Results 41 to 50 of about 5,162,410 (252)

Breast Conservation Surgery: State of the Art

International Journal of Breast Cancer, 2011
Breast conservation surgery is available to the vast majority of women with breast cancer. The combination of neoadjuvant therapies and oncoplastic surgical techniques allows even large tumours to be managed with a breast-conserving approach.
Jonathan White, Raj Achuthan, Philip Turton, Mark Lansdown   +3 more
doaj   +1 more source

Radiological Evaluation of Pregnancy Associated Breast Carcinoma: A Retrospective Study

International Journal of Anatomy Radiology and Surgery, 2019
Introduction: Pregnancy-Associated Breast Cancer (PABC) is any breast cancer diagnosed during pregnancy or within 12 months after delivery. PABC is a rare, having an incidence of approximately 0.3/1000 pregnancies, however it’s incidence is increasing as
Aakriti Kapoor, Anjum Syed, Bina Ravi, Shalinee Rao, Manoj Gupta, Surabhi Mehrotra, Divya Pandey, Priyanka Gupta   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

CEM immediately after contrast-enhanced CT: a one-step staging of breast cancer

European Radiology Experimental
Background Contrast-enhanced mammography (CEM) is a promising technique. We evaluated the diagnostic potential of CEM performed immediately after contrast-enhanced computed tomography (CE-CT).
Antonietta Ancona, Michele Telegrafo, Rita Roberta Fella, Donato Iamele, Sebastiano Cantore, Marco Moschetta   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Analysis of Home Care Supports Funded by the HSE 2008–2016 [PDF]

, 2016
This paper seeks to summarise the situation of publicly funded home care over the period 2008- 2016. Of particular interest is the overall change to the level of resources being directed to home care in the 2016 HSE Service Plan, in particular the actual
Care Alliance Ireland
core  

The impact of hsa-miR-1972 on the expression of von Willebrand factor in breast cancer progression regulation [PDF]

PeerJ
Background Breast cancer (BC) is one of most frequent female malignancies that poses multiple challenges in treatment and prevention. This study aimed to explore the role of miRNAs and their target genes during the BC progression. Methods Based on the BC
Changjiang Yu, Tao Zhang, Fan Chen, Zhenyang Yu   +3 more
doaj   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The oncogenic role of TIMM8A in cancer and the mechanistic insights into the function in breast cancer cells

Scientific Reports
The expression of TIMM8A, a molecular chaperone involved in mitochondrial protein translocation, was observed to be significantly elevated in various tumor types.
Weiwei Wang, Mengjie Liu, Huizi Wu, Jia Li, Wei Lv, Chaofan Li, Chong Du, Cong Feng, Yu Zhang, Yifan Cai, Yiwei Jia, Yijian Hu, Jingkun Qu, Shuqun Zhang, Fei Wu   +14 more
doaj   +1 more source