Results 71 to 80 of about 680,154 (292)

Genetic regulation of sperm DNA methylation in cattle through meQTL mapping

BMC Genomics
Background DNA methylation (DNAm) plays an important functional role and is influenced by genetic variants known as methylation QTLs (meQTLs). The majority of meQTL studies have been conducted in human blood.
Corentin Fouéré, Valentin Costes, Chris Hozé, Amrita Raja Ravi Shankar, Florian Besnard, Gabriel Costa Monteiro Moreira, Valentin Sorin, Chrystelle Le Danvic, Aurélie Chaulot-Talmon, Francesca Ali, Marie Christine Deloche, Aurélie Bonnet, Eliaou Sellem, Hélène Jammes, Sébastien Fritz, Mekki Boussaha, Didier Boichard, Hélène Kiefer, Marie-Pierre Sanchez   +18 more
doaj   +1 more source

Necrotizing meningoencephalitis in atypical dog breeds: a case series and literature review. [PDF]

, 2014
BackgroundCanine necrotizing meningoencephalitis (NME) is a fatal, noninfectious inflammatory disease of unknown etiology. NME has been reported only in a small number of dog breeds, which has led to the presumption that it is a breed-restricted disorder.
Cooper, JJ, Levine, JM, Porter, BF, Schatzberg, SJ, Siso, S, Summers, BA, Vernau, KM, Young, BD   +7 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Nationwide genetic testing towards eliminating Lafora disease from Miniature Wirehaired Dachshunds in the United Kingdom

Canine Genetics and Epidemiology, 2018
Background Canine DNA-testing has become an important tool in purebred dog breeding and many breeders use genetic testing results when planning their breeding strategies.
Saija Ahonen, Ian Seath, Clare Rusbridge, Susan Holt, Gill Key, Travis Wang, Peixiang Wang, Berge A. Minassian   +7 more
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

The Art (and Science) of Breeding Fish in Captivity [PDF]

, 2012
To reduce the impact of harvesting fish from natural habitats, RWU experts to teach aquarists to breed fish for exhibit ...
Mulvey, Jenna
core   +1 more source

Breeding without Breeding: Is a Complete Pedigree Necessary for Efficient Breeding?

PLoS ONE, 2011
Complete pedigree information is a prerequisite for modern breeding and the ranking of parents and offspring for selection and deployment decisions. DNA fingerprinting and pedigree reconstruction can substitute for artificial matings, by allowing parentage delineation of naturally produced offspring.
Yousry A El-Kassaby, Eduardo P Cappa, Cherdsak Liewlaksaneeyanawin, Jaroslav Klápště, Milan Lstibůrek   +4 more
openaire   +4 more sources

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

American Myth-Busting [PDF]

, 2012
In this essay, Joe Wilkins discusses the new breed of western ...
Wilkins, Joe
core   +1 more source

Whole genome sequencing for mutation discovery in a single case of lysosomal storage disease (MPS type 1) in the dog. [PDF]

, 2020
Mucopolysaccharidosis (MPS) is a metabolic storage disorder caused by the deficiency of any lysosomal enzyme required for the breakdown of glycosaminoglycans.
Aguilar, Miriam, Ancona, Devin, Bannasch, Danika, Brown, C. Titus, Cowan, Tina, Knipe, Marguerite, Mansour, Tamer, Moore, Bret, Seada, Haitham, Sebbag, Lionel, Sebbag, Lionel, Thomasy, Sara, Vernau, Karen, Woolard, Kevin   +13 more
core   +3 more sources