Results 1 to 10 of about 18,561 (232)

Human Milk Oligosaccharides as Promising Antivirals

Molecular Nutrition & Food Research, 2018
AbstractHuman milk oligosaccharides (HMOs) are diverse unconjugated carbohydrates that are highly abundant in human breast milk. These glycans are investigated in the context of exhibiting multiple functions in infant growth and development. They seem to provide protection against infectious diseases, including a number of poorly manageable viral ...
Morozov, V, Hansman, G, Hanisch, FG, Schroten, H, Kunz, C   +4 more
openaire   +4 more sources

Seal milk oligosaccharides rival human milk complexity and exhibit functional dynamics during lactation [PDF]

Nature Communications
Milk oligosaccharides are crucial for neonatal development and health in mammals. Yet most milk research focuses on humans, or on domesticated mammals that are poor in milk oligosaccharide complexity.
Chunsheng Jin, Jon Lundstrøm, Carmen R. Cori, Shih-Yun Guu, Alexander R. Bennett, Mirjam Dannborg, Patrick P. Pomeroy, Malcolm W. Kennedy, Johan Bengtsson-Palme, Rachel Hevey, Kay-Hooi Khoo, Daniel Bojar   +11 more
doaj   +2 more sources

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Exposure of Bifidobacterium longum subsp. infantis to Milk Oligosaccharides Increases Adhesion to Epithelial Cells and Induces a Substantial Transcriptional Response. [PDF]

PLoS ONE, 2013
In this study, we tested the hypothesis that milk oligosaccharides may contribute not only to selective growth of bifidobacteria, but also to their specific adhesive ability.
Devon W Kavanaugh, John O'Callaghan, Ludovica F Buttó, Helen Slattery, Jonathan Lane, Marguerite Clyne, Marian Kane, Lokesh Joshi, Rita M Hickey   +8 more
doaj   +1 more source

Fermented Citrus as a Functional Food Matrix: Evaluating Probiotic, Prebiotic, and Postbiotic Potential

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Fermented citrus transforms bioactive compounds into metabolites with probiotic and prebiotic properties, enhancing gut health, immunity, and metabolic balance. This review highlights fermentation's role in developing sustainable, health‐promoting functional foods while addressing challenges in process optimization, sensory quality, and commercial ...
Sony Kumari, Rahel Debbarma, Shakil Haque, Himalay Baruah   +3 more
wiley   +1 more source

Citrus aurantium honey‐mediated gut homeostasis and anti‐inflammation via Thorl/Nprl2‐TORC1 signaling: Network pharmacology and Drosophila validation

Animal Models and Experimental Medicine, EarlyView.
The study employed a four‐tiered strategy: (1) UHPLC‐FTMS profiling of Citrus aurantium honey to characterize its chemical composition; (2) network pharmacology analysis integrating target prediction, protein–protein interaction networks, and KEGG pathway enrichment to identify the Thor1/Nprl2‐TORC1 axis as a key mechanistic pathway; (3) in vitro ...
Wenqi Wan, Ruiguang Huang, Shuqiong Cao, Luxia Pan, Wenkai Zhang, Wujun Jiang, Zhiyong Liu   +6 more
wiley   +1 more source

Advances in Analysis of Human Milk Oligosaccharides [PDF]

Advances in Nutrition, 2012
Oligosaccharides in human milk strongly influence the composition of the gut microflora of neonates. Because it is now clear that the microflora play important roles in the development of the infant immune system, human milk oligosaccharides (HMO) are studied frequently.
L Renee, Ruhaak, Carlito B, Lebrilla
openaire   +2 more sources

Unusual free trisaccharides in caprine colostrum discovered by logically derived sequence tandem mass spectrometry

Scientific Reports
Free oligosaccharides in human milk have many biological functions for infant health. The reducing end of most human milk oligosaccharides is lactose, and caprine milk was reported to contain oligosaccharides structurally similar to those present in ...
Wei-Chien Weng, Hung-En Liao, Cheng-Hsiu Chang, Shang-Cheng Hung, Kai Du, Zhijay Tu, Chun-Hung Lin, Chi-Kung Ni   +7 more
doaj   +1 more source

Tailoring Human Milk Oligosaccharides to Prevent Necrotising Enterocolitis Among Preterm Infants

Frontiers in Nutrition, 2021
Necrotising enterocolitis (NEC) is a devastating disease affecting preterm infants, with little improvement in mortality rates and treatment strategies in the last 30 years.
Safiyyah Abbas, Amy K. Keir, Amy K. Keir, Amy K. Keir, Amy K. Keir, Maria Makrides, Maria Makrides, Laura D. Klein, Luke E. Grzeskowiak, Luke E. Grzeskowiak, Andrew J. McPhee, Alice R. Rumbold, Alice R. Rumbold, Alice R. Rumbold   +13 more
doaj   +1 more source