Results 101 to 110 of about 1,964,079 (337)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

A massive malignant phyllodes tumor – case study

Current Issues in Pharmacy and Medical Sciences, 2021
The paper aims to introduce the case of an extensive breast malignancy – phyllodes tumor. This type of breast neoplasm is relatively rare. Indeed, it accounts for only 0.3-1% of all breast malignant tumours.
Madej-Czerwonka Barbara
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Children, family and cancer survival in Norway [PDF]

Models for all-cause mortality among 45000 men and women with cancer in 12 different sites were estimated, using register and census data for complete Norwegian birth cohorts. This observed-survival method seemed to be an adequate approach.
Kravdal, Øystein
core  

Secondary breast angiosarcoma: A multicentre retrospective survey by the national Italian association of Breast Surgeons (ANISC) [PDF]

, 2019
Background: Breast angiosarcoma is a malignant mesenchymal neoplasm, which accounts for approximately 2% of all soft tissue sarcomas. Secondary breast angiosarcoma (SBA) may be related to chronic lymphedema after a mastectomy with lymph node dissection ...
Cabula C., Pollini G., Orzalesi, L, Friedman, D, Mariotti C., Rovera, F, Grassi M., Rovera F., Cedolini, C, Meattini I., Tinterri C., Caruso F., Pollini, G, Caruso, F, Terribile, D, Cabula, C, Pellegrini A., Bortul, M, Taffurelli, M, Cianchetti, E, Roncella, M, Galimberti V., Cianchetti E., Procaccini E., Orzalesi, L., Pellegrini, A, Cappella, A, Friedman D., Meattini, I., Thomas R., Lucani, G, Grassi, M, Orzalesi L., Scarabeo, F, Tinterri, C, Stacul, G, Mariotti, C, Lucani G., Scarabeo F., Tazzioli, G, Roncella M., Stacul G., Taffurelli M., Procaccini, E, Meattini, I, Terribile D., Cappella A., Tazzioli G., Thomas, R, Cedolini C., Bortul M., Galimberti, V   +51 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Dermatofibrosarcoma presenting as a nodule in the breast of a 75-year-old woman: a case report

Journal of Medical Case Reports, 2011
Introduction Dermatofibrosarcoma protuberans is a rare neoplasm of soft tissues and its location in the breast is extremely uncommon. Confusion is possible with other primary breast lesions.
Delaloye¹ Jean-François, Meuwly Jean-Yves, Fiche Maryse, Cottier Olivier   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A Systematic Review: Examining the Relationship Between Coffee Consumption and Breast Cancer

, 2013
BACKGROUND: Breast cancer is the most common type of on cancer in women in both developed and developing countries. Breast cancer is the number one cause of death in women globally. Coffee is the world’s leading consumed beverage after water.
Pillay, Lalini
core   +1 more source