more source

Premenopausal endogenous oestrogen levels and breast cancer risk: a meta-analysis. [PDF]

, 2011
BACKGROUND: Many of the established risk factors for breast cancer implicate circulating hormone levels in the aetiology of the disease. Increased levels of postmenopausal endogenous oestradiol (E2) have been found to increase the risk of breast cancer ...
AH Eliassen, C Frost, CR Rosenberg, D J Bratton, DJ Hand, DK Wysowski, EW Steyerberg, G Chene, HV Thomas, J Russo, JN Matthews, JP Costantino, JTCB Herjan, K Tanabe, K Walker, K Walker, KJ Helzlsouer, LJ Martin, M Kabuto, MC Pike, MH Gail, N Vasiljevic, R DerSimonian, R Kaaks, RC Travis, RF Galbraith, S Greenland, SA Missmer, The Endogenous Hormones and Breast cancer Collaborative Group, TJ Key   +29 more
core   +1 more source

Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Ca
This article presents global cancer statistics by world region for the year 2022 based on updated estimates from the International Agency for Research on Cancer (IARC).
F. Bray, M. Laversanne, Hyuna Sung, J. Ferlay, R. Siegel, Isabelle Soerjomataram, A. Jemal   +6 more
semanticscholar   +1 more source

The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression. [PDF]

, 2016
Molecular classification of cancers into subtypes has resulted in an advance in our understanding of tumour biology and treatment response across multiple tumour types. However, to date, cancer profiling has largely focused on protein-coding genes, which
Backofen, Rolf, Cao, Xuhong, Chinnaiyan, Arul M, Collins, Colin, Feng, Felix Y, Gawronski, Alexander, Han, Sumin, Hayes, Daniel F, Hosono, Yasuyuki, Iyer, Matthew K, Kregel, Steven, Ma, Teng, Malik, Rohit, Niknafs, Yashar S, Pierce, Lori J, Pitchiaya, Sethuramasundaram, Poliakov, Anton, Prensner, John R, Rae, James M, Sahinalp, Cenk S, Siebenaler, Ronald F, Singhal, Udit, Speers, Corey, Uhl, Michael, Wilder-Romans, Kari, Xiao, Lanbo, Zhang, Chao, Zhao, Shuang G   +27 more
core   +1 more source

Risk of ischemic heart disease in women after radiotherapy for breast cancer.

New England Journal of Medicine, 2013
BACKGROUND Radiotherapy for breast cancer often involves some incidental exposure of the heart to ionizing radiation. The effect of this exposure on the subsequent risk of ischemic heart disease is uncertain.
S. Darby, M. Ewertz, P. Mcgale, A. Bennet, U. Blom-Goldman, D. Brønnum, C. Correa, D. Cutter, Giovanna Gagliardi, B. Gigante, M. Jensen, A. Nisbet, R. Peto, K. Rahimi, Carolyn Taylor, P. Hall   +15 more
semanticscholar   +1 more source

Clinical significance of HER2-low expression in early breast cancer: a nationwide study from the Korean Breast Cancer Society

Breast Cancer Research, 2022
There is an increasing interest in HER2-low breast cancer with promising data from clinical trials using novel anti-HER2 antibody–drug conjugates. We explored the differences in clinicopathological characteristics and survival outcomes between HER2-low ...
H. Won, J. Ahn, Y. Kim, Jin Sung Kim, J. Song, Hong-Kyu Kim, Jeeyeon Lee, H. Park, Yong-Seok Kim   +8 more
semanticscholar   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer

Nature Communications, 2018
Triple negative breast cancers harbor multiple copy number aberrations driving gene expression changes thought to underpin their malignant phenotypes. Here the authors integrate these features, finding and functionally validating 37 gene addictions among
Nirmesh Patel, Daniel Weekes, Konstantinos Drosopoulos, Patrycja Gazinska, Elodie Noel, Mamun Rashid, Hasan Mirza, Jelmar Quist, Fara Brasó-Maristany, Sumi Mathew, Riccardo Ferro, Ana Mendes Pereira, Cynthia Prince, Farzana Noor, Erika Francesch-Domenech, Rebecca Marlow, Emanuele de Rinaldis, Anita Grigoriadis, Spiros Linardopoulos, Pierfrancesco Marra, Andrew N. J. Tutt   +20 more
doaj   +1 more source

Effects of reproductive and demographic changes on breast cancer incidence in China: A modeling analysis [PDF]

, 2008
Background: Breast cancer incidence is currently low in China. However, the distribution of reproductive and lifestyle risk factors for breast cancer among Chinese women is changing rapidly.
Colditz, Graham A., Gao, Yu-Tang, Hesketh, Therese, Linos, Eleni, Linos, Katerina, Qu, Jian Ding, Rosner, Bernard A., Spanos, Demetri, Zheng, Wei   +8 more
core   +1 more source

A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.

New England Journal of Medicine, 2004
BACKGROUND The likelihood of distant recurrence in patients with breast cancer who have no involved lymph nodes and estrogen-receptor-positive tumors is poorly defined by clinical and histopathological measures. METHODS We tested whether the results of
S. Paik, S. Shak, G. Tang, Chungyeul Kim, J. Baker, M. Cronin, F. Baehner, M. Walker, D. Watson, T. Park, W. Hiller, E. Fisher, D. Wickerham, J. Bryant, N. Wolmark, Genomic Health, Redwood City, S. Francisco   +17 more
semanticscholar   +1 more source