Results 91 to 100 of about 1,964,079 (337)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
, 2023 Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive hematologic malignancy that arises from plasmacytoid dendritic cells.
Beth M. Siegel +4 more
core +1 more source
Primary osteogenic sarcoma of the breast
World Journal of Surgical Oncology, 2006 Background Primary extra-osseous osteogenic sarcomas have been reported in many tissues of the body but their occurrence in the breast is extremely rare. It can arise as a result of osseous metaplasia in a pre-existing benign or malignant neoplasm of the
Akang Effiong E +4 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Revista Eniac Pesquisa, 2018 Breast cancer is the leading cause of death due to neoplasm in the female gender. Adjuvant hormone therapy is an important ally in breast cancer treatment because it improves survival and decreases the recurrence of neoplasm.
Fabiana Mesquita Roese +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Breast cancer pathology, types of neoplasia and number of cases in a General Surgery Department
Applied Medical Informatics, 2019 Introduction: Quality of Life (QOL) is a complex concept considered a construct with many different facets which has a strong impact in the socio-medical field.
Mirela VȂLCAN +2 more
doaj
Occult Breast Cancer due to Multiple Calcified Hamartomas in a Patient with Cowden Syndrome
Case Reports in Radiology, 2012 Cowden syndrome (CS) is an autosomal dominant disorder characterized by presence of multiple hamartomas, and other benign and malignant abnormalities of the breasts, skin, thyroid, endometrium, gastrointestinal tract, and central nervous system ...
E. B. Gómez García +7 more
doaj +1 more source
Carcinosarcoma of breast – A chimera among breast neoplasms
Journal of Family Medicine and Primary CareABSTRACT Malignant phyllodes, along with ductal carcinoma, is known as metaplastic cancer of the breast. This tumor is additionally known as breast carcinosarcoma. Malignant phyllodes in conjunction with ductal carcinoma is a rare finding in routine clinical practice.
Vandana Tomey +3 more
openaire +3 more sources