Results 211 to 220 of about 9,188,168 (301)

Healthcare professional perspectives on hereditary breast cancer risk assessment prior to gender-affirming mastectomy. [PDF]

Breast Cancer Res Treat
Zayhowski K, Blumen K, Mittendorf KF, Pratt R, Berro T, Streed C, MacFarlane IM.   +6 more
europepmc   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Performance of clinical breast cancer risk prediction models vs a mammography-based artificial intelligence risk model. [PDF]

J Natl Cancer Inst
Kaul M, Scott CG, Wadzinske A, Banerjee I, Hursh D, Norman A, Wu FF, Correa-Medero R, Couch F, Pruthi S, Kontos D, McCarthy AM, Olson J, Winham S, Kerlikowske K, Vachon CM.   +15 more
europepmc   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Obesity and Age Elevate Tissue-Resident Microbiota Akkermansia muciniphila to Induce Oxidative Stress and Promote Breast Cancer Risk. [PDF]

Cancer Res
Clear KYJ, Arnone AA, Tsai YT, Wilson AS, Carneiro Buchele ML, Furdui CM, Howard-McNatt M, Chiba A, Soto-Pantoja DR, Tooze JA, Peoples A, Duet ML, Katz AJ, Giri DD, Iyengar NM, Cook KL.   +15 more
europepmc   +1 more source

Immunomagnetic‐MXene Bifunctional Probes for Ultrasensitive and Specific Terahertz Metasensing of Tumor‐Derived Exosomes

Advanced Science, EarlyView.
An immunomagnetic‐MXene bifunctional probe integrated with THz metamaterials enables ultrasensitive and specific detection of pancreatic cancer‐derived exosomes. Dual biomarker recognition ensures high specificity, while MXene signal amplification achieves a detection limit of 647 particles mL−1.
Weidong Jin, Jiyue Chen, Fengxin Xie, Huiyan Tian, Xuechen Dou, Yanqi Han, Lu Zhang, Jining Li, Xiang Yang   +8 more
wiley   +1 more source

A Comparative Species Framework to Identify Candidate Salivary miRNAs Associated with Breast Cancer Risk. [PDF]

Int J Mol Sci
Miller JL, DaCosta M, Bakhle KM, Lai L, Post DE, Harman RM, Van de Walle GR.   +6 more
europepmc   +1 more source

Intermittent Fasting Reduces Taurine Availability and Promotes Antitumor Immunity Through PERK Attenuation‐Associated Paraptosis‐Like Cell Death in Colorectal Cancer

Advanced Science, EarlyView.
This study identifies reduced taurine availability as a mediator of intermittent fasting in colorectal cancer and shows that taurine interacts with GRP78 to maintain PERK abundance post‐transcriptionally. It further shows that taurine depletion destabilizes PERK, induces immunogenic paraptosis, remodels the tumor microenvironment toward a CD8+ T cell ...
Baohui Song, Sikei Kam, Jingyi Liu, Rui Lv, Xucheng Huo, Zhanghan Chen, Yuelun Dong, Shilun Cai, Bing Li, Ruobing Ren, Yunshi Zhong, Mingyan Cai   +11 more
wiley   +1 more source