Results 121 to 130 of about 1,907,433 (308)

The histopathological results of 160 breast lesions.

, 2019
The histopathological results of 160 breast lesions.
Leidan Huang (2813917), Zheng Liu (28397), Mengke Ma (6997286), Zhen Du (782782), Xuehao Gong (2813920)   +4 more
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source

Positive Predictive Value of Breast Ultrasonography BI-RADS Category 4 and 5 Lesions in One Institution

, 2014
Purpose: To retrospectively analyze the positive predictive values (PPVs) of the breast lesions classified as categories 4 and 5 by using Breast Imaging reporting and Date System (BI-RADS) ultrasonography (US). Materials and Methods: Between May 2012 and
윤정현, 문희정, 양고은, 김은경, 김민정   +4 more
core  

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Positive Predictive Value of Breast Ultrasonography BI-RADS Category 4 and 5 Lesions in One Institution

, 2015
Purpose: To retrospectively analyze the positive predictive values (PPVs) of the breast lesions classified as categories 4 and 5 by using Breast Imaging reporting and Date System (BI-RADS) ultrasonography (US).
윤정현, 문희정, 김은경, 김민정, 채인혜   +4 more
core  

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Simulation of heterogeneity within breast lesions based upon Perlin noise

Steadily increasing use of computer-generated models sets high demands on the realistic representation of breast tissue and abnormalities. Previously, we demonstrated the use of Perlin noise to simulate breast lesions.
C. Vieira, Marcelo A.,, Zackrisson, Sophia,, Bakic, Predrag,, C. Costa, Arthur,, Tingberg, Anders,, Tomic, Hanna,, Lund University., Dustler, Magnus,, Dustler, Magnus, C. Vieira, Marcelo A., C. Costa, Arthur, Tingberg, Anders, Bakic, Predrag, Tomic, Hanna, Zackrisson, Sophia   +14 more
core   +1 more source

Imaging progress on reducing underestimation rate of papillary lesions of the breast

肿瘤影像学, 2017
Papillary lesions of the breast are a heterogeneous group of neoplasm. The lesions are always accompanied and affect the overall assessment of breast lesions. Particularly, new classifications of papillary lesions such as encapsulated papillary carcinoma
WANG Zekun
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