Results 201 to 210 of about 1,896,405 (407)

Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy

Advanced Science, EarlyView.
Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang, Shu‐Ying Li, Fang‐Fei Li, Qin‐Yan Shi, Cheng‐Yong Tan, Xiao‐Jing Wang, Mi Li, Yun‐Bao Liu, Jing Jin, Yong Li, Shi‐Shan Yu   +10 more
wiley   +1 more source

MicroRNA‐433‐3p enhances chemosensitivity of glioma to cisplatin by downregulating NR5A2

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
miR‐433‐3p mediated the ability of NR5A2 to regulate the malignant behavior of glioma cells Abstract Objective We attempted to investigate influence of microRNA‐433‐3p on malignant progression of glioma and identify its molecular mechanism, thus laying groundwork for glioma management.
Jun Li, Jingshun Gu, Juntong Wang, Aiwu You, Yuyan Zhang, Guomin Rao, Shuang Li, Xuehua Ge, Kun Zhang, Dongchun Wang   +9 more
wiley   +1 more source

Frequencies of activated T cell populations increase in breast milk of HCMV-seropositive mothers during local HCMV reactivation

Frontiers in Immunology
BackgroundHuman cytomegalovirus (HCMV) can reactivate in the mammary gland during lactation and is shed into breast milk of nearly every HCMV-IgG-seropositive mother of a preterm infant.
Katrin Lazar, Graham Pawelec, Graham Pawelec, Rangmar Goelz, Klaus Hamprecht, Kilian Wistuba-Hamprecht, Kilian Wistuba-Hamprecht, Kilian Wistuba-Hamprecht   +7 more
doaj   +1 more source

Cimetidine excretion into breast milk. [PDF]

, 1979
Andrew A. Somogyi, R Gugler
openalex   +1 more source

UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling

Advanced Science, EarlyView.
Lactylation of UDP‐glucose dehydrogenase (UGDH) represses its enzymatic activity and causes glycosaminoglycans loss. In addition, UGDH lactylation facilitates its interaction with chromosome region maintenance 1 (CRM1) and promotes the nucleocytoplasmic transport.
Weiren Lan, Xueman Chen, Huai Yu, Jianzhao Ruan, Jingliang Kang, Xiaoyu Nie, Yumei Cao, Su'an Tang, Changhai Ding   +8 more
wiley   +1 more source

Breast density in MRI: an AI-based quantification and relationship to assessment in mammography [PDF]

arXiv
Mammographic breast density is a well-established risk factor for breast cancer. Recently there has been interest in breast MRI as an adjunct to mammography, as this modality provides an orthogonal and highly quantitative assessment of breast tissue.
arxiv  

Breast Milk Jaundice: Effect of 3 20 -pregnanediol on Bilirubin Conjugation by Human Liver [PDF]

, 1970
B.P.F. Adlard, G. H. Lathe
openalex   +1 more source

Number of Breast Milk Bacteria in Women with Normal Labor and Caesarean Delivery During Room Temperature Storage [PDF]

The presence of microbes in each breast milk sample can be different, one of which is influenced by the method of delivery. The research aimed to analyze the effect of storage time for breast milk from mothers giving birth normally and giving birth by ...
Habibah, Siti Noor, Insana, Aima, Lutpiatina, Leka, Muhlisin, Ahmad   +3 more
core   +2 more sources

BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING

Advanced Science, EarlyView.
Based on IP‐MS analysis, BAG2 is confirmed to be essential for ubiquitination and protein homeostasis regulation of STING in cervical cancer. BAG2 inhibits the ubiquitination and degradation of STING by forming a complex with STUB1, thereby activating the type I IFN signaling pathway and inhibiting the development of cervical cancer.
Shijie Yao, Siming Chen, Anjin Wang, Ziyan Liang, Xuelian Liu, Yang Gao, Hongbing Cai   +6 more
wiley   +1 more source

Loss of energy during continuous infusions of breast milk. [PDF]

, 1978
O G Brooke, J. Barley
openalex   +1 more source