Results 81 to 90 of about 245,977 (262)

Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea

open access: yesAdvanced Science, EarlyView.
This study indicates that Serpine2 plays a pivotal role in hair cell (HC) regeneration from Lgr5+ progenitors in the neonatal mouse cochlea. Conditional overexpression of Serpine2 in cochlear Lgr5+ progenitors results in a significantly increased number of ectopic HCs, particularly ectopic inner HCs, and these HCs are likely derived from Lgr5 ...
Hairong Xiao   +14 more
wiley   +1 more source

Cryo‐EM Analysis of a Tri‐Heme Cytochrome‐Associated RC‐LH1 Complex from the Marine Photoheterotrophic Bacterium Dinoroseobacter Shibae

open access: yesAdvanced Science, EarlyView.
Cryo‐EM reveals a closed 17‐subunit LH ring encircling the RC‐LH1 complex in Dinoroseobacter shibae, featuring a novel helix‐turn‐helix subunit bridging RC and LH. Mg2⁺/Ca2⁺ stabilizes the complex, while periplasmic Cyt c₂ mediates electron transfer via a tri‐heme Cyt to the special pair of bacteriochlorophylls. Insights into energy/electron efficiency
Weiwei Wang   +12 more
wiley   +1 more source

Deep Learning-based Initialization of Iterative Reconstruction for Breast Tomosynthesis [PDF]

open access: yesProc. CT Meeting (2020) 438-441, 2020
Reconstruction of digital breast tomosynthesis is a challenging problem due to the limited angle data available in such systems. Due to memory limitations, deep learning-based methods can help improve these reconstructions, but can not (yet) attain sufficiently high resolution. In addition to this practical issue, questions remain on the possibility of
arxiv  

Immediate Breast Reconstruction with Free Autologous Tissue Transfer [PDF]

open access: yes, 2019
Immediate breast reconstruction in the United States is increasing with the majority of patients undergoing implant-based reconstruction. The use of pedicled autologous tissues has also been used, but due to significant donor site morbidity, free ...
Inchauste, Suzanne   +2 more
core   +1 more source

Exploring the Latent Information in Spatial Transcriptomics Data via Multi‐View Graph Convolutional Network Based on Implicit Contrastive Learning

open access: yesAdvanced Science, EarlyView.
STMIGCL is an implicit contrastive learning‐based multi‐view graph convolutional network framework designed for downstream tasks such as spatial domain recognition, trajectory inference, and spatially variable gene identification. By combining multi‐view learning with contrastive learning and employing contrastive learning methods that enhance contrast
Sheng Ren   +5 more
wiley   +1 more source

Comparison of reconstruction algorithms for digital breast tomosynthesis [PDF]

open access: yesarXiv, 2009
Digital breast tomosynthesis (DBT) is an emerging modality for breast imaging. A typical tomosynthesis image is reconstructed from projection data acquired at a limited number of views over a limited angular range. In general, the quantitative accuracy of the image can be significantly compromised by severe artifacts and non-isotropic resolution ...
arxiv  

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

open access: yesAdvanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han   +10 more
wiley   +1 more source

Integration of patient-reported outcome measures with key clinical outcomes after immediate latissimus dorsi breast reconstruction and adjuvant treatment

open access: yes, 2013
Background: linical evidence on patient-reported outcome measures (PROMS) in breast reconstruction is lacking. The aim of this study was to evaluate PROMs in implant-assisted latissimus dorsi (LDI) or tissue-only autologous latissimus dorsi (ALD) flap ...
Balta, V   +6 more
core   +1 more source

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

open access: yesAdvanced Science, EarlyView.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang   +8 more
wiley   +1 more source

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