Results 21 to 30 of about 2,027 (134)

Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer [PDF]

, 2010
Introduction In breast cancer, gene expression analyses have defined five tumor subtypes (luminal A, luminal B, HER2-enriched, basal-like and claudin-low), each of which has unique biologic and prognostic features.
Aleix Prat, Joel S Parker, Olga Karginova, Cheng Fan, Chad Livasy, Jason I Herschkowitz, Xiaping He, Charles M Perou   +7 more
core   +2 more sources

Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro [PDF]

, 2010
Introduction: The homeobox-containing transcription factor muscle segment homeobox 2 (Msx2) plays an important role in mammary gland development. However, the clinical implications of Msx2 expression in breast cancer are unclear.
Lanigan, Fiona, Gremel, Gabriela, Hughes, Rowena, Brennan, Donal J., Martin, Finian, Jirström, Karin,, Gallagher, William M., Lund University.   +7 more
core   +2 more sources

Microcalcifications in breast cancer: novel insights into the molecular mechanism and functional consequence of mammary mineralisation. [PDF]

, 2012
BACKGROUND: Mammographic microcalcifications represent one of the most reliable features of nonpalpable breast cancer yet remain largely unexplored and poorly understood.
A Bellahcene, A Bellahcene, A Gericke, A Hernandez-Santana, A Lochter, A Shioi, A Yavorskyy, AJ Evans, AL Boskey, AM Simao, AS Haka, BK Seo, BL Eckhardt, C Maniatopoulos, C Peacock, CJ Aslakson, CM Büsing, CM Giachelli, CM Giachelli, DGA Nelson, DR Chen, E Mansson, E Thurfjell, EA McSherry, ES Tomlinson, G McMahon, GK Hunter, GS Stein, H Murer, H Orimo, J Chen, J H Harmey, JB Lian, JJ James, JN VanHouten, KA Lomashvili, L Frappart, L Frappart, L Hughes, L Tabar, M Gulsun, M Keykhosravani, M Lelekakis, M P Morgan, MJ Coelho, MJ Radi, MM Cooke, MP Morgan, PH Rolland, R Baker, R F Cox, R Robison, RC Shroff, S Hofvind, S Ramdass, SS Virk, T Kirsch, T Standal, TA Owen, TC Holme, W Jahnen-Dechent, WN Addison, X Wang   +62 more
core   +2 more sources

RNA sequencing of cancer reveals novel splicing alterations [PDF]

, 2013
Breast cancer transcriptome acquires a myriad of regulation changes, and splicing is critical for the cell to “tailor-make” specific functional transcripts.
Cyanam, Dinesh, Eswaran, Jeyanthy, Florea, Liliana D., Fuqua, Suzanne A. W., Godbole, Sucheta, Horvath, Anelia, Kumar, Rakesh, Mudvari, Prakriti, Nair, Sujit, Ohshiro, Kazufumi, Polyak, Kornelia, Reddy, Sirigiri Divijendra   +11 more
core   +2 more sources

Expression, regulation and clinical relevance of the ATPase Inhibitory Factor 1 (IF1) in human cancers [PDF]

, 2013
Recent findings in colon cancer cells indicate that inhibition of the mitochondrial H(+)-adenosine triphosphate (ATP) synthase by the ATPase inhibitory factor 1 (IF1) promotes aerobic glycolysis and a reactive oxygen species (ROS)-mediated signal that ...
Aldea, Marcos, Clofent, Juan, Cuezva, José M., Espinosa, Enrique, Formentini, Laura, García Bermúdez, Javier, Juarranz, Ángeles, López, Estela C., Martínez Reyes, Inmaculada, Navarro, Carmen, Nájera, Laura, Santacatterina, Fulvio, Sánchez Aragó, María, Sánchez Cenizo, Laura, Willers, Imke M.   +14 more
core   +2 more sources

Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer [PDF]

, 2012
INTRODUCTION: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is diagnosed in approximately 15% of all human breast cancer (BrCa) patients.
Aprelikova, Olga, Bennett, Christina N, Caplen, Natasha J, Chu, Isabel M, Green, Jeffrey E, Hollingshead, Melinda G, Luger, Dror, Michalowski, Aleksandra M, Mittereder, Lara R, Piwinica-Worms, Helen, Shou, James, Tomlinson, Christine C   +11 more
core   +2 more sources

Functional heterogeneity within the CD44 high human breast cancer stem cell-like compartment reveals a gene signature predictive of distant metastasis [PDF]

, 2006
The CD44(hi) compartment in human breast cancer is enriched in tumor-initiating cells; however, the functional heterogeneity within this subpopulation remains poorly defined.
D. Brand, D. D’Souza, E. Asarin, F. Laroussinie, J. Ouaknine, J. Ouaknine, J. Ouaknine, J. Ouaknine, L. Alfaro de, M. Faella, M. Faella, P. Bouyer, P. Bouyer, P.A. Abdulla, P.A. Abdulla, P.A. Abdulla, R. Alur, R. Alur, R. Alur, R. Koymans, S. Lasota, T..A. Henzinger   +21 more
core   +2 more sources

Preliminary characterization of IL32 in basal-like/triple negative compared to other types of breast cell lines and tissues [PDF]

, 2014
BACKGROUND: Triple negative breast cancer (TNBC) and often basal-like cancers are defined as negative for estrogen receptor, progesterone receptor and Her2 gene expression.
Audrey Player, Jennifer Okanmelu, Kayla Burrell, Mario Hollomon, Tim Oguamanam   +4 more
core   +2 more sources

Identification of chemotherapy resistance drivers in breast cancer cells [PDF]

, 2021
Breast cancer is a heterogenous disease with some subtypes posing a significant treatment challenge due to lack of targeted therapies and chemoresistance, particularly triple-negative metaplastic breast carcinoma (MBC).
Kumar, Uttom
core   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +3 more sources