Results 51 to 60 of about 282,442 (237)

Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery

Advanced Science, EarlyView.
Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou, Xin‐Ge Wang, Xuan‐Ren Shi, Shu‐Ting Sun, Jing Mi, Xiao‐Peng Zhang, Bin‐Cheng Yin, Ying Zhou, Bang‐Ce Ye   +8 more
wiley   +1 more source

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source

Knowledge and factors affecting initiation of breast feeding in post-natal mothers in a tertiary care center [PDF]

, 2018
Background: The study was planned to evaluate awareness of breast feeding among mother, institutional quality indicators of early breast feeding. The objective was to know factors causing delay in breast feeding initiation, to assess knowledge, cultural ...
Gavhane, Sunil, Jadhao, Pranoti, Kale, Anjali, Sirohi, Aniket, Uday, Kanumala, Yadav, Pawan, Yadav, Sudha   +6 more
core   +2 more sources

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

Advanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du, Jun Huang, Aizhen Zhang, Fangfang Zhao, Tianwen Chen, Quinn M. McDermott, Tony Zheng, Haibo Wang, Rongli Zhang, Xiaolin Zhang, Jerome Allison, Hong Zhu, Wu Zhou, Qing Yin Zheng   +13 more
wiley   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

Breast-feeding in Geneva: Prevalence, duration and determinants [PDF]

, 2018
Summary: A telephone survey was carried out with the objective of measuring the prevalence, duration and determinants of breast-feeding in the canton of Geneva, between August and December 1993.
Bouvier, Paul, Rougemont, André
core  

Awareness regarding breast feeding and complementary feeding in mothers of children with severe acute malnutrition at stabilization centre Multan [PDF]

, 2015
Breast feeding is the most natural way of feeding the infants and help to reduce child mortality and morbidity and millions of deaths could be prevented each year if mothers were aware of benefits of exclusive breast feeding for 4 -6 months and early ...
Arshad, Reema, Iqbal, Imran, Khan, Saadia   +2 more
core   +2 more sources

Breast-feeding - The view of women who breast-feed

Jornal de Pediatria, 1995
This is a qualitative study, the result of questions about breast-feeding in terms of the meaning it has for the woman who experiences it. The phenomenological theoretical background led to understand breast-feeding based on the dimension of a being who breast-feeds. Thus, we sought the discourse of women using the following guiding question: "What did
openaire   +3 more sources

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Perilaku Pemberian Asi terhadap Frekuensi Diare pada Anak Usia 6-24 Bulan di Ruang Anak Rumah Sakit Baptis Kediri [PDF]

, 2011
Backgorund : Breast feeding or ASI in Indonesia a magical and uncomparable liquid. This main nutrition is needed by newly born baby. The problem accurs when a mother decides to stop breast feeding to the newly born baby due to some reasons.
Febrijanto, Y. (Yoyok), Romoekoij, S. P. (Stefanny), Victoria, F. S. (Fitri)   +2 more
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